NAD⁺ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer.

Yang M, Wang B, Hou W, Zeng H, He W, Zhang XK, Yan D, Yu H, Huang L, Pei L, Li K, Qin H, Lin T, Huang J

Journal for immunotherapy of cancer27 Jul 2024Cited by 35 (Europe PMC)

PMID39067875PMCIDPMC11284830DOI10.1136/jitc-2024-009281PepBankPUB-39067875

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In bladder cancer mouse models, 5-Amino-1-methylquinolinium iodide significantly reduced tumor growth.
In plain wordsIn mice with bladder cancer, 5-Amino-1-methylquinolinium iodide significantly reduced tumor growth.
Peptide
5-amino-1MQ
Outcome
DecreaseTumor growth
Study
mousen: not reported in source
urothelial bladder cancer mouse models
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Targeting NNMT using the inhibitor 5-Amino-1-methylquinolinium iodide significantly reduced tumor growth and enhanced the apoptotic effects of the anti-PD-L1 antibody in UBC mouse models.
Report a problemFND-3906787501

Studies that did not test the peptide alone1

In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking 5-amino-1MQ.

02AnimalNot a test of 5-amino-1MQ aloneAnimal study (in vivo)Efficacy outcome
In bladder cancer mouse models, treatment involving 5-Amino-1-methylquinolinium iodide enhanced anti-PD-L1 antibody apoptotic effects.
In plain wordsIn mice with bladder cancer, treatment involving 5-Amino-1-methylquinolinium iodide enhanced the antibody's cell death effects.
Peptide
5-amino-1MQ
Outcome
IncreaseAnti-PD-L1-associated apoptosis
Study
mousen: not reported in source
urothelial bladder cancer mouse models
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Targeting NNMT using the inhibitor 5-Amino-1-methylquinolinium iodide significantly reduced tumor growth and enhanced the apoptotic effects of the anti-PD-L1 antibody in UBC mouse models.
In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.
Report a problemFND-3906787502

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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