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Study · Animal study (in vivo) · mouse · 2024

2 results

Single-Cell RNA Sequencing Reveals Transcriptional Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE.

Quan M, Zhang H, Han X, Ba Y, Cui X, Bi Y, Yi L, Li B

Neurology(R) neuroimmunology & neuroinflammation2 Jul 2024Cited by 12 (Europe PMC)

PMID38954781 (opens in a new tab)PMCIDPMC11221915 (opens in a new tab)DOI10.1212/nxi.0000000000200278 (opens in a new tab)PepBankPUB-38954781
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In EAE mice, LR12 prevented neutrophil migration in vivo.

    In plain wordsIn mice with EAE, LR12 prevented neutrophil migration.

    Peptide
    Nangibotide
    Outcome
    DecreaseNeutrophil migration
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Inhibiting TREM1 with LR12 prevents neutrophil migration both in vivo and in vitro.
    1 context sentence
    Summary · context
    Notably, we observed a substantial increase in the neutrophil population in EAE mice, with a particular emphasis on the significant rise within the CLNs.
  2. 02LabIn vitro (cells)Mechanism

    In vitro, LR12 prevented neutrophil migration.

    In plain wordsIn cells, LR12 prevented neutrophil migration.

    Peptide
    Nangibotide
    Outcome
    DecreaseNeutrophil migration
    Study

    n: not reported in source

    Neutrophils in vitro
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Inhibiting TREM1 with LR12 prevents neutrophil migration both in vivo and in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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