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Study · In vitro (cells) · 2024

7 results

Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression.

Suzuki S, Kitanaka C, Okada M

Anticancer research1 Sept 2024Cited by 4 (Europe PMC)

PMID39197897 (opens in a new tab)DOI10.21873/anticanres.17214 (opens in a new tab)PepBankPUB-39197897
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human glioblastoma cells, bremelanotide reduced survivin expression.

    In plain wordsIn cells, bremelanotide lowered survivin, a protein that helps glioblastoma cells survive.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    DecreaseSurvivin expression
    Study

    humann: not reported in source

    Human glioblastoma cell lines
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bremelanotide reduced survivin expression and induced cell death in glioblastoma cells
    1 context sentence
    Summary · context
    The effects of bremelanotide, a melanocortin receptor agonist, alone or in combination with chemotherapeutic agents, on survivin expression and cell viability were investigated in human glioblastoma cell lines.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human glioblastoma cells, bremelanotide induced cell death.

    In plain wordsIn cells, bremelanotide caused glioblastoma cells to die.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    IncreaseGlioblastoma cell death
    Study

    humann: not reported in source

    Human glioblastoma cell lines
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bremelanotide reduced survivin expression and induced cell death in glioblastoma cells
    1 context sentence
    Summary · context
    The effects of bremelanotide, a melanocortin receptor agonist, alone or in combination with chemotherapeutic agents, on survivin expression and cell viability were investigated in human glioblastoma cell lines.
  3. 03LabIn vitro (cells)Safety outcome

    Bremelanotide reduced survivin and induced glioblastoma cell death at concentrations that were not toxic to normal human cells.

    In plain wordsIn cells, the concentrations of bremelanotide that harmed glioblastoma cells were not toxic to normal human cells.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    No significant changeToxicity to normal human cells
    Study

    humann: not reported in source

    Human glioblastoma cell lines
    Outcome group
    Cell viability and death · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    at concentrations that were not toxic to normal human cells
    1 context sentence
    Summary · context
    The effects of bremelanotide, a melanocortin receptor agonist, alone or in combination with chemotherapeutic agents, on survivin expression and cell viability were investigated in human glioblastoma cell lines.
  4. 04LabIn vitro (cells)Mechanism

    In glioblastoma cells, the survivin reduction and cell death caused by bremelanotide were canceled in the presence of an antagonist of melanocortin receptors 3 and 4.

    In plain wordsIn cells, blocking melanocortin receptors 3 and 4 removed the effects of bremelanotide on survivin and cell death.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    No significant changeEffect of MC3R/MC4R antagonist on bremelanotide actions
    Study

    humann: not reported in source

    Human glioblastoma cell lines
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    both of these effects were canceled in the presence of an antagonist of melanocortin receptors 3 and 4.
    1 context sentence
    Summary · context
    The effects of bremelanotide, a melanocortin receptor agonist, alone or in combination with chemotherapeutic agents, on survivin expression and cell viability were investigated in human glioblastoma cell lines.
  5. 05LabIn vitro (cells)Mechanism

    Forced over-expression of survivin prevented bremelanotide-induced cell death in glioblastoma cells.

    In plain wordsIn cells, adding extra survivin stopped bremelanotide from killing glioblastoma cells.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    No significant changeEffect of survivin over-expression on bremelanotide-induced cell death
    Study

    humann: not reported in source

    Human glioblastoma cell lines
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bremelanotide-induced cell death was prevented by the forced over-expression of survivin in glioblastoma cells, suggesting that bremelanotide induces glioblastoma cell death by inhibiting the expression of survivin.
    1 context sentence
    Summary · context
    The effects of bremelanotide, a melanocortin receptor agonist, alone or in combination with chemotherapeutic agents, on survivin expression and cell viability were investigated in human glioblastoma cell lines.
  6. 06LabIn vitro (cells)Efficacy outcome

    In glioblastoma cells, bremelanotide promoted cell death induced by temozolomide.

    In plain wordsIn cells, bremelanotide increased glioblastoma cell death caused by the chemotherapy drug temozolomide.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    IncreaseCell death with temozolomide
    Study

    humann: not reported in source

    Human glioblastoma cell lines
    Comparator
    Temozolomide alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bremelanotide also promoted cell death induced by chemotherapeutic agents, such as temozolomide and osimertinib.
    1 context sentence
    Summary · context
    The effects of bremelanotide, a melanocortin receptor agonist, alone or in combination with chemotherapeutic agents, on survivin expression and cell viability were investigated in human glioblastoma cell lines.
  7. 07LabIn vitro (cells)Efficacy outcome

    In glioblastoma cells, bremelanotide promoted cell death induced by osimertinib.

    In plain wordsIn cells, bremelanotide increased glioblastoma cell death caused by the drug osimertinib.

    Peptide
    Bremelanotide (PT-141)
    Outcome
    IncreaseCell death with osimertinib
    Study

    humann: not reported in source

    Human glioblastoma cell lines
    Comparator
    Osimertinib alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bremelanotide also promoted cell death induced by chemotherapeutic agents, such as temozolomide and osimertinib.
    1 context sentence
    Summary · context
    The effects of bremelanotide, a melanocortin receptor agonist, alone or in combination with chemotherapeutic agents, on survivin expression and cell viability were investigated in human glioblastoma cell lines.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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