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Study · Randomized controlled trial · n = 137 · 2025

4 results

Oxytocin moderates fMRI connectivity and response to implicit threat processing in cocaine use disorder.

Blidy KP, Bustos N, Spalten J, Crum KI, Jarnecke AM, Flanagan JC, Baker NL, Moran Santa-Maria M, Hartwell KJ, Brady KT, McRae-Clark AL, Joseph JE

Psychoneuroendocrinology10 Oct 2024Cited by 2 (Europe PMC)

PMID39413528 (opens in a new tab)PMCIDPMC11568897 (opens in a new tab)DOI10.1016/j.psyneuen.2024.107217 (opens in a new tab)PepBankPUB-39413528
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with and without cocaine use disorder, intranasal oxytocin 24 IU reduced thalamus and pontine reticular formation activation to fear cues versus placebo.

    In plain wordsIn adults with and without cocaine use disorder, oxytocin lowered brain activity in two regions in response to fear faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseThalamus and pontine reticular formation activation to fear cues
    Study

    n = 137

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    OXT reduced activation in the thalamus and pontine reticular formation in response to fear cues, and in the supplementary motor area for both fear and anger cues, regardless of CUD status.
    1 context sentence
    Summary · context
    To address this gap, the present study administered intranasal OXT (24 IU) or placebo (PBO) to participants with CUD (CUD+, N = 76) or without CUD (CUD-, N = 61) in a randomized parallel design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with and without cocaine use disorder, intranasal oxytocin 24 IU reduced supplementary motor area activation to fear and anger cues versus placebo.

    In plain wordsIn adults with and without cocaine use disorder, oxytocin lowered activity in a movement-planning brain area when people saw threat faces, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseSupplementary motor area activation to fear and anger cues
    Study

    n = 137

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    OXT reduced activation in the thalamus and pontine reticular formation in response to fear cues, and in the supplementary motor area for both fear and anger cues, regardless of CUD status.
    1 context sentence
    Summary · context
    To address this gap, the present study administered intranasal OXT (24 IU) or placebo (PBO) to participants with CUD (CUD+, N = 76) or without CUD (CUD-, N = 61) in a randomized parallel design.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with cocaine use disorder, intranasal oxytocin reversed the negative amygdala-medial prefrontal connectivity to fear cues seen under placebo to positive coupling.

    In plain wordsIn adults with cocaine use disorder, oxytocin changed a negative link between two brain regions into a positive link, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAmygdala-medial prefrontal cortex connectivity to fear cues in CUD+
    Study

    n = 76

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Additionally, under PBO, amygdala-medial prefrontal cortex connectivity to fear stimuli was negative for the CUD+ group, but under OXT, this coupling was positive, similar to the positive coupling observed for the CUD- group under both PBO and OXT administration.
    2 context sentences
    Summary · context
    The finding of OXT-mediated reversal of amygdala-prefrontal coupling was specific to CUD+ and suggests that OXT alters circuitry related to threat surveillance and implicit emotion regulation in CUD.
    Summary · context
    To address this gap, the present study administered intranasal OXT (24 IU) or placebo (PBO) to participants with CUD (CUD+, N = 76) or without CUD (CUD-, N = 61) in a randomized parallel design.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In adults without cocaine use disorder, amygdala-medial prefrontal connectivity to fear cues was positive under both placebo and oxytocin.

    In plain wordsIn adults without cocaine use disorder, the brain link stayed positive with both oxytocin and placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmygdala-medial prefrontal cortex connectivity to fear cues in CUD-
    Study

    n = 61

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    similar to the positive coupling observed for the CUD- group under both PBO and OXT administration
    1 context sentence
    Summary · context
    To address this gap, the present study administered intranasal OXT (24 IU) or placebo (PBO) to participants with CUD (CUD+, N = 76) or without CUD (CUD-, N = 61) in a randomized parallel design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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