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Study · In vitro (cells) · 2024

6 results

Rigid-flexible nanocarriers loaded with active peptides for antioxidant and anti-inflammatory applications in skin.

Wang Y, Lin J, Yu Z, Cheng J, Cheng J, Cui W

Colloids and surfaces. B, Biointerfaces30 Jan 2024Cited by 5 (Europe PMC)

PMID38394858 (opens in a new tab)DOI10.1016/j.colsurfb.2024.113772 (opens in a new tab)PepBankPUB-38394858
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cellular experiments, the GHK‑Cu nanocarrier system regulated Nrf2, SIRT1 and PEG2/COX-2-related signaling pathways; the direction is not stated.

    In plain wordsIn cells, the carrier system changed signaling pathways linked to oxidative stress, but the abstract does not give the direction.

    Peptide
    GHK-Cu
    Outcome
    Direction not reportedNrf2, SIRT1 and PEG2/COX-2 signaling pathways
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    cellular experiments showed that this system mainly regulates Nrf2, SIRT1, and PEG2/COX-2-related signaling pathways
    1 context sentence
    Summary · context
    Hence, a novel peptide nanocarrier of copper peptide (GHK-Cu) encapsulation developed by liposome technology combined with the classical Chinese concept of rigidity and flexibility.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cellular experiments, the GHK‑Cu nanocarrier system counteracted cellular inflammation from oxidative damage.

    In plain wordsIn cells, the carrier system with copper peptide reduced inflammation caused by oxidative damage.

    Peptide
    GHK-Cu
    Outcome
    DecreaseCellular inflammation from oxidative damage
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, cellular experiments showed that this system mainly regulates Nrf2, SIRT1, and PEG2/COX-2-related signaling pathways, thus effectively counteracting cellular inflammation, senescence, and apoptosis from oxidative damage.
    1 context sentence
    Summary · context
    Hence, a novel peptide nanocarrier of copper peptide (GHK-Cu) encapsulation developed by liposome technology combined with the classical Chinese concept of rigidity and flexibility.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cellular experiments, the GHK‑Cu nanocarrier system counteracted cellular senescence from oxidative damage.

    In plain wordsIn cells, the carrier system with copper peptide reduced signs of cell ageing caused by oxidative damage.

    Peptide
    GHK-Cu
    Outcome
    DecreaseCellular senescence from oxidative damage
    Study

    n: not reported in source

    Outcome group
    Aging markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, cellular experiments showed that this system mainly regulates Nrf2, SIRT1, and PEG2/COX-2-related signaling pathways, thus effectively counteracting cellular inflammation, senescence, and apoptosis from oxidative damage.
    1 context sentence
    Summary · context
    Hence, a novel peptide nanocarrier of copper peptide (GHK-Cu) encapsulation developed by liposome technology combined with the classical Chinese concept of rigidity and flexibility.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cellular experiments, the GHK‑Cu nanocarrier system counteracted apoptosis from oxidative damage.

    In plain wordsIn cells, the carrier system with copper peptide reduced cell death caused by oxidative damage.

    Peptide
    GHK-Cu
    Outcome
    DecreaseApoptosis from oxidative damage
    Study

    n: not reported in source

    Outcome group
    Aging markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, cellular experiments showed that this system mainly regulates Nrf2, SIRT1, and PEG2/COX-2-related signaling pathways, thus effectively counteracting cellular inflammation, senescence, and apoptosis from oxidative damage.
    1 context sentence
    Summary · context
    Hence, a novel peptide nanocarrier of copper peptide (GHK-Cu) encapsulation developed by liposome technology combined with the classical Chinese concept of rigidity and flexibility.

Studies that did not test the peptide alone2

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 05LabNot a test of GHK-Cu aloneIn vitro (cell-free)Other

    In vitro, the rigid-flexible liposome complex significantly slowed the release of GHK‑Cu.

    In plain wordsIn lab tests, the carrier slowed the release of copper peptide.

    Peptide
    GHK-Cu
    Outcome
    DecreaseRelease of GHK-Cu from the nanocarrier
    Study

    n: not reported in source

    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    In vitro, this complex not only significantly retarded the release ability of copper peptides, but also enabled copper peptides to be effectively resistant to enzymatic degradation.
    1 context sentence
    Summary · context
    Hence, a novel peptide nanocarrier of copper peptide (GHK-Cu) encapsulation developed by liposome technology combined with the classical Chinese concept of rigidity and flexibility.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  2. 06LabNot a test of GHK-Cu aloneIn vitro (cell-free)Other

    In vitro, the liposome complex made GHK‑Cu effectively resistant to enzymatic degradation.

    In plain wordsIn lab tests, the carrier protected copper peptide from being broken down by enzymes.

    Peptide
    GHK-Cu
    Outcome
    DecreaseEnzymatic degradation of GHK-Cu
    Study

    n: not reported in source

    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    In vitro, this complex not only significantly retarded the release ability of copper peptides, but also enabled copper peptides to be effectively resistant to enzymatic degradation.
    1 context sentence
    Summary · context
    Hence, a novel peptide nanocarrier of copper peptide (GHK-Cu) encapsulation developed by liposome technology combined with the classical Chinese concept of rigidity and flexibility.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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