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Study · Not a test of the peptide alone · 2024

6 results

Unlocking the psycho-social-dermal axis: A double blinded randomized placebo controlled study unveiling the influence of a novel topical formulation on skin quality, attractiveness, quality of life, and sexual satisfaction.

Fabi SG, Cattelan L, Caughlin B, Pérez JS, Cirrincione M, Dayan S

Journal of cosmetic dermatology29 Jul 2024Cited by 5 (Europe PMC)

PMID39073288 (opens in a new tab)DOI10.1111/jocd.16496 (opens in a new tab)PepBankPUB-39073288
Publisher pagePubMedAsk about this study
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Summary

BackgroundImproved skin appearance is closely linked to higher self-esteem, favorable first impressions, and enhanced quality of life, with skincare products often being formulated with biostimulatory and regenerative ingredients to both enhance skin health and provide psychological benefits. Certain components, such as phospholipids and botanicals, may not only improve skin quality, but also impact mood, romantic bonding, and sexual attraction.AimsTo assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways.Patients/methodsIn this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks. Skin assessments, standardized photography, first impression ratings, and questionnaires on confidence and sexual satisfaction were conducted.ResultsThirty-nine subjects completed the study and demonstrated a statistically significant improvement in skin quality following 4 and 8 weeks of use, with improvements of greater magnitude demonstrated with a longer duration of use. Product users projected a better first impression and appeared on average 3 years younger than their actual age, with 86% of subjects reporting increased confidence. Product users found random people of the opposite sex to be more attractive 88% of the time and reported improvement in sexual satisfaction in 90% of the categories.ConclusionsThe use of this novel topical product culminated in statistically significant improvements in skin quality, confidence, sexual relationship satisfaction, perceived attractiveness, and youthfulness, highlighting its potential in anti-aging and mood enhancement.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In adult women, a topical skincare product with several active components improved skin quality after 4 and 8 weeks, with larger gains after longer use.

    In plain wordsIn women, a skincare product with several active parts improved skin quality after 4 and 8 weeks, more so with longer use.

    Peptide
    Oxytocin
    Outcome
    IncreaseSkin quality
    Study

    n = 39

    Comparator
    Placebo
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Thirty-nine subjects completed the study and demonstrated a statistically significant improvement in skin quality following 4 and 8 weeks of use, with improvements of greater magnitude demonstrated with a longer duration of use.
    2 context sentences
    Summary · context
    To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways.
    Summary · context
    In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In adult women, users of a multi-component topical product projected a better first impression.

    In plain wordsIn women, people using a skincare product with several active parts gave a better first impression.

    Peptide
    Oxytocin
    Outcome
    IncreaseFirst impression rating
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood

    Source sentences

    Summary
    Product users projected a better first impression
    2 context sentences
    Summary · context
    To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways.
    Summary · context
    In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In adult women, users of a multi-component topical product appeared on average 3 years younger than their actual age.

    In plain wordsIn women, people using a skincare product with several active parts looked about 3 years younger than their real age.

    Peptide
    Oxytocin
    Outcome
    DecreaseApparent age
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Apparent age difference
    −3 years
    product users

    Source sentences

    Summary
    appeared on average 3 years younger than their actual age
    2 context sentences
    Summary · context
    To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways.
    Summary · context
    In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 04HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    In adult women, 86% of users of a multi-component topical product reported increased confidence.

    In plain wordsIn women using a skincare product with several active parts, 86% reported more confidence.

    Peptide
    Oxytocin
    Outcome
    IncreaseSelf-reported confidence
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood

    Measurements

    Subjects reporting increased confidence
    86%
    product users

    Source sentences

    Summary
    with 86% of subjects reporting increased confidence.
    2 context sentences
    Summary · context
    To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways.
    Summary · context
    In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  5. 05HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    Users of a multi-component topical product found random people of the opposite sex more attractive 88% of the time.

    In plain wordsPeople using a skincare product with several active parts found random people of the opposite sex more attractive 88% of the time.

    Peptide
    Oxytocin
    Outcome
    IncreasePerceived attractiveness of opposite sex
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Reproductive and sexual health

    Measurements

    Opposite-sex attractiveness rated higher
    88%
    product users

    Source sentences

    Summary
    Product users found random people of the opposite sex to be more attractive 88% of the time
    2 context sentences
    Summary · context
    To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways.
    Summary · context
    In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  6. 06HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome

    Users of a multi-component topical product reported improved sexual satisfaction in 90% of the categories.

    In plain wordsPeople using a skincare product with several active parts reported better sexual satisfaction in 90% of the categories.

    Peptide
    Oxytocin
    Outcome
    IncreaseSexual satisfaction
    Study

    n: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health

    Measurements

    Categories with improved sexual satisfaction
    90%
    product users

    Source sentences

    Summary
    reported improvement in sexual satisfaction in 90% of the categories.
    2 context sentences
    Summary · context
    To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways.
    Summary · context
    In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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