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Study · Not a test of the peptide alone · 2024

4 results

Biodegradable Nanoflowers with Abaloparatide Spatiotemporal Management of Functional Alveolar Bone Regeneration.

Tan B, Wu Y, Wang R, Lee D, Li Y, Qian Z, Liao J

Nano letters13 Feb 2024Cited by 5 (Europe PMC)

PMID38350110 (opens in a new tab)DOI10.1021/acs.nanolett.3c04977 (opens in a new tab)PepBankPUB-38350110
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Abaloparatide (Tymlos).

  1. 01AnimalNot a test of Abaloparatide (Tymlos) aloneOther designMechanism

    In the alveolar regeneration model, abaloparatide-loaded bioactive nanoflowers initially released abaloparatide to recruit stem cells.

    In plain wordsIn the bone regeneration model, the abaloparatide nanoflower formulation released abaloparatide to recruit stem cells.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseStem cell recruitment
    Study

    n: not reported in source

    Post-extraction alveolar bone regeneration under orthodontic conditions
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    ABL was initially released to recruit stem cells, followed by sustained release of Ca2+ and PO43- for in situ interface mineralization, establishing an osteogenic "biomineralized environment".
    1 context sentence
    Summary · context
    In this study, we synthesized biodegradable bifunctional bioactive calcium phosphorus nanoflowers (NFs) loaded with abaloparatide (ABL), namely ABL@NFs, to achieve spatiotemporal management for alveolar bone regeneration.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  2. 02AnimalNot a test of Abaloparatide (Tymlos) aloneOther designEfficacy outcome

    In the alveolar regeneration model, abaloparatide-loaded bioactive nanoflowers restored morphologically and functionally active alveolar bone.

    In plain wordsIn the bone regeneration model, the abaloparatide nanoflower formulation restored active jaw bone.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseAlveolar bone restoration
    Study

    n: not reported in source

    Post-extraction alveolar bone regeneration under orthodontic conditions
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    ABL@NFs successfully restored morphologically and functionally active alveolar bone without affecting OTM.
    1 context sentence
    Summary · context
    In this study, we synthesized biodegradable bifunctional bioactive calcium phosphorus nanoflowers (NFs) loaded with abaloparatide (ABL), namely ABL@NFs, to achieve spatiotemporal management for alveolar bone regeneration.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  3. 03AnimalNot a test of Abaloparatide (Tymlos) aloneOther designEfficacy outcome

    In the alveolar regeneration model, abaloparatide-loaded bioactive nanoflowers did not affect orthodontic tooth movement.

    In plain wordsIn the bone regeneration model, the abaloparatide nanoflower formulation did not affect orthodontic tooth movement.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeOrthodontic tooth movement
    Study

    n: not reported in source

    Post-extraction alveolar bone regeneration under orthodontic conditions
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    ABL@NFs successfully restored morphologically and functionally active alveolar bone without affecting OTM.
    1 context sentence
    Summary · context
    In this study, we synthesized biodegradable bifunctional bioactive calcium phosphorus nanoflowers (NFs) loaded with abaloparatide (ABL), namely ABL@NFs, to achieve spatiotemporal management for alveolar bone regeneration.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  4. 04LabNot a test of Abaloparatide (Tymlos) aloneIn vitro (cell-free)Mechanism

    Abaloparatide-loaded nanoflowers released abaloparatide first, followed by sustained calcium and phosphate release for interface mineralization.

    In plain wordsIn lab tests, the nanoflowers released abaloparatide first, then calcium and phosphate for mineral formation.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    Not applicableSequential release and interface mineralization
    Study

    n: not reported in source

    Abaloparatide-loaded bioactive calcium phosphorus nanoflowers
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    ABL was initially released to recruit stem cells, followed by sustained release of Ca2+ and PO43- for in situ interface mineralization, establishing an osteogenic "biomineralized environment".
    1 context sentence
    Summary · context
    In this study, we synthesized biodegradable bifunctional bioactive calcium phosphorus nanoflowers (NFs) loaded with abaloparatide (ABL), namely ABL@NFs, to achieve spatiotemporal management for alveolar bone regeneration.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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