Social functioning predicts individual changes in EEG microstates following intranasal oxytocin administration: A double-blind, cross-over randomized clinical trial.

Tomescu MI, Van der Donck S, Perisanu EM, Berceanu AI, Alaerts K, Boets B, Carcea I

Psychophysiology9 Apr 2024Cited by 6 (Europe PMC)

PMID38594888DOI10.1111/psyp.14581PepBankPUB-38594888

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialMechanism
In young adult men, single-dose intranasal oxytocin increased the representation of attention and salience EEG microstates at group level.
In plain wordsIn young men, oxytocin spray increased resting brain activity patterns linked to attention and salience, compared with placebo.
Peptide
Oxytocin
Outcome
IncreaseAttention and salience EEG microstates
Study
n = 30
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · single doseAs given in this study (human).
Source sentences
Summary
We confirmed previous reports that, at the group level, IN-OXT increases the representation of the attention and salience microstates.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a double-blinded, randomized, placebo-controlled, cross-over design on 30 typically developing young adult men to investigate the dynamics of EEG microstates corresponding to activity in defined neural networks.
Report a problemFND-3859488801
02HumanRandomized controlled trialMechanism
In young adult men, intranasal oxytocin decreased the representation of microstates associated with the default mode network.
In plain wordsIn young men, oxytocin spray reduced resting brain activity patterns linked to the default mode network, compared with placebo.
Peptide
Oxytocin
Outcome
DecreaseDefault mode network EEG microstates
Study
n = 30
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · single doseAs given in this study (human).
Source sentences
Summary
Furthermore, we identified a decreased representation of microstates associated with the default mode network.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a double-blinded, randomized, placebo-controlled, cross-over design on 30 typically developing young adult men to investigate the dynamics of EEG microstates corresponding to activity in defined neural networks.
Report a problemFND-3859488802
03HumanRandomized controlled trialMechanism
The higher the social functioning, the more oxytocin increased the visual network microstate and suppressed a default mode network microstate.
In plain wordsIn young men with higher social functioning, oxytocin spray changed resting brain patterns more strongly, compared with placebo.
Peptide
Oxytocin
Outcome
MixedVisual and default mode microstate change by high social functioning
Study
n = 30
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · single doseAs given in this study (human).
Source sentences
Summary
Correlation analysis further revealed that the higher the social functioning, the more IN-OXT increased the appearance of the visual network-associated microstate, and suppressed the appearance of a default mode network-related microstate.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a double-blinded, randomized, placebo-controlled, cross-over design on 30 typically developing young adult men to investigate the dynamics of EEG microstates corresponding to activity in defined neural networks.
Report a problemFND-3859488803
04HumanRandomized controlled trialMechanism
The lower the social functioning, the more oxytocin increased the appearance of the salience microstate.
In plain wordsIn young men with lower social functioning, oxytocin spray raised a salience-related brain pattern more strongly, compared with placebo.
Peptide
Oxytocin
Outcome
MixedSalience microstate change by low social functioning
Study
n = 30
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
Dose not stated · intranasal · single doseAs given in this study (human).
Source sentences
Summary
The lower the social functioning, the more IN-OXT increases the appearance of the salience microstate.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a double-blinded, randomized, placebo-controlled, cross-over design on 30 typically developing young adult men to investigate the dynamics of EEG microstates corresponding to activity in defined neural networks.
Report a problemFND-3859488804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1/2NCT03096249

The Influence of Oxytocin on Socio-communicative Sensitivity

KU Leuvenn = 3121 Nov 2016 to 30 Jul 2017

Oxytocin

Trial page ClinicalTrials.govUpdated 22 Jul 2022

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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