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Study · Animal study (in vivo) · mouse · 2024

5 results

The glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6.

Bian Y, Deng M, Liu J, Li J, Zhang Q, Wang Z, Liao L, Miao J, Li R, Zhou X, Hou G

Redox biology14 Jun 2024Cited by 7 (Europe PMC)

PMID38879894 (opens in a new tab)PMCIDPMC11228880 (opens in a new tab)DOI10.1016/j.redox.2024.103237 (opens in a new tab)PepBankPUB-38879894
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with experimental silicosis, GHK‑Cu attenuated lung inflammation.

    In plain wordsIn mice with silicosis, GHK‑Cu reduced lung inflammation.

    Peptide
    GHK-Cu
    Outcome
    DecreaseLung inflammation in silicosis
    Study

    mousen: not reported in source

    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu can bind to PRDX6, thus attenuating lung inflammation and fibrosis in silicosis mice
    1 context sentence
    Summary · context
    An experimental silicosis mouse model was established to observe the effects of GHK-Cu on lung inflammation and fibrosis.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with experimental silicosis, GHK‑Cu attenuated lung fibrosis.

    In plain wordsIn mice with silicosis, GHK‑Cu reduced lung scarring.

    Peptide
    GHK-Cu
    Outcome
    DecreaseLung fibrosis in silicosis
    Study

    mousen: not reported in source

    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHK-Cu can bind to PRDX6, thus attenuating lung inflammation and fibrosis in silicosis mice
    1 context sentence
    Summary · context
    An experimental silicosis mouse model was established to observe the effects of GHK-Cu on lung inflammation and fibrosis.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In mice with experimental silicosis, GHK‑Cu treatment was without significant systemic toxicity.

    In plain wordsIn mice with silicosis, GHK‑Cu caused no significant toxicity in the whole body.

    Peptide
    GHK-Cu
    Outcome
    No significant changeSystemic toxicity
    Study

    mousen: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    without significant systemic toxicity.
    1 context sentence
    Summary · context
    An experimental silicosis mouse model was established to observe the effects of GHK-Cu on lung inflammation and fibrosis.
  4. 04LabIn vitro (cells)Mechanism

    In RAW264.7 alveolar macrophage cells, GHK‑Cu inhibited crystalline silica-induced oxidative stress, partly relating to its effects in silicosis mice.

    In plain wordsIn cells, GHK‑Cu reduced oxidative stress caused by silica in a type of lung immune cell.

    Peptide
    GHK-Cu
    Outcome
    DecreaseCrystalline silica-induced oxidative stress in alveolar macrophages
    Study

    n: not reported in source

    RAW264.7 cell line
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These effects were partly related to the inhibition of the CS-induced oxidative stress in AM induced by GHK-Cu.
    1 context sentence
    Summary · context
    Moreover, the effects of GHK-Cu on the alveolar macrophages (AM) were examined using the RAW264.7 cell line.
  5. 05LabOther designMechanism

    GHK‑Cu was reported to bind its molecular target peroxiredoxin 6 (PRDX6).

    In plain wordsIn lab tests, GHK‑Cu was found to bind a protein called PRDX6.

    Peptide
    GHK-Cu
    Outcome
    Not applicableBinding to peroxiredoxin 6 (PRDX6)
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Its molecular target, peroxiredoxin 6 (PRDX6), has been identified, and GHK-Cu can bind to PRDX6, thus attenuating lung inflammation and fibrosis in silicosis mice without significant systemic toxicity.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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