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Study · Animal study (in vivo) · mouse · 2024

4 results

Integrated ribosome and proteome analyses reveal insights into sevoflurane-induced long-term social behavior and cognitive dysfunctions through ADNP inhibition in neonatal mice.

Liang LR, Liu B, Cao SH, Zhao YY, Zeng T, Zhai MT, Fan Z, He DY, Ma SX, Shi XT, Zhang Y, Zhang H

Zoological research1 May 2024Cited by 11 (Europe PMC)

PMID38766748 (opens in a new tab)PMCIDPMC11188609 (opens in a new tab)DOI10.24272/j.issn.2095-8137.2023.315 (opens in a new tab)PepBankPUB-38766748
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to sevoflurane during development, davunetide significantly ameliorated synaptic defects.

    In plain wordsIn mice exposed to sevoflurane during development, davunetide significantly reduced synaptic defects.

    Peptide
    Davunetide
    Outcome
    DecreaseSynaptic defects
    Study

    mousen: not reported in source

    neonatal sevoflurane exposure
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, davunetide significantly ameliorated the synaptic defects, social behavior deficits, and cognitive impairments induced by sevoflurane.
    1 context sentence
    Summary · context
    In this study, ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to sevoflurane during development, davunetide significantly ameliorated social behavior deficits.

    In plain wordsIn mice exposed to sevoflurane during development, davunetide significantly reduced social behavior deficits.

    Peptide
    Davunetide
    Outcome
    DecreaseSocial behavior deficits
    Study

    mousen: not reported in source

    neonatal sevoflurane exposure
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, davunetide significantly ameliorated the synaptic defects, social behavior deficits, and cognitive impairments induced by sevoflurane.
    1 context sentence
    Summary · context
    In this study, ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to sevoflurane during development, davunetide significantly ameliorated cognitive impairments.

    In plain wordsIn mice exposed to sevoflurane during development, davunetide significantly reduced cognitive impairments.

    Peptide
    Davunetide
    Outcome
    DecreaseCognitive impairments
    Study

    mousen: not reported in source

    neonatal sevoflurane exposure
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, davunetide significantly ameliorated the synaptic defects, social behavior deficits, and cognitive impairments induced by sevoflurane.
    1 context sentence
    Summary · context
    In this study, ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice exposed to sevoflurane during development, davunetide restored suppressed Wnt signaling.

    In plain wordsIn mice exposed to sevoflurane during development, davunetide restored suppressed Wnt signaling.

    Peptide
    Davunetide
    Outcome
    IncreaseWnt signaling
    Study

    mousen: not reported in source

    neonatal sevoflurane exposure
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Suppression of Wnt signaling was restored in the davunetide-treated group.
    1 context sentence
    Summary · context
    In this study, ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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