Acute Combined Cerebrolysin and Nicotinamide Administration Promote Cognitive Recovery Through Neuronal Changes in the Hippocampus of Rats with Permanent Middle Cerebral Artery Occlusion.

Martínez-Torres NI, Cárdenas-Bedoya J, Torres-Mendoza BM

Neuroscience9 May 2024Cited by 6 (Europe PMC)

PMID38734304DOI10.1016/j.neuroscience.2024.05.006PepBankPUB-38734304

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with permanent middle cerebral artery occlusion, CBL reduced infarct size.
In plain wordsIn rats with stroke, CBL reduced infarct size.
Peptide
Cerebrolysin
Outcome
DecreaseInfarct size
Study
ratn = 9
Male Sprague-Dawley rats with permanent middle cerebral artery occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5 ml/kgAs given in this study (rat).
Source sentences
Summary
Our findings revealed that the administration of CBL or NAM induced infarct reduction, improved cognition, and increased BDNF levels.
2 context sentences(design, population, supporting numbers)
Summary · context
A permanent middle cerebral artery occlusion (pMCAO) was induced through electrocauterization of the middle cerebral artery, followed by the administration of CBL (2.5 ml/kg), NAM (500 mg/kg) or combined immediately after skin suture, as well as at 24, 48, and 72 h post-surgery.
Summary · context
Male Sprague-Dawley rats (n = 36) were divided into four groups: saline (pMCAO - Saline), CBL (pMCAO + CBL), NAM (pMCAO + NAM), and experimental (pMCAO + CBL-NAM) (n = 9 per group).
Report a problemFND-3873430401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with permanent middle cerebral artery occlusion, CBL improved cognition.
In plain wordsIn rats with stroke, CBL improved cognition.
Peptide
Cerebrolysin
Outcome
IncreaseCognition
Study
ratn = 9
Male Sprague-Dawley rats with permanent middle cerebral artery occlusion
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
2.5 ml/kgAs given in this study (rat).
Source sentences
Summary
Our findings revealed that the administration of CBL or NAM induced infarct reduction, improved cognition, and increased BDNF levels.
2 context sentences(design, population, supporting numbers)
Summary · context
A permanent middle cerebral artery occlusion (pMCAO) was induced through electrocauterization of the middle cerebral artery, followed by the administration of CBL (2.5 ml/kg), NAM (500 mg/kg) or combined immediately after skin suture, as well as at 24, 48, and 72 h post-surgery.
Summary · context
Male Sprague-Dawley rats (n = 36) were divided into four groups: saline (pMCAO - Saline), CBL (pMCAO + CBL), NAM (pMCAO + NAM), and experimental (pMCAO + CBL-NAM) (n = 9 per group).
Report a problemFND-3873430402
03AnimalAnimal study (in vivo)Mechanism
In rats with permanent middle cerebral artery occlusion, CBL increased BDNF levels.
In plain wordsIn rats with stroke, CBL increased BDNF levels.
Peptide
Cerebrolysin
Outcome
IncreaseBDNF levels
Study
ratn = 9
Male Sprague-Dawley rats with permanent middle cerebral artery occlusion
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
2.5 ml/kgAs given in this study (rat).
Source sentences
Summary
Our findings revealed that the administration of CBL or NAM induced infarct reduction, improved cognition, and increased BDNF levels.
2 context sentences(design, population, supporting numbers)
Summary · context
A permanent middle cerebral artery occlusion (pMCAO) was induced through electrocauterization of the middle cerebral artery, followed by the administration of CBL (2.5 ml/kg), NAM (500 mg/kg) or combined immediately after skin suture, as well as at 24, 48, and 72 h post-surgery.
Summary · context
Male Sprague-Dawley rats (n = 36) were divided into four groups: saline (pMCAO - Saline), CBL (pMCAO + CBL), NAM (pMCAO + NAM), and experimental (pMCAO + CBL-NAM) (n = 9 per group).
Report a problemFND-3873430403

Studies that did not test the peptide alone1

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In rats with stroke, combined CBL and NAM increased dendritic intersection in CA1 pyramidal neurons.
In plain wordsIn rats with stroke, combined CBL and NAM increased dendritic intersection in CA1 neurons.
Peptide
Cerebrolysin
Outcome
IncreaseDendritic intersection
Study
ratn = 9
Male Sprague-Dawley rats with permanent middle cerebral artery occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Moreover, a combination of CBL and NAM increased dendritic intersection in CA1 pyramidal neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
Male Sprague-Dawley rats (n = 36) were divided into four groups: saline (pMCAO - Saline), CBL (pMCAO + CBL), NAM (pMCAO + NAM), and experimental (pMCAO + CBL-NAM) (n = 9 per group).
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3873430404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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