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Study · Measured the body's own peptide · 2023

6 results

Endogenous oxytocin and human social interactions: A systematic review and meta-analysis.

Burenkova OV, Dolgorukova TA, An I, Kustova TA, Podturkin AA, Shurdova EM, Talantseva OI, Zhukova MA, Grigorenko EL

Psychological bulletin1 Sept 2023Cited by 11 (Europe PMC)

PMID38713749 (opens in a new tab)PMCIDPMC11077008 (opens in a new tab)DOI10.1037/bul0000402 (opens in a new tab)PepBankPUB-38713749
Source linkPubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelSystematic reviewOther

    In a meta-analysis, social interaction did not lead to the expected change in the body's own oxytocin in pre-post causal designs.

    In plain wordsIn a meta-analysis, social interaction did not raise the body's own oxytocin levels as expected in before-and-after studies.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin response to social interaction, pre-post designs
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Nervous system and cognition

    Source sentences

    Summary
    social interaction did not lead to an expected hormonal response in causal designs, either in a pre-post design (g = 0.079)
    1 context sentence
    Summary · context
    Sixty-three studies were included in the qualitative synthesis, and results from 51 studies were pooled in a meta-analysis (n = 3,741 participants).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelSystematic reviewOther

    In a meta-analysis, comparing conditions with and without social interaction showed no expected change in the body's own oxytocin.

    In plain wordsIn a meta-analysis, groups with and without social interaction did not differ in the body's own oxytocin as expected.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin response to social interaction, experimental conditions with and without interaction
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Nervous system and cognition

    Source sentences

    Summary
    social interaction did not lead to an expected hormonal response in causal designs, either in a pre-post design (g = 0.079) or when comparing experimental conditions with and without social interaction (g = 0.256)
    1 context sentence
    Summary · context
    Sixty-three studies were included in the qualitative synthesis, and results from 51 studies were pooled in a meta-analysis (n = 3,741 participants).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelSystematic reviewOther

    In correlational designs of a meta-analysis, the overall mean effect size of correlations between social interaction indicators and the body's own oxytocin concentrations was significantly different from zero.

    In plain wordsIn correlational studies, social interaction measures were linked to the body's own oxytocin levels in a meta-analysis.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation between social interaction indicators and oxytocin concentrations
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Nervous system and cognition

    Source sentences

    Summary
    However, in correlational designs, the overall mean effect size (ES) of the correlations between indicators of social interaction and OXT concentrations was significantly different from zero (z = 0.137).
    1 context sentence
    Summary · context
    Sixty-three studies were included in the qualitative synthesis, and results from 51 studies were pooled in a meta-analysis (n = 3,741 participants).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelSystematic reviewOther

    In a meta-analysis, studies of parent-child interactions showed a significantly higher than zero mean effect size between social interaction and the body's own oxytocin.

    In plain wordsIn studies of parent-child interaction, social interaction was linked to higher body's own oxytocin levels in a meta-analysis.

    Peptide
    Oxytocin
    Outcome
    IncreaseCorrelation in studies of parent-child interactions
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Nervous system and cognition

    Source sentences

    Summary
    studies involving either parent-child interactions, or the utilization of the enzyme-linked immunosorbent assay method for OXT analysis, or unrestricted eating, drinking, or exercise before biofluid collection showed significantly higher than zero mean ESs
    1 context sentence
    Summary · context
    Sixty-three studies were included in the qualitative synthesis, and results from 51 studies were pooled in a meta-analysis (n = 3,741 participants).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelSystematic reviewOther

    In a meta-analysis, studies that measured oxytocin by the enzyme-linked immunosorbent assay method showed a significantly higher than zero mean effect size.

    In plain wordsIn studies measuring natural oxytocin by ELISA, social interaction was linked to higher oxytocin levels in a meta-analysis.

    Peptide
    Oxytocin
    Outcome
    IncreaseCorrelation in studies using ELISA for oxytocin analysis
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Nervous system and cognition

    Source sentences

    Summary
    studies involving either parent-child interactions, or the utilization of the enzyme-linked immunosorbent assay method for OXT analysis, or unrestricted eating, drinking, or exercise before biofluid collection showed significantly higher than zero mean ESs
    1 context sentence
    Summary · context
    Sixty-three studies were included in the qualitative synthesis, and results from 51 studies were pooled in a meta-analysis (n = 3,741 participants).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelSystematic reviewOther

    In a meta-analysis, studies with unrestricted eating, drinking or exercise before biofluid collection showed a significantly higher than zero mean effect size.

    In plain wordsIn studies without limits on eating, drinking or exercise before sampling, social interaction was linked to higher natural oxytocin levels.

    Peptide
    Oxytocin
    Outcome
    IncreaseCorrelation in studies with unrestricted eating, drinking or exercise before sampling
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Nervous system and cognition

    Source sentences

    Summary
    studies involving either parent-child interactions, or the utilization of the enzyme-linked immunosorbent assay method for OXT analysis, or unrestricted eating, drinking, or exercise before biofluid collection showed significantly higher than zero mean ESs
    1 context sentence
    Summary · context
    Sixty-three studies were included in the qualitative synthesis, and results from 51 studies were pooled in a meta-analysis (n = 3,741 participants).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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