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Study · Measured the body's own peptide · 2023

2 results

Differential Expression of Insulin Growth Factor 1 (IGF-1) Isoforms in Different Types of Endometriosis: Preliminary Results of a Single-Center Study.

Blontzos N, Mavrogianni D, Ntzeros K, Kathopoulis N, Moustogiannis A, Philippou A, Koutsilieris M, Protopapas A

Biomolecules20 Dec 2023Cited by 7 (Europe PMC)

PMID38275748 (opens in a new tab)PMCIDPMC10813029 (opens in a new tab)DOI10.3390/biom14010007 (opens in a new tab)PepBankPUB-38275748
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Summary

Endometriosis is a benign, estrogen-dependent gynecological condition with an uncertain exact pathogenetic mechanism. The aim of this study was to evaluate the potential differential expression of Insulin Growth Factor 1 (IGF-1) isoforms in deeply infiltrating endometriotic (DIE) lesions, in ovarian endometriomas, and in the eutopic endometrium of the same endometriosis patients and to compare their expression with that in the eutopic endometrium of women without endometriosis. A total of 39 patients were included: 28 with endometriosis, of whom 15 had endometriomas only, 7 had DIE nodules only, and 6 had both DIE and endometriomas, and 11 without endometriosis served as controls. We noticed a similar pattern of expression between IGF-1Ea and IGF-1Ec, which differed from that of the IGF-1Eb isoform, possibly implying differential biological actions of different isoforms in DIE subtypes. We observed a tendency of lower expression of IGF-1Ea and IGF-1Ec in endometriomas without DIE compared to endometriomas with concurrent DIE or in DIE nodules. In conclusion, differential expression of IGF-1 isoforms may indicate that DIE with its associated ovarian lesions and simple ovarian endometriosis should be considered as two forms of the disease developing under different molecular pathways.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In women with endometriosis, IGF-1Ec showed an expression pattern similar to IGF-1Ea and different from IGF-1Eb.

    In plain wordsIn women with endometriosis, the body's own IGF-1Ec followed the same pattern as IGF-1Ea and not that of IGF-1Eb.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableIGF-1Ec expression pattern compared with IGF-1Ea and IGF-1Eb
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    We noticed a similar pattern of expression between IGF-1Ea and IGF-1Ec, which differed from that of the IGF-1Eb isoform, possibly implying differential biological actions of different isoforms in DIE subtypes.
    1 context sentence
    Summary · context
    A total of 39 patients were included: 28 with endometriosis, of whom 15 had endometriomas only, 7 had DIE nodules only, and 6 had both DIE and endometriomas, and 11 without endometriosis served as controls.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In women with endometriosis, IGF-1Ec expression tended to be lower in endometriomas without DIE than in endometriomas with DIE or in DIE nodules.

    In plain wordsIn women with endometriosis, the body's own IGF-1Ec tended to be lower in simple endometriomas than in deeper lesions.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseIGF-1Ec expression in endometriomas without DIE
    Study

    n: not reported in source

    Comparator
    Endometriomas with concurrent DIE or DIE nodules
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    We observed a tendency of lower expression of IGF-1Ea and IGF-1Ec in endometriomas without DIE compared to endometriomas with concurrent DIE or in DIE nodules.
    1 context sentence
    Summary · context
    A total of 39 patients were included: 28 with endometriosis, of whom 15 had endometriomas only, 7 had DIE nodules only, and 6 had both DIE and endometriomas, and 11 without endometriosis served as controls.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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