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Study · Randomized controlled trial · n = 70 · 2024

5 results

Oxytocin modulation of explicit pandemic stigma in men with varying social anxiety levels.

Wang Y, Zhu J, Wang J, Mu Y

Neuropharmacology7 Sept 2024

PMID39251086 (opens in a new tab)DOI10.1016/j.neuropharm.2024.110140 (opens in a new tab)PepBankPUB-39251086
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In men, intranasal oxytocin strengthened the connections between responsibility attribution and the emotional, approach motivation and social deviance processes of stigma compared with placebo.

    In plain wordsIn men, nasal oxytocin strengthened links between blaming and other parts of stigma compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseConnections between responsibility attribution and other stigma processes
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Furthermore, oxytocin strengthened the connections between responsibility attribution and the other processes (i.e., emotional, approach motivation, social deviance).
    2 context sentences
    Summary · context
    To address this gap, we performed a double-blind, placebo-controlled, within-subject design study with 70 males, to investigate the effect of intranasal oxytocin (OT) administration on the explicit and implicit processing of disease-related stigma (i.e., COVID-19 stigma).
    Summary · context
    After self-administrated 24 IU of OT or placebo, participants completed a stigma evaluation task and an Implicit Association Test (IAT) to assess the explicit and implicit processes of stigma evaluation, respectively.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In men, intranasal oxytocin did not modulate implicit disease-related stigma compared with placebo.

    In plain wordsIn men, nasal oxytocin did not change hidden, automatic stigma compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeImplicit stigma (Implicit Association Test)
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    While no modulation of oxytocin on implicit stigma emerged, oxytocin did modulate the associations between specific dimensions of explicit stigma (i.e., social deviance and approach motivation) and implicit stigma.
    2 context sentences
    Summary · context
    To address this gap, we performed a double-blind, placebo-controlled, within-subject design study with 70 males, to investigate the effect of intranasal oxytocin (OT) administration on the explicit and implicit processing of disease-related stigma (i.e., COVID-19 stigma).
    Summary · context
    After self-administrated 24 IU of OT or placebo, participants completed a stigma evaluation task and an Implicit Association Test (IAT) to assess the explicit and implicit processes of stigma evaluation, respectively.
  3. 03HumanRandomized controlled trialMechanism

    In men, intranasal oxytocin modulated the associations between specific explicit stigma dimensions (social deviance and approach motivation) and implicit stigma compared with placebo.

    In plain wordsIn men, nasal oxytocin changed how some open stigma views were linked to automatic stigma compared with placebo.

    Peptide
    Oxytocin
    Outcome
    MixedAssociations between explicit and implicit stigma dimensions
    Study

    n = 70

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    oxytocin did modulate the associations between specific dimensions of explicit stigma (i.e., social deviance and approach motivation) and implicit stigma.
    2 context sentences
    Summary · context
    To address this gap, we performed a double-blind, placebo-controlled, within-subject design study with 70 males, to investigate the effect of intranasal oxytocin (OT) administration on the explicit and implicit processing of disease-related stigma (i.e., COVID-19 stigma).
    Summary · context
    After self-administrated 24 IU of OT or placebo, participants completed a stigma evaluation task and an Implicit Association Test (IAT) to assess the explicit and implicit processes of stigma evaluation, respectively.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In men with high social anxiety, intranasal oxytocin increased the attribution of stigmatized status to personal causes compared with placebo.

    In plain wordsIn men with high social anxiety, nasal oxytocin raised blaming of stigmatized people for their situation compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseExplicit COVID-19 stigma, attribution to personal causes in high social anxiety
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    with a higher inclination to attribute the stigmatized status of the stigmatized targets (i.e., COVID-19 related group) to personal causes in high social anxiety individuals
    2 context sentences
    Summary · context
    To address this gap, we performed a double-blind, placebo-controlled, within-subject design study with 70 males, to investigate the effect of intranasal oxytocin (OT) administration on the explicit and implicit processing of disease-related stigma (i.e., COVID-19 stigma).
    Summary · context
    After self-administrated 24 IU of OT or placebo, participants completed a stigma evaluation task and an Implicit Association Test (IAT) to assess the explicit and implicit processes of stigma evaluation, respectively.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In men with low social anxiety, intranasal oxytocin reduced blame towards stigmatized targets compared with placebo.

    In plain wordsIn men with low social anxiety, nasal oxytocin lowered blame of stigmatized people compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseExplicit COVID-19 stigma, blame towards stigmatized targets in low social anxiety
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    but reduced blame towards the stigmatized targets in low social anxiety individuals under oxytocin compared to placebo treatment
    2 context sentences
    Summary · context
    To address this gap, we performed a double-blind, placebo-controlled, within-subject design study with 70 males, to investigate the effect of intranasal oxytocin (OT) administration on the explicit and implicit processing of disease-related stigma (i.e., COVID-19 stigma).
    Summary · context
    After self-administrated 24 IU of OT or placebo, participants completed a stigma evaluation task and an Implicit Association Test (IAT) to assess the explicit and implicit processes of stigma evaluation, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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