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Study · In vitro (cells) · pseudomonas aeruginosa · 2024

1 result

Synthesis of the Antimicrobial Peptide Murepavadin Using Novel Coupling Agents.

García-Gros J, Cajal Y, Marqués AM, Rabanal F

Biomolecules27 Apr 2024Cited by 6 (Europe PMC)

PMID38785933 (opens in a new tab)PMCIDPMC11117477 (opens in a new tab)DOI10.3390/biom14050526 (opens in a new tab)PepBankPUB-38785933
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Summary

The problem of antimicrobial resistance is becoming a daunting challenge for human society and healthcare systems around the world. Hence, there is a constant need to develop new antibiotics to fight resistant bacteria, among other important social and economic measures. In this regard, murepavadin is a cyclic antibacterial peptide in development. The synthesis of murepavadin was undertaken in order to optimize the preparative protocol and scale-up, in particular, the use of new activation reagents. In our hands, classical approaches using carbodiimide/hydroxybenzotriazole rendered low yields. The use of novel carbodiimide and reagents based on OxymaPure® and Oxy-B is discussed together with the proper use of chromatographic conditions for the adequate characterization of peptide crudes. Higher yields and purities were obtained. Finally, the antimicrobial activity of different synthetic batches was tested in three Pseudomonas aeruginosa strains, including highly resistant ones. All murepavadin batches yielded the same highly active MIC values and proved that the chiral integrity of the molecule was preserved throughout the whole synthetic procedure.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In three Pseudomonas aeruginosa strains, all synthetic murepavadin batches yielded the same highly active MIC values.

    In plain wordsIn lab tests, all murepavadin batches had the same highly active MIC values against three bacterial strains.

    Peptide
    Murepavadin
    Outcome
    Not applicableAntimicrobial activity of synthetic batches
    Study

    Pseudomonas aeruginosan: not reported in source

    Three bacterial strains
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All murepavadin batches yielded the same highly active MIC values
    1 context sentence
    Summary · context
    Finally, the antimicrobial activity of different synthetic batches was tested in three Pseudomonas aeruginosa strains, including highly resistant ones.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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