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Study · Not a test of the peptide alone · 2024

9 results

Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers.

Li D, Shangguan J, Yu F, Lin G, Pan H, Zhang M, Lin H, Chen B, Xu H, Hu S

ACS applied materials & interfaces30 Jan 2024Cited by 16 (Europe PMC)

PMID38289234 (opens in a new tab)DOI10.1021/acsami.3c15684 (opens in a new tab)PepBankPUB-38289234
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking KPV.

  1. 01AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, rectal PHE-EK hydrogel (KPV plus EGF) hindered body weight loss.

    In plain wordsIn rats with colitis, a gel containing KPV and growth factor reduced weight loss.

    Peptide
    KPV
    Outcome
    DecreaseBody weight loss
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Body weight · Gastrointestinal

    Source sentences

    Summary
    When PHE-EK as a biomimetic mucus was rectally administrated to colitis rats, it effectively hindered the body weight loss, reduced the disease activity index and improved the colonic shorting.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  2. 02AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, rectal PHE-EK hydrogel (KPV plus EGF) reduced the disease activity index.

    In plain wordsIn rats with colitis, a gel containing KPV and growth factor lowered the disease score.

    Peptide
    KPV
    Outcome
    DecreaseDisease activity index
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    When PHE-EK as a biomimetic mucus was rectally administrated to colitis rats, it effectively hindered the body weight loss, reduced the disease activity index and improved the colonic shorting.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  3. 03AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, rectal PHE-EK hydrogel (KPV plus EGF) improved colonic shortening.

    In plain wordsIn rats with colitis, a gel containing KPV and growth factor reduced colon shortening.

    Peptide
    KPV
    Outcome
    DecreaseColon shortening
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    When PHE-EK as a biomimetic mucus was rectally administrated to colitis rats, it effectively hindered the body weight loss, reduced the disease activity index and improved the colonic shorting.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  4. 04AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, PHE-EK hydrogel (KPV plus EGF) substantially inhibited colonic IL-1β expression.

    In plain wordsIn rats with colitis, a gel containing KPV and growth factor lowered the inflammatory signal IL-1β in the colon.

    Peptide
    KPV
    Outcome
    DecreaseIL-1β expression in colon
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    Moreover, the expression of pro-inflammatory cytokines (e.g., IL-1β, IL-6, and TNF-α) at the laminae propria or epitheliums of the colon for colitis rats was substantially inhibited by PHE-EK.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  5. 05AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, PHE-EK hydrogel (KPV plus EGF) substantially inhibited colonic IL-6 expression.

    In plain wordsIn rats with colitis, a gel containing KPV and growth factor lowered the inflammatory signal IL-6 in the colon.

    Peptide
    KPV
    Outcome
    DecreaseIL-6 expression in colon
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    Moreover, the expression of pro-inflammatory cytokines (e.g., IL-1β, IL-6, and TNF-α) at the laminae propria or epitheliums of the colon for colitis rats was substantially inhibited by PHE-EK.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  6. 06AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, PHE-EK hydrogel (KPV plus EGF) substantially inhibited colonic TNF-α expression.

    In plain wordsIn rats with colitis, a gel containing KPV and growth factor lowered the inflammatory signal TNF-α in the colon.

    Peptide
    KPV
    Outcome
    DecreaseTNF-α expression in colon
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Inflammation markers · Gastrointestinal

    Source sentences

    Summary
    Moreover, the expression of pro-inflammatory cytokines (e.g., IL-1β, IL-6, and TNF-α) at the laminae propria or epitheliums of the colon for colitis rats was substantially inhibited by PHE-EK.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  7. 07AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, the colonic epithelium was well rearranged after PHE-EK hydrogel (KPV plus EGF) treatment.

    In plain wordsIn rats with colitis, the colon lining looked better organised after treatment with a gel containing KPV and growth factor.

    Peptide
    KPV
    Outcome
    Not applicableColonic epithelium rearrangement
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    Besides, the colonic epitheliums were well rearranged, and the tight junction proteins (Zonula-1 and Claudin-5) between them were greatly upregulated after PHE-EK treatment.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  8. 08AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, PHE-EK hydrogel (KPV plus EGF) greatly upregulated the tight junction protein Zonula-1.

    In plain wordsIn rats with colitis, a gel containing KPV and growth factor raised a gut-barrier protein.

    Peptide
    KPV
    Outcome
    IncreaseZonula-1 tight junction protein
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    Besides, the colonic epitheliums were well rearranged, and the tight junction proteins (Zonula-1 and Claudin-5) between them were greatly upregulated after PHE-EK treatment.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

  9. 09AnimalNot a test of KPV aloneAnimal study (in vivo)Efficacy outcome

    In colitis rats, PHE-EK hydrogel (KPV plus EGF) greatly upregulated the tight junction protein Claudin-5.

    In plain wordsIn rats with colitis, a gel containing KPV and growth factor raised a second gut-barrier protein.

    Peptide
    KPV
    Outcome
    IncreaseClaudin-5 tight junction protein
    Study

    ratn: not reported in source

    Colitis rats
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    Besides, the colonic epitheliums were well rearranged, and the tight junction proteins (Zonula-1 and Claudin-5) between them were greatly upregulated after PHE-EK treatment.

    In this study, KPV was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking KPV.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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