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Study · Animal study (in vivo) · mouse · 2024

10 results

Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

Kumagai H, Kim SJ, Miller B, Natsume T, Wan J, Kumagai ME, Ramirez R 2nd, Lee SH, Sato A, Mehta HH, Yen K, Cohen P

American journal of physiology. Endocrinology and metabolism3 Jan 2024Cited by 16 (Europe PMC)

PMID38170165 (opens in a new tab)PMCIDPMC11196098 (opens in a new tab)DOI10.1152/ajpendo.00285.2023 (opens in a new tab)PepBankPUB-38170165
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immobilized mice, MOTS‑c attenuated muscle loss: about 15% reduction of muscle mass with immobilization alone versus 5% with MOTS‑c.

    In plain wordsIn mice, MOTS‑c reduced the muscle loss caused by immobilization compared with immobilized mice given water.

    Peptide
    MOTS-c
    Outcome
    DecreaseImmobilization-induced loss of muscle mass
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Measurements

    Muscle mass reduction
    ≈ 15%
    Immobilization control
    Muscle mass reduction
    5%
    Immobilization plus MOTS-c

    Source sentences

    Summary
    Immobilization reduced ∼15% of muscle mass, whereas MOTS-c treatment attenuated muscle loss, with only a 5% reduction.
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, MOTS‑c normalized phospho-AKT expression levels.

    In plain wordsIn mice, MOTS‑c brought a muscle signalling marker (phospho-AKT) back to normal levels during immobilization.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedPhospho-AKT expression
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    MOTS-c treatment also normalized phospho-AKT, phospho-FOXO1, and phospho-FOXO3a expression levels
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, MOTS‑c normalized phospho-FOXO1 expression levels.

    In plain wordsIn mice, MOTS‑c brought a muscle signalling marker (phospho-FOXO1) back to normal levels during immobilization.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedPhospho-FOXO1 expression
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    MOTS-c treatment also normalized phospho-AKT, phospho-FOXO1, and phospho-FOXO3a expression levels
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, MOTS‑c normalized phospho-FOXO3a expression levels.

    In plain wordsIn mice, MOTS‑c brought a muscle signalling marker (phospho-FOXO3a) back to normal levels during immobilization.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedPhospho-FOXO3a expression
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    MOTS-c treatment also normalized phospho-AKT, phospho-FOXO1, and phospho-FOXO3a expression levels
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, MOTS‑c reduced circulating interleukin-1b (IL-1β).

    In plain wordsIn mice, MOTS‑c lowered the blood level of the inflammation marker IL-1β during immobilization.

    Peptide
    MOTS-c
    Outcome
    DecreaseCirculating IL-1β
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    reduced circulating inflammatory cytokines, such as interleukin-1b (IL-1β), interleukin-6 (IL-6), chemokine C-X-C motif ligand 1 (CXCL1), and monocyte chemoattractant protein 1 (MCP-1), in immobilized mice.
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, MOTS‑c reduced circulating interleukin-6 (IL-6).

    In plain wordsIn mice, MOTS‑c lowered the blood level of the inflammation marker IL-6 during immobilization.

    Peptide
    MOTS-c
    Outcome
    DecreaseCirculating IL-6
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    reduced circulating inflammatory cytokines, such as interleukin-1b (IL-1β), interleukin-6 (IL-6), chemokine C-X-C motif ligand 1 (CXCL1), and monocyte chemoattractant protein 1 (MCP-1), in immobilized mice.
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, MOTS‑c reduced circulating chemokine C-X-C motif ligand 1 (CXCL1).

    In plain wordsIn mice, MOTS‑c lowered the blood level of the inflammation marker CXCL1 during immobilization.

    Peptide
    MOTS-c
    Outcome
    DecreaseCirculating CXCL1
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    reduced circulating inflammatory cytokines, such as interleukin-1b (IL-1β), interleukin-6 (IL-6), chemokine C-X-C motif ligand 1 (CXCL1), and monocyte chemoattractant protein 1 (MCP-1), in immobilized mice.
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, MOTS‑c reduced circulating monocyte chemoattractant protein 1 (MCP-1).

    In plain wordsIn mice, MOTS‑c lowered the blood level of the inflammation marker MCP-1 during immobilization.

    Peptide
    MOTS-c
    Outcome
    DecreaseCirculating MCP-1
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    reduced circulating inflammatory cytokines, such as interleukin-1b (IL-1β), interleukin-6 (IL-6), chemokine C-X-C motif ligand 1 (CXCL1), and monocyte chemoattractant protein 1 (MCP-1), in immobilized mice.
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, MOTS‑c modified adipogenesis-modulating gene expression within the PPAR pathway in muscle.

    In plain wordsIn mice, MOTS‑c changed the activity of fat-formation genes in muscle during immobilization.

    Peptide
    MOTS-c
    Outcome
    Direction not reportedAdipogenesis-modulating gene expression in the PPAR pathway
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Immobilization control (sterilized water injection)
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    Unbiased RNA sequencing and its downstream analyses demonstrated that MOTS-c modified adipogenesis-modulating gene expression within the peroxisome proliferator-activated receptor (PPAR) pathway.
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In immobilized mice, muscle fatty acid levels were lower in the MOTS‑c-treated group than in casted control mice.

    In plain wordsIn mice, muscle fat levels were lower with MOTS‑c than in casted mice given water.

    Peptide
    MOTS-c
    Outcome
    DecreaseMuscle fatty acid levels
    Study

    mousen: not reported in source

    Immobilization-induced muscle atrophy (casting)
    Comparator
    Casted control mice
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    15 mg/kg/day · injection · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    Supporting this observation, muscle fatty acid levels were lower in the MOTS-c-treated group than in the casted control mice.
    1 context sentence
    Summary · context
    Male C57BL/6J mice (10 wk old) were randomly assigned to one of the three experimental groups: nonimmobilization control group (sterilized water injection), immobilization control group (sterilized water injection), and immobilization and MOTS-c-treated group (15 mg/kg/day MOTS-c injection).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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