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Study · Animal study (in vivo) · 2024

2 results

Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy.

Liu K, Kong L, Cui H, Zhang L, Xin Q, Zhuang Y, Guo C, Yao Y, Tao J, Gu X, Jiang C, Wu J

Cell reports. Medicine1 Oct 2024Cited by 59 (Europe PMC)

PMID39357524 (opens in a new tab)PMCIDPMC11513825 (opens in a new tab)DOI10.1016/j.xcrm.2024.101751 (opens in a new tab)PepBankPUB-39357524
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In tumors treated with type V adenovirus, thymosin alpha‑1 reprogrammed M2-like tumor-associated macrophages toward an antitumoral phenotype.

    In plain wordsIn tumor models treated with a virus therapy, thymosin alpha‑1 shifted tumor immune cells from a tumor-helping state to an anti-tumor state.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseM2-like tumor-associated macrophage phenotype
    Study

    n: not reported in source

    Comparator
    Oncolytic adenovirus alone
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By selectively compensating for these deficiencies, thymosin alpha 1 (Tα1) reprograms "M2-like" TAMs toward an antitumoral phenotype, thereby reprogramming the TME into a state more beneficial for antitumor immunity.
    1 context sentence
    Summary · context
    Here, we demonstrate that type V adenovirus (ADV) induces the polarization of tumor-associated macrophages (TAMs) to the M2 phenotype and increases the infiltration of regulatory T cells (Tregs) in the tumor microenvironment (TME).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    Both exogenously supplied and adenovirus-produced thymosin alpha‑1 enhanced the antitumor efficacy of the oncolytic adenovirus through CD8+ T cells.

    In plain wordsIn tumor models, thymosin alpha‑1 made the virus therapy work better against tumors, through CD8+ T cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAntitumor efficacy of oncolytic adenovirus
    Study

    n: not reported in source

    Comparator
    Oncolytic adenovirus alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both exogenously supplied and adenovirus-produced Tα1 orchestrate TAM reprogramming and enhance the antitumor efficacy of ADV via CD8+ T cells, showing promising prospects for clinical translation.
    1 context sentence
    Summary · context
    Here, we demonstrate that type V adenovirus (ADV) induces the polarization of tumor-associated macrophages (TAMs) to the M2 phenotype and increases the infiltration of regulatory T cells (Tregs) in the tumor microenvironment (TME).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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