Immune modulation via dendritic cells by the effect of Thymosin-alpha-1 on immune synapse in HCMV infection.

Espinar-Buitrago MS, Vazquez-Alejo E, Magro-Lopez E, Tarancon-Diez L, Leal M, Muñoz-Fernandez MA

International immunopharmacology31 Oct 2023Cited by 5 (Europe PMC)

PMID38149577DOI10.1016/j.intimp.2023.111103PepBankPUB-38149577

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In human dendritic cells in vitro, thymosin alpha‑1 increased CD40 expression.
In plain wordsIn cells in a dish, thymosin alpha‑1 raised CD40, a marker of immune cell activation, on dendritic cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseCD40 expression on dendritic cells
Study
humann: not reported in source
Dendritic cells and autologous T lymphocytes from PBMC, with and without HCMV
Comparator
Untreated cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The results showed that Tα1 increased CD40, CD80, TIM-3 and TNFα intracellular production while decreasing PDL-1 expression, particularly on plasmacytoid dendritic cells (pDCs).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to determine the in vitro immunomodulatory effect of Tα1 in human cytomegalovirus (HCMV) infection.
Summary · context
Dendritic cells (DCs) were isolated from peripheral blood mononuclear cells (PBMCs) by negative selection and cultured in the presence or absence of Tα1.
Report a problemFND-3814957701
02LabIn vitro (cells)Activity measurement
In human dendritic cells in vitro, thymosin alpha‑1 increased CD80 expression.
In plain wordsIn cells in a dish, thymosin alpha‑1 raised CD80, a marker of immune cell activation, on dendritic cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseCD80 expression on dendritic cells
Study
humann: not reported in source
Dendritic cells and autologous T lymphocytes from PBMC, with and without HCMV
Comparator
Untreated cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The results showed that Tα1 increased CD40, CD80, TIM-3 and TNFα intracellular production while decreasing PDL-1 expression, particularly on plasmacytoid dendritic cells (pDCs).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to determine the in vitro immunomodulatory effect of Tα1 in human cytomegalovirus (HCMV) infection.
Summary · context
Dendritic cells (DCs) were isolated from peripheral blood mononuclear cells (PBMCs) by negative selection and cultured in the presence or absence of Tα1.
Report a problemFND-3814957702
03LabIn vitro (cells)Activity measurement
In human dendritic cells in vitro, thymosin alpha‑1 increased TIM-3 expression.
In plain wordsIn cells in a dish, thymosin alpha‑1 raised TIM-3 on dendritic cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseTIM-3 expression on dendritic cells
Study
humann: not reported in source
Dendritic cells and autologous T lymphocytes from PBMC, with and without HCMV
Comparator
Untreated cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The results showed that Tα1 increased CD40, CD80, TIM-3 and TNFα intracellular production while decreasing PDL-1 expression, particularly on plasmacytoid dendritic cells (pDCs).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to determine the in vitro immunomodulatory effect of Tα1 in human cytomegalovirus (HCMV) infection.
Summary · context
Dendritic cells (DCs) were isolated from peripheral blood mononuclear cells (PBMCs) by negative selection and cultured in the presence or absence of Tα1.
Report a problemFND-3814957703
04LabIn vitro (cells)Activity measurement
In human dendritic cells in vitro, thymosin alpha‑1 increased intracellular TNFα production.
In plain wordsIn cells in a dish, thymosin alpha‑1 raised TNFα production inside dendritic cells.
Peptide
Thymosin alpha-1
Outcome
IncreaseIntracellular TNFα production in dendritic cells
Study
humann: not reported in source
Dendritic cells and autologous T lymphocytes from PBMC, with and without HCMV
Comparator
Untreated cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The results showed that Tα1 increased CD40, CD80, TIM-3 and TNFα intracellular production while decreasing PDL-1 expression, particularly on plasmacytoid dendritic cells (pDCs).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to determine the in vitro immunomodulatory effect of Tα1 in human cytomegalovirus (HCMV) infection.
Summary · context
Dendritic cells (DCs) were isolated from peripheral blood mononuclear cells (PBMCs) by negative selection and cultured in the presence or absence of Tα1.
Report a problemFND-3814957704
05LabIn vitro (cells)Activity measurement
In human dendritic cells in vitro, thymosin alpha‑1 decreased PDL-1 expression, particularly on plasmacytoid dendritic cells.
In plain wordsIn cells in a dish, thymosin alpha‑1 lowered PDL-1 on dendritic cells, mostly on plasmacytoid dendritic cells.
Peptide
Thymosin alpha-1
Outcome
DecreasePDL-1 expression on dendritic cells
Study
humann: not reported in source
Dendritic cells and autologous T lymphocytes from PBMC, with and without HCMV
Comparator
Untreated cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The results showed that Tα1 increased CD40, CD80, TIM-3 and TNFα intracellular production while decreasing PDL-1 expression, particularly on plasmacytoid dendritic cells (pDCs).
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to determine the in vitro immunomodulatory effect of Tα1 in human cytomegalovirus (HCMV) infection.
Summary · context
Dendritic cells (DCs) were isolated from peripheral blood mononuclear cells (PBMCs) by negative selection and cultured in the presence or absence of Tα1.
Report a problemFND-3814957705
06LabIn vitro (cells)Activity measurement
In co-cultures of T lymphocytes with thymosin alpha‑1-treated dendritic cells, TNFα, IFNγ and IL-2 production changed, with CD40/CD40-L upregulated and PDL-1/PD-1 downregulated.
In plain wordsIn cells in a dish, thymosin alpha‑1-treated dendritic cells changed T cell cytokine output, raising CD40/CD40-L and lowering PDL-1/PD-1.
Peptide
Thymosin alpha-1
Outcome
MixedTNFα, IFNγ and IL-2 production and CD40-L/PD-1 expression in T lymphocytes
Study
humann: not reported in source
Dendritic cells and autologous T lymphocytes from PBMC, with and without HCMV
Comparator
Untreated cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Therefore, Tα1 modulated the production of TNFα, IFNγ and IL-2 in both total and memory subsets of CD4+ and CD8+ TLs by upregulating CD40/CD40-L and downregulating PDL-1/PD-1 expression.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to determine the in vitro immunomodulatory effect of Tα1 in human cytomegalovirus (HCMV) infection.
Summary · context
Dendritic cells (DCs) were isolated from peripheral blood mononuclear cells (PBMCs) by negative selection and cultured in the presence or absence of Tα1.
Report a problemFND-3814957706
07LabIn vitro (cells)Activity measurement
In co-cultures with thymosin alpha‑1-treated dendritic cells, polyfunctionality of CD8+ T lymphocytes was enhanced.
In plain wordsIn cells in a dish, thymosin alpha‑1 treatment of dendritic cells improved how many functions CD8+ T cells performed.
Peptide
Thymosin alpha-1
Outcome
IncreasePolyfunctionality of CD8+ T lymphocytes
Study
humann: not reported in source
Dendritic cells and autologous T lymphocytes from PBMC, with and without HCMV
Comparator
Untreated cells
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
enhances the polyfunctionality of CD8+ TLs.
2 context sentences(design, population, supporting numbers)
Summary · context
The objective of this study was to determine the in vitro immunomodulatory effect of Tα1 in human cytomegalovirus (HCMV) infection.
Summary · context
Dendritic cells (DCs) were isolated from peripheral blood mononuclear cells (PBMCs) by negative selection and cultured in the presence or absence of Tα1.
Report a problemFND-3814957707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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