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Study · Randomized controlled trial · n = 18 · 2024

6 results

Subcutaneous Oxytocin Injection Reduces Heat Pain: A Randomized-Controlled Trial.

Albinni B, Zimmerman M, Ross J, Ozdoyuran L, Alasha V, Schuster NM, Said E, Case L

The journal of pain18 Apr 2024Cited by 4 (Europe PMC)

PMID38642595 (opens in a new tab)PMCIDPMC11975415 (opens in a new tab)DOI10.1016/j.jpain.2024.104547 (opens in a new tab)PepBankPUB-38642595
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy adults, subcutaneous oxytocin reduced ratings of heat pain intensity versus saline placebo.

    In plain wordsIn healthy adults, an oxytocin injection under the skin lowered heat pain intensity ratings compared with saline.

    Peptide
    Oxytocin
    Outcome
    DecreaseHeat pain intensity
    Study

    n = 18

    Comparator
    Saline placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mcg/2 mL · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Subcutaneous OT significantly reduced ratings of heat pain intensity and unpleasantness (both P < .01)
    2 context sentences
    Summary · context
    We conducted a 2-session crossover study during which healthy adults received a subcutaneous injection of synthetic OT (4 mcg/2 mL) or saline placebo (isotonic saline 2 mL), in a randomized and double-blinded manner.
    Summary · context
    Eighteen participants completed full study procedures.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy adults, subcutaneous oxytocin reduced ratings of heat pain unpleasantness versus saline placebo.

    In plain wordsIn healthy adults, an oxytocin injection under the skin made heat pain feel less unpleasant than saline.

    Peptide
    Oxytocin
    Outcome
    DecreaseHeat pain unpleasantness
    Study

    n = 18

    Comparator
    Saline placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mcg/2 mL · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Subcutaneous OT significantly reduced ratings of heat pain intensity and unpleasantness (both P < .01)
    2 context sentences
    Summary · context
    We conducted a 2-session crossover study during which healthy adults received a subcutaneous injection of synthetic OT (4 mcg/2 mL) or saline placebo (isotonic saline 2 mL), in a randomized and double-blinded manner.
    Summary · context
    Eighteen participants completed full study procedures.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy adults, subcutaneous oxytocin did not alter mechanical pain versus saline placebo.

    In plain wordsIn healthy adults, an oxytocin injection under the skin did not change mechanical pain compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeMechanical pain
    Study

    n = 18

    Comparator
    Saline placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mcg/2 mL · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    but did not alter mechanical pain, pressure pain, or heat pain threshold (all P > .05)
    2 context sentences
    Summary · context
    We conducted a 2-session crossover study during which healthy adults received a subcutaneous injection of synthetic OT (4 mcg/2 mL) or saline placebo (isotonic saline 2 mL), in a randomized and double-blinded manner.
    Summary · context
    Eighteen participants completed full study procedures.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy adults, subcutaneous oxytocin did not alter pressure pain versus saline placebo.

    In plain wordsIn healthy adults, an oxytocin injection under the skin did not change pressure pain compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changePressure pain
    Study

    n = 18

    Comparator
    Saline placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mcg/2 mL · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    but did not alter mechanical pain, pressure pain, or heat pain threshold (all P > .05)
    2 context sentences
    Summary · context
    We conducted a 2-session crossover study during which healthy adults received a subcutaneous injection of synthetic OT (4 mcg/2 mL) or saline placebo (isotonic saline 2 mL), in a randomized and double-blinded manner.
    Summary · context
    Eighteen participants completed full study procedures.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In healthy adults, subcutaneous oxytocin did not alter heat pain threshold versus saline placebo.

    In plain wordsIn healthy adults, an oxytocin injection under the skin did not change the point where heat starts to hurt, compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeHeat pain threshold
    Study

    n = 18

    Comparator
    Saline placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mcg/2 mL · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    but did not alter mechanical pain, pressure pain, or heat pain threshold (all P > .05)
    2 context sentences
    Summary · context
    We conducted a 2-session crossover study during which healthy adults received a subcutaneous injection of synthetic OT (4 mcg/2 mL) or saline placebo (isotonic saline 2 mL), in a randomized and double-blinded manner.
    Summary · context
    Eighteen participants completed full study procedures.
  6. 06HumanRandomized controlled trialMechanism

    In healthy adults, changes in heat pain after subcutaneous oxytocin were observed only on the injected arm and not on the contralateral arm.

    In plain wordsIn healthy adults, the oxytocin injection reduced heat pain only on the injected arm, not the other arm.

    Peptide
    Oxytocin
    Outcome
    DecreaseHeat pain change on injected versus contralateral arm
    Study

    n = 18

    Comparator
    Saline placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    4 mcg/2 mL · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Changes in heat pain were observed only on the injected arm and not on the contralateral arm, confirming a localized mechanism.
    2 context sentences
    Summary · context
    We conducted a 2-session crossover study during which healthy adults received a subcutaneous injection of synthetic OT (4 mcg/2 mL) or saline placebo (isotonic saline 2 mL), in a randomized and double-blinded manner.
    Summary · context
    Eighteen participants completed full study procedures.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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