Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats.

Ozturk Öztürk DA, Erden Y, Tekin S

Neuroscience letters8 Mar 2024Cited by 2 (Europe PMC)

PMID38462167DOI10.1016/j.neulet.2024.137722PepBankPUB-38462167

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In obese and non-obese male rats, 14 days of central MOTS‑c infusion increased hypothalamic GnRH mRNA expression.
In plain wordsIn obese and non-obese rats, MOTS‑c infused into the brain raised the gene activity of GnRH, a reproductive hormone.
Peptide
MOTS-c
Outcome
IncreaseHypothalamic GnRH mRNA expression
Study
ratn = 80
Diet-induced obese and non-obese male Wistar Albino rats
Comparator
Sham (solvent) and untreated control rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricular · 14 daysAs given in this study (rat).
Source sentences
Summary
MOTS-c infusion caused an increase in GnRH mRNA, protein expression levels and serum testosterone, LH and FSH levels in obese and non-obese rats (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In the study, 80 male Wistar-Albino rats were divided into two main groups, obese and non-obese (n = 40).
Summary · context
The lateral ventricles of the animals in the treatment groups were infused with 10 and 100 µM MOTS-c (solvent in Sham group) for 14 days.
Report a problemFND-3846216701
02AnimalAnimal study (in vivo)Efficacy outcome
In obese and non-obese male rats, central MOTS‑c infusion increased hypothalamic GnRH protein expression.
In plain wordsIn obese and non-obese rats, MOTS‑c infused into the brain raised GnRH protein levels.
Peptide
MOTS-c
Outcome
IncreaseHypothalamic GnRH protein expression
Study
ratn = 80
Diet-induced obese and non-obese male Wistar Albino rats
Comparator
Sham (solvent) and untreated control rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricular · 14 daysAs given in this study (rat).
Source sentences
Summary
MOTS-c infusion caused an increase in GnRH mRNA, protein expression levels and serum testosterone, LH and FSH levels in obese and non-obese rats (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In the study, 80 male Wistar-Albino rats were divided into two main groups, obese and non-obese (n = 40).
Summary · context
The lateral ventricles of the animals in the treatment groups were infused with 10 and 100 µM MOTS-c (solvent in Sham group) for 14 days.
Report a problemFND-3846216702
03AnimalAnimal study (in vivo)Efficacy outcome
In obese and non-obese male rats, central MOTS‑c infusion increased serum testosterone.
In plain wordsIn obese and non-obese rats, MOTS‑c infused into the brain raised blood testosterone.
Peptide
MOTS-c
Outcome
IncreaseSerum testosterone
Study
ratn = 80
Diet-induced obese and non-obese male Wistar Albino rats
Comparator
Sham (solvent) and untreated control rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricular · 14 daysAs given in this study (rat).
Source sentences
Summary
MOTS-c infusion caused an increase in GnRH mRNA, protein expression levels and serum testosterone, LH and FSH levels in obese and non-obese rats (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In the study, 80 male Wistar-Albino rats were divided into two main groups, obese and non-obese (n = 40).
Summary · context
The lateral ventricles of the animals in the treatment groups were infused with 10 and 100 µM MOTS-c (solvent in Sham group) for 14 days.
Report a problemFND-3846216703
04AnimalAnimal study (in vivo)Efficacy outcome
In obese and non-obese male rats, central MOTS‑c infusion increased serum luteinizing hormone.
In plain wordsIn obese and non-obese rats, MOTS‑c infused into the brain raised blood luteinizing hormone.
Peptide
MOTS-c
Outcome
IncreaseSerum LH
Study
ratn = 80
Diet-induced obese and non-obese male Wistar Albino rats
Comparator
Sham (solvent) and untreated control rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricular · 14 daysAs given in this study (rat).
Source sentences
Summary
MOTS-c infusion caused an increase in GnRH mRNA, protein expression levels and serum testosterone, LH and FSH levels in obese and non-obese rats (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In the study, 80 male Wistar-Albino rats were divided into two main groups, obese and non-obese (n = 40).
Summary · context
The lateral ventricles of the animals in the treatment groups were infused with 10 and 100 µM MOTS-c (solvent in Sham group) for 14 days.
Report a problemFND-3846216704
05AnimalAnimal study (in vivo)Efficacy outcome
In obese and non-obese male rats, central MOTS‑c infusion increased serum follicle stimulating hormone.
In plain wordsIn obese and non-obese rats, MOTS‑c infused into the brain raised blood follicle stimulating hormone.
Peptide
MOTS-c
Outcome
IncreaseSerum FSH
Study
ratn = 80
Diet-induced obese and non-obese male Wistar Albino rats
Comparator
Sham (solvent) and untreated control rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricular · 14 daysAs given in this study (rat).
Source sentences
Summary
MOTS-c infusion caused an increase in GnRH mRNA, protein expression levels and serum testosterone, LH and FSH levels in obese and non-obese rats (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In the study, 80 male Wistar-Albino rats were divided into two main groups, obese and non-obese (n = 40).
Summary · context
The lateral ventricles of the animals in the treatment groups were infused with 10 and 100 µM MOTS-c (solvent in Sham group) for 14 days.
Report a problemFND-3846216705
06AnimalAnimal study (in vivo)Efficacy outcome
MOTS‑c administration upregulated hormone levels more strongly in non-obese than in obese male rats.
In plain wordsIn rats, MOTS‑c raised hormone levels more in non-obese rats than in obese rats.
Peptide
MOTS-c
Outcome
IncreaseHormone response in non-obese versus obese rats
Study
ratn = 80
Diet-induced obese and non-obese male Wistar Albino rats
Comparator
MOTS-c effect in obese rats
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 and 100 µM · intracerebroventricular · 14 daysAs given in this study (rat).
Source sentences
Summary
MOTS-c administration more significantly upregulated hormone levels in non-obese rats (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In the study, 80 male Wistar-Albino rats were divided into two main groups, obese and non-obese (n = 40).
Summary · context
The lateral ventricles of the animals in the treatment groups were infused with 10 and 100 µM MOTS-c (solvent in Sham group) for 14 days.
Report a problemFND-3846216706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

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Journal Article

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