Skip to content

Study · Randomized controlled trial · n = 78 · 2024

5 results

Oxytocin-Augmented Modular-Based Group Intervention for Loneliness: A Proof-Of-Concept Randomized Controlled Trial.

Berger R, Hurlemann R, Shamay-Tsoory S, Kanterman A, Brauser M, Gorni J, Luhmann M, Schramm E, Schultz J, Philipsen A, Lieberz J, Scheele D

Psychotherapy and psychosomatics16 May 2024Cited by 9 (Europe PMC)

PMID38754399 (opens in a new tab)DOI10.1159/000538752 (opens in a new tab)PepBankPUB-38754399
Source linkPubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with high trait-like loneliness, intranasal oxytocin as an adjunct to group intervention had no significant effect on trait-like loneliness versus placebo.

    In plain wordsIn lonely adults in group therapy, oxytocin spray did not reduce lasting loneliness more than placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeTrait-like loneliness
    Study

    n = 78

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 5 weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    OT had no significant effect on trait-like loneliness, quality of life, or perceived stress.
    2 context sentences
    Summary · context
    Seventy-eight healthy HL adults (56 women) received five weekly group psychotherapy sessions.
    Summary · context
    HL participants received OT or placebo before the intervention sessions.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with high trait-like loneliness, intranasal oxytocin had no significant effect on quality of life versus placebo.

    In plain wordsIn lonely adults in group therapy, oxytocin spray did not change quality of life more than placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeQuality of life (WHO-5)
    Study

    n = 78

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Quality of life · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 5 weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    OT had no significant effect on trait-like loneliness, quality of life, or perceived stress.
    2 context sentences
    Summary · context
    Seventy-eight healthy HL adults (56 women) received five weekly group psychotherapy sessions.
    Summary · context
    HL participants received OT or placebo before the intervention sessions.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with high trait-like loneliness, intranasal oxytocin had no significant effect on perceived stress versus placebo.

    In plain wordsIn lonely adults in group therapy, oxytocin spray did not change perceived stress more than placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changePerceived stress (PSS-10)
    Study

    n = 78

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 5 weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    OT had no significant effect on trait-like loneliness, quality of life, or perceived stress.
    2 context sentences
    Summary · context
    Seventy-eight healthy HL adults (56 women) received five weekly group psychotherapy sessions.
    Summary · context
    HL participants received OT or placebo before the intervention sessions.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In adults with high trait-like loneliness, oxytocin significantly facilitated the decrease in state loneliness within sessions compared with placebo.

    In plain wordsIn lonely adults in group therapy, oxytocin spray helped loneliness drop during sessions more than placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseState loneliness within sessions
    Study

    n = 78

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 5 weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    compared to placebo, OT significantly facilitated the decrease in state loneliness within sessions
    2 context sentences
    Summary · context
    Seventy-eight healthy HL adults (56 women) received five weekly group psychotherapy sessions.
    Summary · context
    HL participants received OT or placebo before the intervention sessions.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In adults with high trait-like loneliness, oxytocin significantly improved positive bonding between group members compared with placebo.

    In plain wordsIn lonely adults in group therapy, oxytocin spray improved bonding between group members more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreasePositive bonding between group members
    Study

    n = 78

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasal · 5 weekly sessionsAs given in this study (human).

    Source sentences

    Summary
    compared to placebo, OT significantly facilitated the decrease in state loneliness within sessions and significantly improved positive bonding between the group members.
    2 context sentences
    Summary · context
    Seventy-eight healthy HL adults (56 women) received five weekly group psychotherapy sessions.
    Summary · context
    HL participants received OT or placebo before the intervention sessions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.