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Study · Animal study (in vivo) · mouse · 2024

2 results

Dulaglutide rescues the elevated testicular dysfunction in a mouse model of high-fat diet-induced obesity.

Attia SM, Alshamrani AA, Ahmad SF, Albekairi NA, Nadeem A, Attia MSM, Ansari MA, Alqahtani F, Bakheet SA, Harisa GI

Mutation research. Genetic toxicology and environmental mutagenesis23 Jul 2024Cited by 1 (Europe PMC)

PMID39147447 (opens in a new tab)DOI10.1016/j.mrgentox.2024.503805 (opens in a new tab)PepBankPUB-39147447
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, dulaglutide restored the collectively reported disturbed testicular parameters to control levels.

    In plain wordsIn obese mice, dulaglutide restored the reported group of disturbed testicular measures to control levels.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    MixedDisturbed testicular parameters
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Comparator
    Untreated obese mice and control levels
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.6 mg/kg/day · injection, site not reported · five weeksAs given in this study (mouse).

    Source sentences

    Summary
    In obese mice, dulaglutide injection efficiently restored all disturbed parameters to their control levels.
    3 context sentences
    Summary · context
    Untreated obese mice had a lower testes/body weight ratio, more sperm DNA damage, diakinesis-metaphase I chromosomal abnormalities, a lower sperm count/motility, more cell morphological defects, and an altered testicular redox balance.
    Summary · context
    We used a well-known animal model of high-fat diet-induced obesity in this investigation, and testicular dysfunction was determined by sperm DNA damage, spermatocyte chromosomal abnormalities, and spermiogram analysis.
    Summary · context
    Following a 12-week high-fat diet challenge, mice were randomly assigned to dulaglutide (0.6 mg/kg/day) or saline treatments for five weeks.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In healthy mice, dulaglutide caused no significant harmful effects under the applied regimen.

    In plain wordsIn healthy mice, dulaglutide caused no significant harmful effects under the tested regimen.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    No significant changeHarmful effects in healthy mice
    Study

    mousen: not reported in source

    Healthy mice
    Outcome group
    Adverse events · Whole body
    Studied dose
    0.6 mg/kg/day · injection, site not reported · five weeksAs given in this study (mouse).

    Source sentences

    Summary
    Dulaglutide injection into healthy mice exhibited no significant harmful effects at the applied regimen.
    2 context sentences
    Summary · context
    We used a well-known animal model of high-fat diet-induced obesity in this investigation, and testicular dysfunction was determined by sperm DNA damage, spermatocyte chromosomal abnormalities, and spermiogram analysis.
    Summary · context
    Following a 12-week high-fat diet challenge, mice were randomly assigned to dulaglutide (0.6 mg/kg/day) or saline treatments for five weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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