In eighty adults with sepsis requiring mechanical ventilation, high-dose enteral vitamin D3 raised serum LL‑37 more than low-dose vitamin D3 by day 7.
In plain wordsIn ventilated patients with sepsis, high-dose vitamin D raised the body's own LL‑37 levels more than low-dose vitamin D.
- Peptide
- LL-37
- Outcome
- IncreaseChange in serum LL-37 level on day 7 (day 7 minus day 0)
- Study
n = 80
- Comparator
- Low-dose enteral vitamin D3 (5000 IU, Group II)
- Analysis
- Secondary
- Outcome group
- Immune response · Immune and inflammation
Source sentences
The (day 7-day 0) change in serum PCT and LL-37 levels and SOFA score were significantly different in Group I (P = .010, P < .001, and P < .001, respectively).
increased serum LL-37 levels
2 context sentences(design, population, supporting numbers)
Eighty adult patients with sepsis requiring MV with known vitamin D deficiency were randomly assigned to receive either an enteral 50 000 IU (Group I) or 5000 IU (Group II) vitamin D supplementation.
while the change in serum LL-37 levels on day 7, changes in sequential organ failure assessment (SOFA) score, and clinical pulmonary infection score on day 7, MV duration, and hospital length of stay (LOS) were the secondary outcomes
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.