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Study · In vitro (cells) · rat · 2024

3 results

The Effects of IGF1 and MGF on Neural Stem Cells in Hypoxic Conditions.

Aydıntuğ-Gürbüz T, Toprak F, Toprak S, Sözer S

Basic and clinical neuroscience1 May 2024

PMID39403354 (opens in a new tab)PMCIDPMC11470890 (opens in a new tab)DOI10.32598/bcn.2022.3981.1 (opens in a new tab)PepBankPUB-39403354
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat hippocampal neural stem cells in anoxia, applied MGF upregulated HIF-1α relative gene expression.

    In plain wordsIn rat brain stem cells without oxygen, added MGF raised HIF-1α gene activity.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseHIF-1α gene expression after MGF application
    Study

    ratn: not reported in source

    Rat hippocampal neural stem cells under 0%, 3% and 20% oxygen for 24 h
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    whereas MGF application upregulated its change in an anoxic environment
    1 context sentence
    Summary · context
    An in vitro ischemia model was created by rat hippocampal NSC grown in culture that was exposed to varying oxygen levels, including 0%, 3%, and 20 % for the representation of anoxic, hypoxic, and normoxic conditions, respectively, during 24 h.
  2. 02LabIn vitro (cells)Efficacy outcome

    In rat hippocampal neural stem cells, MGF-induced cells had a higher proliferation-migration rate in all oxygen conditions.

    In plain wordsIn rat brain stem cells, added MGF increased cell growth and movement at all oxygen levels.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseNSC proliferation-migration rate with MGF
    Study

    ratn: not reported in source

    Rat hippocampal neural stem cells under 0%, 3% and 20% oxygen for 24 h
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, MGF-induced NSC had more proliferationmigration rate in all oxygen conditions.
    1 context sentence
    Summary · context
    An in vitro ischemia model was created by rat hippocampal NSC grown in culture that was exposed to varying oxygen levels, including 0%, 3%, and 20 % for the representation of anoxic, hypoxic, and normoxic conditions, respectively, during 24 h.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03LabEndogenous levelIn vitro (cells)Mechanism

    In rat hippocampal neural stem cells, MGF gene expression increased under low oxygen, with anoxia as the strongest stimulant.

    In plain wordsIn rat brain stem cells, the cells' own MGF gene activity rose under low oxygen, most under no oxygen.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF gene expression under low oxygen
    Study

    ratn: not reported in source

    Rat hippocampal neural stem cells under 0%, 3% and 20% oxygen for 24 h
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Increased IGF-I and MGF gene expressions were detected in the samples exposed to low O2. Anoxia was the highest stimulant for IGF-I and MGF gene expressions.
    1 context sentence
    Summary · context
    An in vitro ischemia model was created by rat hippocampal NSC grown in culture that was exposed to varying oxygen levels, including 0%, 3%, and 20 % for the representation of anoxic, hypoxic, and normoxic conditions, respectively, during 24 h.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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