Effects of four-week intranasal oxytocin administration on large-scale brain networks in older adults.

Liu P, Lin T, Fischer H, Feifel D, Ebner NC

Neuropharmacology23 Aug 2024Cited by 2 (Europe PMC)

PMID39182569PMCIDPMC11752694DOI10.1016/j.neuropharm.2024.110130PepBankPUB-39182569

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanRandomized controlled trialMechanism
In healthy older adults, four weeks of intranasal oxytocin reduced resting-state connectivity of the right insula with the salience network compared with placebo.
In plain wordsIn healthy older adults, four weeks of nasal oxytocin lowered connectivity between the right insula and the salience network compared with placebo.
Peptide
Oxytocin
Outcome
DecreaseRight insula connectivity with salience network
Study
n = 60
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · four weeksAs given in this study (human).
Source sentences
Summary
Chronic IN-OT reduced resting-state functional connectivity (rs-FC) of both the right insula and the left middle cingulate cortex with the salience network but enhanced rs-FC of the left medial prefrontal cortex with the default mode network as well as the left thalamus with the basal ganglia-thalamus network.
1 context sentence(design, population, supporting numbers)
Summary · context
To address these research gaps, 60 generally healthy older adults (mean age = 70.12 years, range = 55-83) were randomly assigned to self-administer either IN-OT or placebo twice daily via nasal spray over four weeks.
Report a problemFND-3918256901
02HumanRandomized controlled trialMechanism
In healthy older adults, four weeks of intranasal oxytocin reduced resting-state connectivity of the left middle cingulate cortex with the salience network compared with placebo.
In plain wordsIn healthy older adults, four weeks of nasal oxytocin lowered connectivity between the left middle cingulate cortex and the salience network compared with placebo.
Peptide
Oxytocin
Outcome
DecreaseLeft middle cingulate connectivity with salience network
Study
n = 60
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · four weeksAs given in this study (human).
Source sentences
Summary
Chronic IN-OT reduced resting-state functional connectivity (rs-FC) of both the right insula and the left middle cingulate cortex with the salience network but enhanced rs-FC of the left medial prefrontal cortex with the default mode network as well as the left thalamus with the basal ganglia-thalamus network.
1 context sentence(design, population, supporting numbers)
Summary · context
To address these research gaps, 60 generally healthy older adults (mean age = 70.12 years, range = 55-83) were randomly assigned to self-administer either IN-OT or placebo twice daily via nasal spray over four weeks.
Report a problemFND-3918256902
03HumanRandomized controlled trialMechanism
In healthy older adults, four weeks of intranasal oxytocin enhanced resting-state connectivity of the left medial prefrontal cortex with the default mode network compared with placebo.
In plain wordsIn healthy older adults, four weeks of nasal oxytocin raised connectivity between the left medial prefrontal cortex and the default mode network compared with placebo.
Peptide
Oxytocin
Outcome
IncreaseLeft medial prefrontal connectivity with default mode network
Study
n = 60
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · four weeksAs given in this study (human).
Source sentences
Summary
Chronic IN-OT reduced resting-state functional connectivity (rs-FC) of both the right insula and the left middle cingulate cortex with the salience network but enhanced rs-FC of the left medial prefrontal cortex with the default mode network as well as the left thalamus with the basal ganglia-thalamus network.
1 context sentence(design, population, supporting numbers)
Summary · context
To address these research gaps, 60 generally healthy older adults (mean age = 70.12 years, range = 55-83) were randomly assigned to self-administer either IN-OT or placebo twice daily via nasal spray over four weeks.
Report a problemFND-3918256903
04HumanRandomized controlled trialMechanism
In healthy older adults, four weeks of intranasal oxytocin enhanced resting-state connectivity of the left thalamus with the basal ganglia-thalamus network compared with placebo.
In plain wordsIn healthy older adults, four weeks of nasal oxytocin raised connectivity between the left thalamus and the basal ganglia-thalamus network compared with placebo.
Peptide
Oxytocin
Outcome
IncreaseLeft thalamus connectivity with basal ganglia-thalamus network
Study
n = 60
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · four weeksAs given in this study (human).
Source sentences
Summary
Chronic IN-OT reduced resting-state functional connectivity (rs-FC) of both the right insula and the left middle cingulate cortex with the salience network but enhanced rs-FC of the left medial prefrontal cortex with the default mode network as well as the left thalamus with the basal ganglia-thalamus network.
1 context sentence(design, population, supporting numbers)
Summary · context
To address these research gaps, 60 generally healthy older adults (mean age = 70.12 years, range = 55-83) were randomly assigned to self-administer either IN-OT or placebo twice daily via nasal spray over four weeks.
Report a problemFND-3918256904
05HumanRandomized controlled trialMechanism
In healthy older adults, four weeks of intranasal oxytocin did not significantly change between-network resting-state connectivity compared with placebo.
In plain wordsIn healthy older adults, four weeks of nasal oxytocin did not significantly change connectivity between brain networks compared with placebo.
Peptide
Oxytocin
Outcome
No significant changeBetween-network connectivity
Study
n = 60
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · four weeksAs given in this study (human).
Source sentences
Summary
No significant chronic IN-OT effects were observed for between-network rs-FC.
1 context sentence(design, population, supporting numbers)
Summary · context
To address these research gaps, 60 generally healthy older adults (mean age = 70.12 years, range = 55-83) were randomly assigned to self-administer either IN-OT or placebo twice daily via nasal spray over four weeks.
Report a problemFND-3918256905
06HumanRandomized controlled trialMechanism
In healthy older adults, four weeks of intranasal oxytocin increased selective connectivity of the basal ganglia-thalamus network with the salience network and the default mode network compared with placebo.
In plain wordsIn healthy older adults, four weeks of nasal oxytocin increased selective connectivity of the basal ganglia-thalamus network with two other brain networks compared with placebo.
Peptide
Oxytocin
Outcome
IncreaseSelective connectivity of basal ganglia-thalamus network with salience and default mode networks
Study
n = 60
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · four weeksAs given in this study (human).
Source sentences
Summary
chronic IN-OT increased selective rs-FC of the basal ganglia-thalamus network with the salience network and the default mode network
1 context sentence(design, population, supporting numbers)
Summary · context
To address these research gaps, 60 generally healthy older adults (mean age = 70.12 years, range = 55-83) were randomly assigned to self-administer either IN-OT or placebo twice daily via nasal spray over four weeks.
Report a problemFND-3918256906
07HumanRandomized controlled trialMechanism
In healthy older adults, some connectivity changes, such as reduced right insula connectivity with the salience network, were more pronounced after chronic than after acute intranasal oxytocin.
In plain wordsIn healthy older adults, some brain connectivity changes were stronger after four weeks of nasal oxytocin than after a single dose.
Peptide
Oxytocin
Outcome
MixedChronic versus acute intranasal oxytocin effects on network connectivity
Study
n: not reported in source
Comparator
Acute intranasal oxytocin
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · four weeksAs given in this study (human).
Source sentences
Summary
Directly comparing chronic vs. acute IN-OT, reduced rs-FC of the right insula with the salience network and between the default mode network and the basal ganglia-thalamus network, and greater selective rs-FC of the salience network with the default mode network and the basal ganglia-thalamus networ…
1 context sentence(design, population, supporting numbers)
Summary · context
To address these research gaps, 60 generally healthy older adults (mean age = 70.12 years, range = 55-83) were randomly assigned to self-administer either IN-OT or placebo twice daily via nasal spray over four weeks.
Report a problemFND-3918256907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

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