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Study · Animal study (in vivo) · mouse · 2024

4 results

Design and synthesis of nano-biomaterials based on graphene and local delivery of cerebrolysin into the injured spinal cord of mice, promising neural restoration.

Yari-Ilkhchi A, Mahkam M, Ebrahimi-Kalan A, Zangbar HS

Nanoscale advances8 Jan 2024Cited by 9 (Europe PMC)

PMID38298594 (opens in a new tab)PMCIDPMC10825937 (opens in a new tab)DOI10.1039/d3na00760j (opens in a new tab)PepBankPUB-38298594
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Summary

Spinal cord injury (SCI) is an incurable and catastrophic health issue with no clinical solution. As part of cascade reactions, the inflammatory process and fibrous glial scar production aggravate the amount of lesion through a secondary damage mechanism, encouraging scientists from other disciplines to investigate new paths for solving this problem. Graphene oxide (GO) and its derivatives are among the most promising biomedical and nerve tissue regeneration materials due to their remarkable chemical, mechanical, and electrical properties. This paper designs and introduces a new GO-based nanomaterial to minimize inflammation and stimulate neurite regrowth. To improve biocompatibility, biodegradability, and cell proliferation, GO plates were modified with polyethylene glycol (PEG) and Au nanoparticles as neuroprotective and antibacterial agents, respectively. Preliminary biological investigations on bone marrow derived mesenchymal stem cells (BM-MSCs) with various concentrations of a graphenic nanocarrier indicated a lack of cell toxicity and an enhancement in BM-MSC proliferation of about 10% after 48 hours. Therapeutic nanostructures were used in the T10 segment of a mouse SCI model. The pathological and immunohistochemical data revealed that refilling tissue cavities, decreasing degeneration, and establishing neuroregeneration resulted in a considerable improvement of hind limb motor function. Furthermore, compared to the nanocomposite mixture alone, the intraspinal delivery of cerebrolysin (CRL) had a more satisfying impact on nerve regrowth, cystic cavity, hemorrhage avoidance, and motor function enhancement. This study demonstrates the potential of graphenic nanomaterials for SCI treatment and neuroregeneration applications.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, cerebrolysin delivery with the nanocomposite improved nerve regrowth more than the nanocomposite alone.

    In plain wordsIn mice with spinal cord injury, cerebrolysin with the nanocomposite improved nerve regrowth more than the nanocomposite alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNerve regrowth versus nanocomposite alone
    Study

    mousen: not reported in source

    T10 spinal cord injury model
    Comparator
    Nanocomposite mixture alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraspinalAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, compared to the nanocomposite mixture alone, the intraspinal delivery of cerebrolysin (CRL) had a more satisfying impact on nerve regrowth, cystic cavity, hemorrhage avoidance, and motor function enhancement.
    1 context sentence
    Summary · context
    Therapeutic nanostructures were used in the T10 segment of a mouse SCI model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, cerebrolysin delivery with the nanocomposite had a better cystic cavity outcome than the nanocomposite alone.

    In plain wordsIn mice with spinal cord injury, cerebrolysin with the nanocomposite had a better cystic cavity outcome than the nanocomposite alone.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableCystic cavity versus nanocomposite alone
    Study

    mousen: not reported in source

    T10 spinal cord injury model
    Comparator
    Nanocomposite mixture alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraspinalAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, compared to the nanocomposite mixture alone, the intraspinal delivery of cerebrolysin (CRL) had a more satisfying impact on nerve regrowth, cystic cavity, hemorrhage avoidance, and motor function enhancement.
    1 context sentence
    Summary · context
    Therapeutic nanostructures were used in the T10 segment of a mouse SCI model.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, cerebrolysin delivery with the nanocomposite improved hemorrhage avoidance more than the nanocomposite alone.

    In plain wordsIn mice with spinal cord injury, cerebrolysin with the nanocomposite improved hemorrhage avoidance more than the nanocomposite alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseHemorrhage avoidance versus nanocomposite alone
    Study

    mousen: not reported in source

    T10 spinal cord injury model
    Comparator
    Nanocomposite mixture alone
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intraspinalAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, compared to the nanocomposite mixture alone, the intraspinal delivery of cerebrolysin (CRL) had a more satisfying impact on nerve regrowth, cystic cavity, hemorrhage avoidance, and motor function enhancement.
    1 context sentence
    Summary · context
    Therapeutic nanostructures were used in the T10 segment of a mouse SCI model.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, cerebrolysin delivery with the nanocomposite improved motor function more than the nanocomposite alone.

    In plain wordsIn mice with spinal cord injury, cerebrolysin with the nanocomposite improved motor function more than the nanocomposite alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMotor function versus nanocomposite alone
    Study

    mousen: not reported in source

    T10 spinal cord injury model
    Comparator
    Nanocomposite mixture alone
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · intraspinalAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, compared to the nanocomposite mixture alone, the intraspinal delivery of cerebrolysin (CRL) had a more satisfying impact on nerve regrowth, cystic cavity, hemorrhage avoidance, and motor function enhancement.
    1 context sentence
    Summary · context
    Therapeutic nanostructures were used in the T10 segment of a mouse SCI model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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