Mesenchymal stem cell therapy using Pal-KTTKS-enriched carboxylated cellulose improves burn wound in rat model.

Rasouli M, Shahghasempour L, Shirbaghaee Z, Hosseinzadeh S, Abbaszadeh HA, Fattahi R, Ranjbari J, Soleimani M

Archives of dermatological research8 Jun 2024Cited by 5 (Europe PMC)

PMID38850353DOI10.1007/s00403-024-03082-1PepBankPUB-38850353

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with burns, pal-KTTKS-enriched cellulose composites significantly alleviated inflammation.
In plain wordsIn rats with burns, pal-KTTKS-enriched cellulose composites reduced inflammation.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
DecreaseInflammation with KTTKS-CBC
Study
ratn: not reported in source
Burn wounds
Outcome group
Inflammation markers · Skin and wound
Studied dose
Dose not stated · Wound dressing implantationAs given in this study (rat).
Source sentences
Summary
We found that KTTKS-CBC and MSC-KTTKS-CBC composites exhibited significantly better wound healing capability, as evidenced by significantly alleviated inflammation, increased collagen deposition, improved angiogenesis, and considerably accelerated wound closure.
1 context sentence(design, population, supporting numbers)
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
Report a problemFND-3885035303
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with burns, pal-KTTKS-enriched cellulose composites increased collagen deposition.
In plain wordsIn rats with burns, pal-KTTKS-enriched cellulose composites increased collagen deposition.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCollagen deposition with KTTKS-CBC
Study
ratn: not reported in source
Burn wounds
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · Wound dressing implantationAs given in this study (rat).
Source sentences
Summary
We found that KTTKS-CBC and MSC-KTTKS-CBC composites exhibited significantly better wound healing capability, as evidenced by significantly alleviated inflammation, increased collagen deposition, improved angiogenesis, and considerably accelerated wound closure.
1 context sentence(design, population, supporting numbers)
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
Report a problemFND-3885035304
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with burns, pal-KTTKS-enriched cellulose composites improved angiogenesis.
In plain wordsIn rats with burns, pal-KTTKS-enriched cellulose composites improved blood vessel formation.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseAngiogenesis with KTTKS-CBC
Study
ratn: not reported in source
Burn wounds
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · Wound dressing implantationAs given in this study (rat).
Source sentences
Summary
We found that KTTKS-CBC and MSC-KTTKS-CBC composites exhibited significantly better wound healing capability, as evidenced by significantly alleviated inflammation, increased collagen deposition, improved angiogenesis, and considerably accelerated wound closure.
1 context sentence(design, population, supporting numbers)
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
Report a problemFND-3885035305
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with burns, pal-KTTKS-enriched cellulose composites accelerated wound closure.
In plain wordsIn rats with burns, pal-KTTKS-enriched cellulose composites accelerated wound closure.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseWound closure with KTTKS-CBC
Study
ratn: not reported in source
Burn wounds
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · Wound dressing implantationAs given in this study (rat).
Source sentences
Summary
We found that KTTKS-CBC and MSC-KTTKS-CBC composites exhibited significantly better wound healing capability, as evidenced by significantly alleviated inflammation, increased collagen deposition, improved angiogenesis, and considerably accelerated wound closure.
1 context sentence(design, population, supporting numbers)
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
Report a problemFND-3885035306

Studies that did not test the peptide alone8

In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

05AnimalNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneAnimal study (in vivo)Efficacy outcome
In rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites significantly alleviated inflammation.
In plain wordsIn rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites reduced inflammation.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
DecreaseInflammation with MSC-KTTKS-CBC
Study
ratn: not reported in source
Burn wounds
Outcome group
Inflammation markers · Skin and wound
Source sentences
Summary
We found that KTTKS-CBC and MSC-KTTKS-CBC composites exhibited significantly better wound healing capability, as evidenced by significantly alleviated inflammation, increased collagen deposition, improved angiogenesis, and considerably accelerated wound closure.
2 context sentences(design, population, supporting numbers)
Summary · context
To boost wound-healing performance, adipose-derived mesenchymal stem cells (MSC) were seeded on the pal-KTTKS-enriched composites to be implanted in a rat model of burn wound healing.
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3885035307
06AnimalNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneAnimal study (in vivo)Efficacy outcome
In rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites increased collagen deposition.
In plain wordsIn rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites increased collagen deposition.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCollagen deposition with MSC-KTTKS-CBC
Study
ratn: not reported in source
Burn wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
We found that KTTKS-CBC and MSC-KTTKS-CBC composites exhibited significantly better wound healing capability, as evidenced by significantly alleviated inflammation, increased collagen deposition, improved angiogenesis, and considerably accelerated wound closure.
2 context sentences(design, population, supporting numbers)
Summary · context
To boost wound-healing performance, adipose-derived mesenchymal stem cells (MSC) were seeded on the pal-KTTKS-enriched composites to be implanted in a rat model of burn wound healing.
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3885035308
07AnimalNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneAnimal study (in vivo)Efficacy outcome
In rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites improved angiogenesis.
In plain wordsIn rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites improved blood vessel formation.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseAngiogenesis with MSC-KTTKS-CBC
Study
ratn: not reported in source
Burn wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
We found that KTTKS-CBC and MSC-KTTKS-CBC composites exhibited significantly better wound healing capability, as evidenced by significantly alleviated inflammation, increased collagen deposition, improved angiogenesis, and considerably accelerated wound closure.
2 context sentences(design, population, supporting numbers)
Summary · context
To boost wound-healing performance, adipose-derived mesenchymal stem cells (MSC) were seeded on the pal-KTTKS-enriched composites to be implanted in a rat model of burn wound healing.
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3885035309
08AnimalNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneAnimal study (in vivo)Efficacy outcome
In rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites accelerated wound closure.
In plain wordsIn rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites accelerated wound closure.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseWound closure with MSC-KTTKS-CBC
Study
ratn: not reported in source
Burn wounds
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
We found that KTTKS-CBC and MSC-KTTKS-CBC composites exhibited significantly better wound healing capability, as evidenced by significantly alleviated inflammation, increased collagen deposition, improved angiogenesis, and considerably accelerated wound closure.
2 context sentences(design, population, supporting numbers)
Summary · context
To boost wound-healing performance, adipose-derived mesenchymal stem cells (MSC) were seeded on the pal-KTTKS-enriched composites to be implanted in a rat model of burn wound healing.
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3885035310
09AnimalNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneAnimal study (in vivo)Efficacy outcome
In rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites had the best wound healing among all four groups.
In plain wordsIn rats with burns, stem-cell-loaded pal-KTTKS-cellulose composites had the best wound healing among all four groups.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseOverall wound healing performance
Study
ratn: not reported in source
Burn wounds
Comparator
Vaseline gauze, CBC, and KTTKS-CBC
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Nevertheless, the best wound-healing performance was observed in the MSC-KTTKS-CBC groups among all four groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Healthy male rats were randomly divided into four groups and wound-healing performance of Vaseline gauze (control), carboxylated cellulose (CBC), pal-KTTKS-enriched CBC (KTTKS-CBC), and MSCs seeded on the KTTKS-CBC composites (MSC-KTTKS-CBC) were evaluated on days 3, 7, and 14 post-implantation.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3885035311
10LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Activity measurement
In cell experiments, pal-KTTKS-enriched cellulose composites supported cell adhesion.
In plain wordsIn cells, pal-KTTKS-enriched cellulose composites supported attachment.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCell adhesion
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The developed composites supported cell adhesion and proliferation and showed good biocompatibility.
1 context sentence(design, population, supporting numbers)
Summary · context
The carboxylated cellulose was developed through the in situ synthesis method and further reinforced by incorporating pal-KTTKS to stimulate collagen synthesis and improve wound healing.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3885035301
11LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Safety outcome
In cell experiments, pal-KTTKS-enriched cellulose composites showed good biocompatibility.
In plain wordsIn cells, pal-KTTKS-enriched cellulose composites showed good compatibility.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
Not applicableComposite biocompatibility
Study
n: not reported in source
Outcome group
Adverse events · Skin and wound
Source sentences
Summary
The developed composites supported cell adhesion and proliferation and showed good biocompatibility.
1 context sentence(design, population, supporting numbers)
Summary · context
The carboxylated cellulose was developed through the in situ synthesis method and further reinforced by incorporating pal-KTTKS to stimulate collagen synthesis and improve wound healing.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3885035302
12LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Activity measurement
In cell experiments, pal-KTTKS-enriched cellulose composites supported cell proliferation.
In plain wordsIn cells, pal-KTTKS-enriched cellulose composites supported cell growth.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseCell proliferation
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The developed composites supported cell adhesion and proliferation and showed good biocompatibility.
1 context sentence(design, population, supporting numbers)
Summary · context
The carboxylated cellulose was developed through the in situ synthesis method and further reinforced by incorporating pal-KTTKS to stimulate collagen synthesis and improve wound healing.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3885035312

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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