Murepavadin promotes the killing efficacies of aminoglycoside antibiotics against Pseudomonas aeruginosa by enhancing membrane potential.

Wei X, Gao J, Zhou D, Xu C, Chen P, Chen S, Zhang Y, Liu X, Li G, Zhu G, Liu H, Li J and 8 more

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Geng B, Gao L, Cheng Z, Lamont IL, Pletzer D, Jin Y, Jin S, Wu W

Antimicrobial agents and chemotherapy12 Mar 2024Cited by 11 (Europe PMC)

PMID38470195PMCIDPMC10989017DOI10.1128/aac.01539-23PepBankPUB-38470195

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In bacteria, murepavadin enhanced respiration activity.
In plain wordsIn lab tests, murepavadin increased bacterial respiration.
Peptide
Murepavadin
Outcome
IncreaseBacterial respiration
Study
Pseudomonas aeruginosan: not reported in source
Pseudomonas aeruginosa cultures
Outcome group
Receptor activity and mechanism · Infection
Studied dose
Dose not stated
Source sentences
Summary
We further demonstrated that murepavadin enhances bacterial respiration activity and subsequent membrane potential, which promotes intracellular uptake of aminoglycoside antibiotics.
Report a problemFND-3847019503
02LabIn vitro (cells)Mechanism
In bacteria, murepavadin enhanced membrane potential following increased respiration.
In plain wordsIn lab tests, murepavadin increased bacterial membrane potential.
Peptide
Murepavadin
Outcome
IncreaseMembrane potential
Study
Pseudomonas aeruginosan: not reported in source
Pseudomonas aeruginosa cultures
Outcome group
Receptor activity and mechanism · Infection
Studied dose
Dose not stated
Source sentences
Summary
We further demonstrated that murepavadin enhances bacterial respiration activity and subsequent membrane potential, which promotes intracellular uptake of aminoglycoside antibiotics.
Report a problemFND-3847019504

Studies that did not test the peptide alone4

In this study, Murepavadin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Murepavadin.

03AnimalNot a test of Murepavadin aloneAnimal study (in vivo)Efficacy outcome
In a murine pneumonia model, murepavadin with amikacin displayed a synergistic bactericidal effect.
In plain wordsIn mice with pneumonia, murepavadin with amikacin showed synergistic bacterial killing.
Peptide
Murepavadin
Outcome
IncreaseCombination bactericidal synergy
Study
Mousen: not reported in source
Murine pneumonia
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
In addition, the murepavadin-amikacin combination displayed a synergistic bactericidal effect in a murine pneumonia model.
In this study, Murepavadin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Murepavadin.
Report a problemFND-3847019506
04LabNot a test of Murepavadin aloneIn vitro (cells)Activity measurement
In vitro, murepavadin with tobramycin enhanced bactericidal efficacy.
In plain wordsIn lab tests, murepavadin with tobramycin increased bacterial killing.
Peptide
Murepavadin
Outcome
IncreaseTobramycin bactericidal efficacy
Study
Pseudomonas aeruginosan: not reported in source
Pseudomonas aeruginosa cultures
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
Here, we found that murepavadin enhances the bactericidal efficacies of tobramycin and amikacin.
In this study, Murepavadin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Murepavadin.
Report a problemFND-3847019501
05LabNot a test of Murepavadin aloneIn vitro (cells)Activity measurement
In vitro, murepavadin with amikacin enhanced bactericidal efficacy.
In plain wordsIn lab tests, murepavadin with amikacin increased bacterial killing.
Peptide
Murepavadin
Outcome
IncreaseAmikacin bactericidal efficacy
Study
Pseudomonas aeruginosan: not reported in source
Pseudomonas aeruginosa cultures
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
Here, we found that murepavadin enhances the bactericidal efficacies of tobramycin and amikacin.
In this study, Murepavadin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Murepavadin.
Report a problemFND-3847019502
06LabNot a test of Murepavadin aloneIn vitro (cells)Mechanism
In bacteria, murepavadin-associated enhancement of membrane potential promoted intracellular aminoglycoside uptake.
In plain wordsIn lab tests, murepavadin-associated changes promoted antibiotic entry into bacteria.
Peptide
Murepavadin
Outcome
IncreaseAminoglycoside uptake
Study
Pseudomonas aeruginosan: not reported in source
Pseudomonas aeruginosa cultures
Outcome group
Receptor activity and mechanism · Infection
Source sentences
Summary
We further demonstrated that murepavadin enhances bacterial respiration activity and subsequent membrane potential, which promotes intracellular uptake of aminoglycoside antibiotics.
In this study, Murepavadin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Murepavadin.
Report a problemFND-3847019505

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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