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Study · Animal study (in vivo) · mouse · 2024

3 results

Microglial EPOR Contribute to Sevoflurane-induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice.

He D, Shi X, Liang L, Zhao Y, Ma S, Cao S, Liu B, Gao Z, Zhang X, Fan Z, Kuang F, Zhang H

Neuroscience bulletin21 Jun 2024Cited by 7 (Europe PMC)

PMID38907076 (opens in a new tab)PMCIDPMC11625042 (opens in a new tab)DOI10.1007/s12264-024-01248-5 (opens in a new tab)PepBankPUB-38907076
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Summary

Clinical researches including the Mayo Anesthesia Safety in Kids (MASK) study have found that children undergoing multiple anesthesia may have a higher risk of fine motor control difficulties. However, the underlying mechanisms remain elusive. Here, we report that erythropoietin receptor (EPOR), a microglial receptor associated with phagocytic activity, was significantly downregulated in the medial prefrontal cortex of young mice after multiple sevoflurane anesthesia exposure. Importantly, we found that the inhibited erythropoietin (EPO)/EPOR signaling axis led to microglial polarization, excessive excitatory synaptic pruning, and abnormal fine motor control skills in mice with multiple anesthesia exposure, and those above-mentioned situations were fully reversed by supplementing EPO-derived peptide ARA290 by intraperitoneal injection. Together, the microglial EPOR was identified as a key mediator regulating early synaptic development in this study, which impacted sevoflurane-induced fine motor dysfunction. Moreover, ARA290 might serve as a new treatment against neurotoxicity induced by general anesthesia in clinical practice by targeting the EPO/EPOR signaling pathway.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with multiple sevoflurane exposure, ARA290 fully reversed the microglial polarization.

    In plain wordsIn mice exposed to repeated anesthesia, ARA290 reversed changes in microglia, the brain's immune cells.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    Direction not reportedMicroglial polarization
    Study

    mousen: not reported in source

    Mice with multiple sevoflurane anesthesia exposure
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    we found that the inhibited erythropoietin (EPO)/EPOR signaling axis led to microglial polarization, excessive excitatory synaptic pruning, and abnormal fine motor control skills in mice with multiple anesthesia exposure, and those above-mentioned situations were fully reversed by supplementing EPO-derived peptide ARA290 by intraperitoneal injection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with multiple sevoflurane exposure, ARA290 fully reversed excessive excitatory synaptic pruning.

    In plain wordsIn mice exposed to repeated anesthesia, ARA290 reversed excessive pruning of nerve connections.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseExcitatory synaptic pruning
    Study

    mousen: not reported in source

    Mice with multiple sevoflurane anesthesia exposure
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    we found that the inhibited erythropoietin (EPO)/EPOR signaling axis led to microglial polarization, excessive excitatory synaptic pruning, and abnormal fine motor control skills in mice with multiple anesthesia exposure, and those above-mentioned situations were fully reversed by supplementing EPO-derived peptide ARA290 by intraperitoneal injection.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with multiple sevoflurane exposure, ARA290 fully reversed abnormal fine motor control skills.

    In plain wordsIn mice exposed to repeated anesthesia, ARA290 reversed problems with fine movement control.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseFine motor control deficit
    Study

    mousen: not reported in source

    Mice with multiple sevoflurane anesthesia exposure
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    we found that the inhibited erythropoietin (EPO)/EPOR signaling axis led to microglial polarization, excessive excitatory synaptic pruning, and abnormal fine motor control skills in mice with multiple anesthesia exposure, and those above-mentioned situations were fully reversed by supplementing EPO-derived peptide ARA290 by intraperitoneal injection.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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