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Study · Not a test of the peptide alone · 2024

2 results

Characterization of oxytocin and vasopressin receptors in the Southern giant pouched rat and comparison to other rodents.

Freeman AR, Arenas S, Lee DN, Singh B, Ophir AG

Frontiers in endocrinology13 May 2024Cited by 2 (Europe PMC)

PMID38803478 (opens in a new tab)PMCIDPMC11128605 (opens in a new tab)DOI10.3389/fendo.2024.1390203 (opens in a new tab)PepBankPUB-38803478
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Summary

Vasopressin and oxytocin are well known and evolutionarily ancient modulators of social behavior. The distribution and relative densities of vasopressin and oxytocin receptors are known to modulate the sensitivity to these signaling molecules. Comparative work is needed to determine which neural networks have been conserved and modified over evolutionary time, and which social behaviors are commonly modulated by nonapeptide signaling. To this end, we used receptor autoradiography to determine the distribution of vasopressin 1a and oxytocin receptors in the Southern giant pouched rat (Cricetomys ansorgei) brain, and to assess the relative densities of these receptors in specific brain regions. We then compared the relative receptor pattern to 23 other species of rodents using a multivariate ANOVA. Pouched rat receptor patterns were strikingly similar to hamsters and voles overall, despite the variation in social organization among species. Uniquely, the pouched rat had dense vasopressin 1a receptor binding in the caudate-putamen (i.e., striatum), an area that might impact affiliative behavior in this species. In contrast, the pouched rat had relatively little oxytocin receptor binding in much of the anterior forebrain. Notably, however, oxytocin receptor binding demonstrated extremely dense binding in the bed nucleus of the stria terminalis, which is associated with the modulation of several social behaviors and a central hub of the social decision-making network. Examination of the nonapeptide system has the potential to reveal insights into species-specific behaviors and general themes in the modulation of social behavior.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the Southern giant pouched rat brain, oxytocin receptor binding was relatively low in much of the anterior forebrain.

    In plain wordsIn pouched rats, oxytocin receptors were sparse across much of the front of the brain.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor binding in anterior forebrain
    Study

    Southern giant pouched ratn: not reported in source

    Brain receptor autoradiography
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In contrast, the pouched rat had relatively little oxytocin receptor binding in much of the anterior forebrain.
    1 context sentence
    Summary · context
    To this end, we used receptor autoradiography to determine the distribution of vasopressin 1a and oxytocin receptors in the Southern giant pouched rat (Cricetomys ansorgei) brain, and to assess the relative densities of these receptors in specific brain regions.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the Southern giant pouched rat brain, oxytocin receptor binding was extremely dense in the bed nucleus of the stria terminalis.

    In plain wordsIn pouched rats, oxytocin receptors were very dense in one brain area linked to social behavior.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor binding in bed nucleus of the stria terminalis
    Study

    Southern giant pouched ratn: not reported in source

    Brain receptor autoradiography
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    oxytocin receptor binding demonstrated extremely dense binding in the bed nucleus of the stria terminalis
    1 context sentence
    Summary · context
    To this end, we used receptor autoradiography to determine the distribution of vasopressin 1a and oxytocin receptors in the Southern giant pouched rat (Cricetomys ansorgei) brain, and to assess the relative densities of these receptors in specific brain regions.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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