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Study · In vitro (cells) · 2023

5 results

The Effect of Original Russian Neurotropic Drugs on Organic Anion Transporting Polypeptides OATP1B1 and OATP1B3.

Erokhina PD, Abalenikhina YV, Mylnikov PY, Petrov AV, Ganina SO, Konyakhin EA, Shchulkin AV, Yakusheva EN

Bulletin of experimental biology and medicine1 Dec 2023

PMID38198100 (opens in a new tab)DOI10.1007/s10517-024-05989-1 (opens in a new tab)PepBankPUB-38198100
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In HepG2 cells, omberacetam increased OATP1B1 content compared with control.

    In plain wordsIn cells, omberacetam increased OATP1B1 content compared with control.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseOATP1B1 content
    Study

    humann: not reported in source

    HepG2 cells
    Comparator
    Control
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    500 μMAs given in this study (human).

    Source sentences

    Summary
    It was shown that omberacetam (500 μM) increased the content of OATP1B1 and OATP1B3,
    1 context sentence
    Summary · context
    In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3.
  2. 02LabIn vitro (cells)Mechanism

    In HepG2 cells, omberacetam increased OATP1B3 content compared with control.

    In plain wordsIn cells, omberacetam increased OATP1B3 content compared with control.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseOATP1B3 content
    Study

    humann: not reported in source

    HepG2 cells
    Comparator
    Control
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    500 μMAs given in this study (human).

    Source sentences

    Summary
    It was shown that omberacetam (500 μM) increased the content of OATP1B1 and OATP1B3,
    1 context sentence
    Summary · context
    In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3.
  3. 03LabIn vitro (cells)Mechanism

    In HepG2 cells, omberacetam reduced the OATP1B1/OATP1B3 ratio.

    In plain wordsIn cells, omberacetam reduced the OATP1B1/OATP1B3 ratio.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseOATP1B1/OATP1B3 ratio
    Study

    humann: not reported in source

    HepG2 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    100-500 μMAs given in this study (human).

    Source sentences

    Summary
    The tested substances also reduced the OATP1B1/OATP1B3 ratio, as evidenced by a decrease in the penetration of atorvastatin, a substrate of the transporters, into HepG2 cells in the presence of omberacetam (100-500 μM), fabomotizole (500 μM), and EMHPS (10-500 μM).
    1 context sentence
    Summary · context
    In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3.
  4. 04LabIn vitro (cells)Activity measurement

    In HepG2 cells, omberacetam reduced atorvastatin penetration.

    In plain wordsIn cells, omberacetam reduced atorvastatin entry.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseAtorvastatin penetration
    Study

    humann: not reported in source

    HepG2 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    100-500 μMAs given in this study (human).

    Source sentences

    Summary
    The tested substances also reduced the OATP1B1/OATP1B3 ratio, as evidenced by a decrease in the penetration of atorvastatin, a substrate of the transporters, into HepG2 cells in the presence of omberacetam (100-500 μM), fabomotizole (500 μM), and EMHPS (10-500 μM).
    1 context sentence
    Summary · context
    In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3.

Studies that did not test the peptide alone1

In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Noopept (omberacetam).

  1. 05Computer modelNot a test of Noopept (omberacetam) aloneIn silicoOther

    A calculation found clinically insignificant OATP1B1/OATP1B3 effects for the tested substances, including omberacetam.

    In plain wordsComputer calculations suggested that transporter effects of the tested substances, including omberacetam, were clinically insignificant.

    Peptide
    Noopept (omberacetam)
    Outcome
    Not applicablePredicted clinical significance of transporter effects
    Study

    n: not reported in source

    FDA Cmax/IC50 clinical significance calculation
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Evaluation of clinical significance of the obtained results, according to the FDA approach based on the calculation of the Cmax/IC50 ratio, showed that the effect of the tested substances on OATP1B1/OATP1B3 is clinically insignificant.
    1 context sentence
    Summary · context
    In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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