Mechanochemical coupling of MGF mediates periodontal regeneration.

Zhao Y, Zhang S, Cheng B, Feng F, Zhu Y, Liu Y, Wang J, Zou D, Ma H, Xu F, Zhang M

Bioengineering & translational medicine7 Oct 2023Cited by 7 (Europe PMC)

PMID38193124PMCIDPMC10771565DOI10.1002/btm2.10603PepBankPUB-38193124

Summary

Clinical evidence shows that the mechanical stimulation obtained from occlusion could enhance periodontal ligament (PDL) remodeling. Mechano-growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration. In vivo study found that MGF produced from the PDL under occlusion force could strongly enhance PDL remodeling. In vitro experiments and mathematical modeling further confirmed the mechanical enhancement effect of MGF for PDLSC differentiation toward fibroblasts. A mechanochemical coupling effect of MGF mediated the enhancement of mechanical effect, which was modulated by Fyn-FAK kinases signaling and subsequent MAPK pathway. Finally, enhanced PDL regeneration under the mechanochemical coupling of MGF and occlusal force was verified in vivo. There exists an additive mechanical effect of MGF mediated by Fyn-FAK crosstalk and subsequent ERK1/2 and p38 phosphorylation, which could be developed as an MGF-centered adjuvant treatment to optimize PDL remodeling, especially for patients with weakened bite force or destroyed periodontium.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In vitro experiments and mathematical modeling confirmed that MGF enhanced the mechanical effect on periodontal ligament stem cell differentiation toward fibroblasts.
In plain wordsIn lab tests, MGF boosted the change of periodontal ligament stem cells into fibroblasts under mechanical force.
Peptide
MGF / PEG-MGF
Outcome
IncreasePDLSC differentiation toward fibroblasts
Study
n: not reported in source
Outcome group
Tendon and ligament healing · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In vitro experiments and mathematical modeling further confirmed the mechanical enhancement effect of MGF for PDLSC differentiation toward fibroblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
Mechano-growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration.
Show in the study text Report a problemFND-3819312402
02LabIn vitro (cells)Mechanism
A mechanochemical coupling effect of MGF mediated the enhancement of the mechanical effect, modulated by Fyn-FAK kinase signaling and the subsequent MAPK pathway.
In plain wordsIn lab tests, MGF and mechanical force worked together through Fyn-FAK and MAPK signaling.
Peptide
MGF / PEG-MGF
Outcome
Not applicableSignaling pathway of MGF mechanochemical coupling
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
A mechanochemical coupling effect of MGF mediated the enhancement of mechanical effect, which was modulated by Fyn-FAK kinases signaling and subsequent MAPK pathway.
1 context sentence(design, population, supporting numbers)
Summary · context
Mechano-growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration.
Show in the study text Report a problemFND-3819312403
03LabIn vitro (cells)Mechanism
An additive mechanical effect of MGF was mediated by Fyn-FAK crosstalk and subsequent ERK1/2 and p38 phosphorylation.
In plain wordsIn lab tests, MGF added to the effect of mechanical force through Fyn-FAK signaling and ERK1/2 and p38 activation.
Peptide
MGF / PEG-MGF
Outcome
IncreaseERK1/2 and p38 phosphorylation mediating the additive MGF effect
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
There exists an additive mechanical effect of MGF mediated by Fyn-FAK crosstalk and subsequent ERK1/2 and p38 phosphorylation
1 context sentence(design, population, supporting numbers)
Summary · context
Mechano-growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration.
Show in the study text Report a problemFND-3819312404

Studies that did not test the peptide alone2

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

04AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In vivo, MGF produced by the periodontal ligament under occlusion force strongly enhanced periodontal ligament remodeling.
In plain wordsIn animals, the body's own MGF made under bite force strongly improved remodeling of the tissue around teeth.
Peptide
MGF / PEG-MGF
Outcome
IncreasePDL remodeling with MGF produced under occlusion force
Study
n: not reported in source
Outcome group
Tendon and ligament healing · Musculoskeletal
Source sentences
Summary
In vivo study found that MGF produced from the PDL under occlusion force could strongly enhance PDL remodeling.
1 context sentence(design, population, supporting numbers)
Summary · context
Mechano-growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Show in the study text Report a problemFND-3819312401
05AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In vivo, periodontal ligament regeneration was enhanced under the mechanochemical coupling of MGF and occlusal force.
In plain wordsIn animals, MGF together with bite force improved regeneration of the tissue around teeth.
Peptide
MGF / PEG-MGF
Outcome
IncreasePDL regeneration with MGF plus occlusal force
Study
n: not reported in source
Outcome group
Tendon and ligament healing · Musculoskeletal
Source sentences
Summary
Finally, enhanced PDL regeneration under the mechanochemical coupling of MGF and occlusal force was verified in vivo.
1 context sentence(design, population, supporting numbers)
Summary · context
Mechano-growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Show in the study text Report a problemFND-3819312405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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