Efficacy of Polyethylene Glycol Electrolyte Powder Combined With Linaclotide for Colon Cleansing in Patients With Chronic Constipation Undergoing Colonoscopy: A Multicenter, Single-Blinded, Randomized Controlled Trial.

Wang L, Zhang Y, Li J, Ran Y, Wang X, Ma X, Yang Q, Wang F, Hu J, Zhuang K, Wang J, Quan X and 9 more

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Wang S, Meng R, Chen Y, Li X, Song Y, Han S, Hu H, Li L, Dai F

Clinical and translational gastroenterology1 Jun 2024Cited by 14 (Europe PMC)

PMID38713137PMCIDPMC11196075DOI10.14309/ctg.0000000000000708PepBankPUB-38713137

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanRandomized controlled trialEfficacy outcome
In patients with chronic constipation, adequate preparation occurred in 80.0% with 4L PEG plus one-day linaclotide versus 60.3% with 4L PEG (P < 0.001).
In plain wordsAdding one-day linaclotide to 4L PEG increased adequate bowel preparation compared with 4L PEG alone.
Peptide
Linaclotide
Outcome
IncreaseAdequate bowel preparation
Study
n: not reported in source
Comparator
4L PEG
Analysis
Primary
Outcome group
Bowel Preparation · Gastrointestinal
Studied dose
Dose not stated · 1 dayAs given in this study (human).
Measurements
Adequate preparation
80%
4L PEG plus one-day linaclotide
Adequate preparation
60.3%
4L PEG
Source sentences
Summary
The rates of adequate bowel preparation (80.0% vs 60.3%, P < 0.001; 84.4% vs 60.3%, P < 0.001) and the total Boston Bowel Preparation Scale (BBPS) scores (6.90 ± 1.28 vs 6.00 ± 1.61, P < 0.001; 7.03 ± 1.24 vs 6.00 ± 1.61, P < 0.01) in the 4L-PEG+1d-Lin group and the 3L-PEG+3d-Lin group were superior…
2 context sentences(design, population, supporting numbers)
Summary · context
This single-blinded, randomized, controlled, and multicenter study was conducted from July 2021 to December 2022 at 7 hospitals.
Summary · context
Patients with CC who underwent colonoscopies were enrolled and randomly assigned to 4 groups with split-PEG regimens: 4L-PEG group, 4L-PEG+1d-Lin group, 3L-PEG+1d-Lin group, and 3L-PEG+3d-Lin group.
Report a problemFND-3871313701
02HumanRandomized controlled trialSafety outcome
In patients with chronic constipation, mild adverse events occurred in 66.7% with 4L PEG plus one-day linaclotide versus 81.7% with 4L PEG (P = 0.008).
In plain wordsAdding one-day linaclotide to 4L PEG reduced mild adverse events compared with 4L PEG alone.
Peptide
Linaclotide
Outcome
DecreaseMild adverse events
Study
n: not reported in source
Comparator
4L PEG
Analysis
Secondary
Outcome group
Adverse events · Gastrointestinal
Studied dose
Dose not stated · 1 dayAs given in this study (human).
Measurements
Mild adverse events
66.7%
4L-PEG+1d-Lin
Mild adverse events
81.7%
4L-PEG
P value
0.008 NA
4L-PEG+1d-Lin versus 4L-PEG
Source sentences
Summary
Compared with the 4L-PEG group, the 4L-PEG+1d-Lin group (66.7% vs 81.7%, P = 0.008) and the 3L-PEG+3d-Lin group (75.0% vs 81.7%, P = 0.224) had a lower percentage of mild adverse events.
2 context sentences(design, population, supporting numbers)
Summary · context
This single-blinded, randomized, controlled, and multicenter study was conducted from July 2021 to December 2022 at 7 hospitals.
Summary · context
Patients with CC who underwent colonoscopies were enrolled and randomly assigned to 4 groups with split-PEG regimens: 4L-PEG group, 4L-PEG+1d-Lin group, 3L-PEG+1d-Lin group, and 3L-PEG+3d-Lin group.
Report a problemFND-3871313703
03HumanRandomized controlled trialEfficacy outcome
In patients with chronic constipation, BBPS scores were 6.90 ± 1.28 with 4L PEG plus one-day linaclotide versus 6.00 ± 1.61 with 4L PEG (P < 0.001).
In plain wordsAdding one-day linaclotide to 4L PEG increased bowel cleansing scores compared with 4L PEG alone.
Peptide
Linaclotide
Outcome
IncreaseTotal BBPS score
Study
n: not reported in source
Comparator
4L PEG
Outcome group
Bowel Preparation · Gastrointestinal
Studied dose
Dose not stated · 1 dayAs given in this study (human).
Measurements
Total BBPS score
6.9 score
4L-PEG+1d-Lin
Total BBPS score spread (±)
1.28 score
4L-PEG+1d-Lin
Total BBPS score
6 score
4L-PEG
Total BBPS score spread (±)
1.61 score
4L-PEG
P value
< 0.001 NA
between groups
Source sentences
Summary
The rates of adequate bowel preparation (80.0% vs 60.3%, P < 0.001; 84.4% vs 60.3%, P < 0.001) and the total Boston Bowel Preparation Scale (BBPS) scores (6.90 ± 1.28 vs 6.00 ± 1.61, P < 0.001; 7.03 ± 1.24 vs 6.00 ± 1.61, P < 0.01) in the 4L-PEG+1d-Lin group and the 3L-PEG+3d-Lin group were superior…
2 context sentences(design, population, supporting numbers)
Summary · context
This single-blinded, randomized, controlled, and multicenter study was conducted from July 2021 to December 2022 at 7 hospitals.
Summary · context
Patients with CC who underwent colonoscopies were enrolled and randomly assigned to 4 groups with split-PEG regimens: 4L-PEG group, 4L-PEG+1d-Lin group, 3L-PEG+1d-Lin group, and 3L-PEG+3d-Lin group.
Report a problemFND-3871313702

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownNot applicableNCT05137145

Effect and Safety of Polyethylene Glycol Combined With Linaclotide on Colon Cleansing for Patients With Chronic Constipation

Second Affiliated Hospital of Xi'an Jiaotong Universityn = 3001 Sept 2021 to est. 30 Apr 2022

Bowel Preparation

Trial page ClinicalTrials.govUpdated 30 Nov 2021

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:34 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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