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Study · In vitro (cells) · 2024

5 results

Mechano-growth factor regulates periodontal ligament stem cell proliferation and differentiation through Fyn-RhoA-YAP signaling.

Feng F, Tu T, Wang H, Song R, Li J, Zhu Y, Zhang S, Zhang M, Zhao Y, Liu Y

Biochemical and biophysical research communications25 Jul 2024Cited by 3 (Europe PMC)

PMID39067248 (opens in a new tab)DOI10.1016/j.bbrc.2024.150450 (opens in a new tab)PepBankPUB-39067248
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In periodontal ligament stem cells, MGF promoted proliferation by inducing Fyn-YAP Y357 phosphorylation.

    In plain wordsIn lab tests, MGF made periodontal ligament stem cells multiply more.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreasePDLSC proliferation
    Study

    n: not reported in source

    Periodontal ligament stem cells (PDLSCs)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that MGF plays a regulatory role in promoting PDLSCs proliferation and fibrogenic differentiation by inducing Fyn-YAPY357 phosphorylation but not LATS1-YAP S127 phosphorylation.
    1 context sentence
    Summary · context
    Initially, we investigated how MGF impacts cell growth and differentiation, and the relationship with the activation of Fyn-p-YAPY357 and LATS1-p-YAPS127.
  2. 02LabIn vitro (cells)Efficacy outcome

    In periodontal ligament stem cells, MGF promoted fibrogenic differentiation by inducing Fyn-YAP Y357 phosphorylation.

    In plain wordsIn lab tests, MGF pushed periodontal ligament stem cells to develop into fibroblast-like cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreasePDLSC fibrogenic differentiation
    Study

    n: not reported in source

    Periodontal ligament stem cells (PDLSCs)
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that MGF plays a regulatory role in promoting PDLSCs proliferation and fibrogenic differentiation by inducing Fyn-YAPY357 phosphorylation but not LATS1-YAP S127 phosphorylation.
    1 context sentence
    Summary · context
    Initially, we investigated how MGF impacts cell growth and differentiation, and the relationship with the activation of Fyn-p-YAPY357 and LATS1-p-YAPS127.
  3. 03LabIn vitro (cells)Mechanism

    In periodontal ligament stem cells, MGF induced Fyn-YAP Y357 phosphorylation.

    In plain wordsIn lab tests, MGF activated the Fyn-YAP signal in periodontal ligament stem cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseFyn-YAP Y357 phosphorylation
    Study

    n: not reported in source

    Periodontal ligament stem cells (PDLSCs)
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that MGF plays a regulatory role in promoting PDLSCs proliferation and fibrogenic differentiation by inducing Fyn-YAPY357 phosphorylation but not LATS1-YAP S127 phosphorylation.
    1 context sentence
    Summary · context
    Initially, we investigated how MGF impacts cell growth and differentiation, and the relationship with the activation of Fyn-p-YAPY357 and LATS1-p-YAPS127.
  4. 04LabIn vitro (cells)Mechanism

    In periodontal ligament stem cells, MGF did not induce LATS1-YAP S127 phosphorylation.

    In plain wordsIn lab tests, MGF did not activate the LATS1-YAP signal in periodontal ligament stem cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeLATS1-YAP S127 phosphorylation
    Study

    n: not reported in source

    Periodontal ligament stem cells (PDLSCs)
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study revealed that MGF plays a regulatory role in promoting PDLSCs proliferation and fibrogenic differentiation by inducing Fyn-YAPY357 phosphorylation but not LATS1-YAP S127 phosphorylation.
    1 context sentence
    Summary · context
    Initially, we investigated how MGF impacts cell growth and differentiation, and the relationship with the activation of Fyn-p-YAPY357 and LATS1-p-YAPS127.
  5. 05LabIn vitro (cells)Mechanism

    In periodontal ligament stem cells, Fyn did not activate YAP directly but through RhoA in response to MGF stimulation.

    In plain wordsIn lab tests, Fyn activated YAP through RhoA, not directly, after MGF stimulation.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableRole of RhoA in Fyn-YAP activation by MGF
    Study

    n: not reported in source

    Periodontal ligament stem cells (PDLSCs)
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, the results indicated that Fyn could not activate YAP directly but rather activated YAP through RhoA in response to MGF stimulation.
    1 context sentence
    Summary · context
    Initially, we investigated how MGF impacts cell growth and differentiation, and the relationship with the activation of Fyn-p-YAPY357 and LATS1-p-YAPS127.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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