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Study · Measured the body's own peptide · 2024

3 results

Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner.

Zhang Y, Huang J, Li S, Jiang J, Sun J, Chen D, Pang Q, Wu Y

Journal of agricultural and food chemistry11 Sept 2024Cited by 15 (Europe PMC)

PMID39259217 (opens in a new tab)DOI10.1021/acs.jafc.4c03502 (opens in a new tab)PepBankPUB-39259217
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice with radiation-induced lung injury, pyrroloquinoline quinone (PQQ) upregulated the body's own MOTS‑c mRNA and protein levels in irradiated lung tissue.

    In plain wordsIn mice with radiation lung injury, the vitamin-like PQQ raised the body's own MOTS‑c levels in lung tissue.

    Peptide
    MOTS-c
    Outcome
    IncreaseMOTS-c mRNA and protein levels in irradiated lung tissue
    Study

    mousen: not reported in source

    Radiation-induced lung injury (20 Gy thoracic X-ray)
    Outcome group
    Mitochondrial function · Respiratory

    Source sentences

    Summary
    Mechanistically, PQQ upregulated the mRNA and protein levels of MOTS-c in irradiated lung tissue and MLE-12 cells.
    1 context sentence
    Summary · context
    C57BL/6 mice were exposed to a 20 Gy dose of X-ray radiation on the entire thorax with or without daily oral administration of PQQ for 2 weeks.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In MLE-12 cells, pyrroloquinoline quinone (PQQ) upregulated the cells' own MOTS‑c mRNA and protein levels.

    In plain wordsIn lab-grown lung cells, PQQ raised the cells' own MOTS‑c levels.

    Peptide
    MOTS-c
    Outcome
    IncreaseMOTS-c mRNA and protein levels in irradiated MLE-12 cells
    Study

    n: not reported in source

    MLE-12 cells
    Outcome group
    Mitochondrial function · Respiratory

    Source sentences

    Summary
    Mechanistically, PQQ upregulated the mRNA and protein levels of MOTS-c in irradiated lung tissue and MLE-12 cells.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MOTS-c.

  1. 03LabNot a test of MOTS-c aloneIn vitro (cells)Mechanism

    Knockdown of MOTS‑c by siRNA substantially attenuated the protective effects of PQQ on oxidative stress, inflammation and apoptosis.

    In plain wordsWhen the body's own MOTS‑c was switched off, the protective effects of PQQ were much weaker.

    Peptide
    MOTS-c
    Outcome
    DecreasePQQ protection after MOTS-c knockdown
    Study

    n: not reported in source

    MLE-12 cells
    Comparator
    Without MOTS-c knockdown
    Outcome group
    Receptor activity and mechanism · Respiratory

    Source sentences

    Summary
    Knockdown of MOTS-c by siRNA substantially attenuated the protective effects of PQQ on oxidative stress, inflammation, and apoptosis.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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