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Study · Animal study (in vivo) · mouse · 2024

9 results

Dulaglutide reduces oxidative DNA damage and hypermethylation in the somatic cells of mice fed a high-energy diet by restoring redox balance, inflammatory responses, and DNA repair gene expressions.

Attia SM, Alshamrani AA, Ahmad SF, Albekairi NA, Nadeem A, Attia MSM, Ansari MA, Almutairi F, Bakheet SA

Journal of biochemical and molecular toxicology1 Jul 2024Cited by 3 (Europe PMC)

PMID38963172 (opens in a new tab)DOI10.1002/jbt.23764 (opens in a new tab)PepBankPUB-38963172
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In mice, dulaglutide did not exhibit genotoxicity under the investigated conditions.

    In plain wordsIn mice, dulaglutide did not show genetic toxicity under the tested conditions.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    Not applicableGenotoxicity
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    The findings demonstrated that dulaglutide does not exhibit genotoxicity in the investigated conditions.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice fed a high-fat diet, dulaglutide treatment was followed by low DNA damage.

    In plain wordsIn mice fed a high-fat diet, DNA damage was low after dulaglutide treatment.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseDNA damage
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Genome stability · Whole body
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Following dulaglutide administration, animals fed a high-fat diet demonstrated low DNA damage, less oxidation and methylation of DNA bases, restored redox balance, and improved inflammatory responses.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice fed a high-fat diet, dulaglutide treatment was followed by less DNA base oxidation.

    In plain wordsIn mice fed a high-fat diet, DNA base oxidation was lower after dulaglutide treatment.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseDNA base oxidation
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Genome stability · Whole body
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Following dulaglutide administration, animals fed a high-fat diet demonstrated low DNA damage, less oxidation and methylation of DNA bases, restored redox balance, and improved inflammatory responses.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice fed a high-fat diet, dulaglutide treatment was followed by less DNA base methylation.

    In plain wordsIn mice fed a high-fat diet, DNA base methylation was lower after dulaglutide treatment.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseDNA base methylation
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Gene expression · Whole body
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Following dulaglutide administration, animals fed a high-fat diet demonstrated low DNA damage, less oxidation and methylation of DNA bases, restored redox balance, and improved inflammatory responses.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice fed a high-fat diet, dulaglutide restored redox balance.

    In plain wordsIn mice fed a high-fat diet, dulaglutide restored redox balance.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    MixedRedox balance
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Following dulaglutide administration, animals fed a high-fat diet demonstrated low DNA damage, less oxidation and methylation of DNA bases, restored redox balance, and improved inflammatory responses.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice fed a high-fat diet, dulaglutide improved inflammatory responses.

    In plain wordsIn mice fed a high-fat diet, dulaglutide improved inflammatory responses.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    MixedInflammatory responses
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Following dulaglutide administration, animals fed a high-fat diet demonstrated low DNA damage, less oxidation and methylation of DNA bases, restored redox balance, and improved inflammatory responses.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In obese mice, dulaglutide restored upregulated DNMT1 gene expression.

    In plain wordsIn obese mice, dulaglutide restored abnormally increased DNMT1 gene activity.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseDNMT1 expression
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In addition, dulaglutide treatment restored the upregulated DNMT1, Ogg1, and p53 gene expression.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In obese mice, dulaglutide restored upregulated Ogg1 gene expression.

    In plain wordsIn obese mice, dulaglutide restored abnormally increased Ogg1 gene activity.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseOgg1 expression
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In addition, dulaglutide treatment restored the upregulated DNMT1, Ogg1, and p53 gene expression.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In obese mice, dulaglutide restored upregulated p53 gene expression.

    In plain wordsIn obese mice, dulaglutide restored abnormally increased p53 gene activity.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    Decreasep53 expression
    Study

    mousen: not reported in source

    High-fat-diet obesity
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In addition, dulaglutide treatment restored the upregulated DNMT1, Ogg1, and p53 gene expression.
    1 context sentence
    Summary · context
    Mice were administered a low-fat or high-fat diet for 12 weeks, followed by a 5-week treatment with dulaglutide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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