Cerebrolysin potentiates the antidepressant effect of lithium in a rat model of depression.

Abdelaty AO, Tharwat EK, Abdelrahman AI, Elgohary A, Elsaeed H, El-Feky AS, Ebrahim YM, Habib A, Abd El Latif H, Khadrawy YA, Aboul Ezz HS, Noor NA and 4 more

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Fahmy HM, Mohammed FF, Radwan NM, Ahmed NA

Journal of psychiatric research17 Feb 2024Cited by 3 (Europe PMC)

PMID38394763DOI10.1016/j.jpsychires.2024.02.029PepBankPUB-38394763

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In reserpine depression model rats, cerebrolysin alone alleviated most behavioral alterations.
In plain wordsIn rats with reserpine-induced depression, cerebrolysin alone alleviated most behavioral changes.
Peptide
Cerebrolysin
Outcome
Not applicableBehavioral alterations
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
Report a problemFND-3839476301
02AnimalAnimal study (in vivo)Mechanism
In reserpine depression model rats, cerebrolysin alone alleviated most oxidative stress alterations.
In plain wordsIn rats with reserpine-induced depression, cerebrolysin alone alleviated most oxidative stress changes.
Peptide
Cerebrolysin
Outcome
Not applicableOxidative stress alterations
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
Report a problemFND-3839476302
03AnimalAnimal study (in vivo)Mechanism
In reserpine depression model rats, cerebrolysin alone alleviated most acetylcholinesterase alterations in the cortex and hippocampus.
In plain wordsIn rats with reserpine-induced depression, cerebrolysin alone alleviated most acetylcholinesterase changes in the cortex and hippocampus.
Peptide
Cerebrolysin
Outcome
Not applicableAcetylcholinesterase alterations
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
Report a problemFND-3839476303
04AnimalAnimal study (in vivo)Mechanism
In reserpine depression model rats, cerebrolysin alone alleviated most monoamine alterations in the cortex and hippocampus.
In plain wordsIn rats with reserpine-induced depression, cerebrolysin alone alleviated most monoamine changes in the cortex and hippocampus.
Peptide
Cerebrolysin
Outcome
Not applicableMonoamine alterations
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
Report a problemFND-3839476304
05AnimalAnimal study (in vivo)Mechanism
In reserpine depression model rats, cerebrolysin alone improved BDNF alterations induced by reserpine.
In plain wordsIn rats with reserpine-induced depression, cerebrolysin alone improved BDNF changes caused by reserpine.
Peptide
Cerebrolysin
Outcome
Not applicableBDNF alterations
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
It also improved the alterations in brain-derived neurotrophic factor (BDNF) and histopathology induced by reserpine.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
Report a problemFND-3839476305
06AnimalAnimal study (in vivo)Efficacy outcome
In reserpine depression model rats, cerebrolysin alone improved histopathological alterations induced by reserpine.
In plain wordsIn rats with reserpine-induced depression, cerebrolysin alone improved tissue changes caused by reserpine.
Peptide
Cerebrolysin
Outcome
Not applicableHistopathological alterations
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
It also improved the alterations in brain-derived neurotrophic factor (BDNF) and histopathology induced by reserpine.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
Report a problemFND-3839476306

Studies that did not test the peptide alone6

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In reserpine depression model rats, lithium with cerebrolysin alleviated most behavioral alterations.
In plain wordsIn rats with reserpine-induced depression, lithium with cerebrolysin alleviated most behavioral changes.
Peptide
Cerebrolysin
Outcome
Not applicableBehavioral alterations with combination
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3839476307
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In reserpine depression model rats, lithium with cerebrolysin alleviated most oxidative stress alterations.
In plain wordsIn rats with reserpine-induced depression, lithium with cerebrolysin alleviated most oxidative stress changes.
Peptide
Cerebrolysin
Outcome
Not applicableOxidative stress alterations with combination
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3839476308
09AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In reserpine depression model rats, lithium with cerebrolysin alleviated most acetylcholinesterase alterations in the cortex and hippocampus.
In plain wordsIn rats with reserpine-induced depression, lithium with cerebrolysin alleviated most acetylcholinesterase changes in the cortex and hippocampus.
Peptide
Cerebrolysin
Outcome
Not applicableAcetylcholinesterase alterations with combination
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3839476309
10AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In reserpine depression model rats, lithium with cerebrolysin alleviated most monoamine alterations in the cortex and hippocampus.
In plain wordsIn rats with reserpine-induced depression, lithium with cerebrolysin alleviated most monoamine changes in the cortex and hippocampus.
Peptide
Cerebrolysin
Outcome
Not applicableMonoamine alterations with combination
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3839476310
11AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In reserpine depression model rats, lithium with cerebrolysin improved BDNF alterations induced by reserpine.
In plain wordsIn rats with reserpine-induced depression, lithium with cerebrolysin improved BDNF changes caused by reserpine.
Peptide
Cerebrolysin
Outcome
Not applicableBDNF alterations with combination
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
It also improved the alterations in brain-derived neurotrophic factor (BDNF) and histopathology induced by reserpine.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3839476311
12AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In reserpine depression model rats, lithium with cerebrolysin improved histopathological alterations induced by reserpine.
In plain wordsIn rats with reserpine-induced depression, lithium with cerebrolysin improved tissue changes caused by reserpine.
Peptide
Cerebrolysin
Outcome
Not applicableHistopathological alterations with combination
Study
ratn: not reported in source
Reserpine-induced depression model
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
It also improved the alterations in brain-derived neurotrophic factor (BDNF) and histopathology induced by reserpine.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with lithium, cerebrolysin, or their combination alleviated most of the changes in behavior, oxidative stress parameters, acetylcholinesterase and monoamines in the cortex and hippocampus of the reserpine-induced model of depression.
Summary · context
The model animals were further divided into rat model of depression, rat model treated with lithium, rat model treated with cerebrolysin and rat model treated with a combination of lithium and cerebrolysin.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3839476312

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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