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Study · Animal study (in vivo) · rat · 2024

6 results

Healing sequelae following tooth extraction and dental implant placement in an aged, ovariectomy model.

Latimer JM, Maekawa S, Shiba T, Fretwurst T, Chen M, Larsson L, Sugai JV, Kostenuik P, Mitlak B, Lanske B, Giannobile WV

JBMR plus31 Aug 2024Cited by 5 (Europe PMC)

PMID39347482 (opens in a new tab)PMCIDPMC11427826 (opens in a new tab)DOI10.1093/jbmrpl/ziae113 (opens in a new tab)PepBankPUB-39347482
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Summary

At present, a lack of consensus exists regarding the clinical impact of osteoporosis on alveolar bone metabolism during implant osseointegration. While limited preclinical and clinical evidence demonstrates a negative influence of osteoporosis on dental extraction socket healing, no preclinical studies offer data on the results of implant placement in 6-mo-old, ovariectomized (OVX) Sprague-Dawley rats. This study aimed to investigate the outcomes of dental tooth extraction socket healing and implant placement in a rodent model of osteoporosis following daily vehicle (VEH) or abaloparatide (ABL) administration. Micro-CT and histologic analysis demonstrated signs of delayed wound healing, consistent with alveolar osteitis in extraction sockets following 42 d of healing in both the VEH and ABL groups. In a semiquantitative histological analysis, the OVX-ABL group demonstrated a tendency for improved socket regeneration with a 3-fold greater rate for moderate socket healing when compared to the OVX-VEH group (43% vs 14%), however, this finding was not statistically significant (p=.11). No significant differences were observed between vehicle and test groups in terms of implant outcomes (BMD and bone volume/total volume) at 14- and 21-d post-implant placement. Abaloparatide (ABL) significantly increased BMD of the femoral shaft and intact maxillary alveolar bone sites in OVX animals, demonstrating the therapeutic potential for oral hard tissue regeneration. The present model involving estrogen-deficiency-induced bone loss demonstrated an impaired healing response to dental extraction and implant installation.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, moderate socket healing occurred in 43% with abaloparatide versus 14% with vehicle, without statistical significance.

    In plain wordsIn rats, moderate socket healing was numerically higher with abaloparatide than vehicle, but the difference was not statistically significant.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeModerate socket healing
    Study

    ratn: not reported in source

    ovariectomized Sprague-Dawley rats
    Comparator
    vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a semiquantitative histological analysis, the OVX-ABL group demonstrated a tendency for improved socket regeneration with a 3-fold greater rate for moderate socket healing when compared to the OVX-VEH group (43% vs 14%), however, this finding was not statistically significant (p=.11).
    1 context sentence
    Summary · context
    This study aimed to investigate the outcomes of dental tooth extraction socket healing and implant placement in a rodent model of osteoporosis following daily vehicle (VEH) or abaloparatide (ABL) administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, implant BMD did not differ significantly between abaloparatide and vehicle at 14 and 21 days.

    In plain wordsIn rats, implant bone density did not differ significantly between abaloparatide and vehicle.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeImplant BMD
    Study

    ratn: not reported in source

    ovariectomized Sprague-Dawley rats
    Comparator
    vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No significant differences were observed between vehicle and test groups in terms of implant outcomes (BMD and bone volume/total volume) at 14- and 21-d post-implant placement.
    1 context sentence
    Summary · context
    This study aimed to investigate the outcomes of dental tooth extraction socket healing and implant placement in a rodent model of osteoporosis following daily vehicle (VEH) or abaloparatide (ABL) administration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, implant bone volume/total volume did not differ significantly between abaloparatide and vehicle at 14 and 21 days.

    In plain wordsIn rats, implant bone volume fraction did not differ significantly between abaloparatide and vehicle.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeImplant bone volume fraction
    Study

    ratn: not reported in source

    ovariectomized Sprague-Dawley rats
    Comparator
    vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No significant differences were observed between vehicle and test groups in terms of implant outcomes (BMD and bone volume/total volume) at 14- and 21-d post-implant placement.
    1 context sentence
    Summary · context
    This study aimed to investigate the outcomes of dental tooth extraction socket healing and implant placement in a rodent model of osteoporosis following daily vehicle (VEH) or abaloparatide (ABL) administration.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, abaloparatide significantly increased femoral shaft BMD.

    In plain wordsIn rats with ovariectomy, abaloparatide increased femoral shaft bone density.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseFemoral shaft BMD
    Study

    ratn: not reported in source

    ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Abaloparatide (ABL) significantly increased BMD of the femoral shaft and intact maxillary alveolar bone sites in OVX animals, demonstrating the therapeutic potential for oral hard tissue regeneration.
    1 context sentence
    Summary · context
    This study aimed to investigate the outcomes of dental tooth extraction socket healing and implant placement in a rodent model of osteoporosis following daily vehicle (VEH) or abaloparatide (ABL) administration.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, abaloparatide significantly increased BMD at intact maxillary alveolar bone sites.

    In plain wordsIn rats with ovariectomy, abaloparatide increased bone density at intact upper-jaw alveolar sites.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseIntact maxillary alveolar BMD
    Study

    ratn: not reported in source

    ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Abaloparatide (ABL) significantly increased BMD of the femoral shaft and intact maxillary alveolar bone sites in OVX animals, demonstrating the therapeutic potential for oral hard tissue regeneration.
    1 context sentence
    Summary · context
    This study aimed to investigate the outcomes of dental tooth extraction socket healing and implant placement in a rodent model of osteoporosis following daily vehicle (VEH) or abaloparatide (ABL) administration.

Studies that did not test the peptide alone1

In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Abaloparatide (Tymlos).

  1. 06AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, delayed extraction socket healing consistent with alveolar osteitis occurred in both vehicle and abaloparatide groups after 42 days.

    In plain wordsIn rats, both vehicle and abaloparatide groups showed delayed socket healing after 42 days.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    Not applicableDelayed extraction socket healing
    Study

    ratn: not reported in source

    ovariectomized Sprague-Dawley rats
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Micro-CT and histologic analysis demonstrated signs of delayed wound healing, consistent with alveolar osteitis in extraction sockets following 42 d of healing in both the VEH and ABL groups.
    1 context sentence
    Summary · context
    This study aimed to investigate the outcomes of dental tooth extraction socket healing and implant placement in a rodent model of osteoporosis following daily vehicle (VEH) or abaloparatide (ABL) administration.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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