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Study · In vitro (cells) · 2023

2 results

Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors.

Silva-Reis SC, Correia XC, Costa-Almeida HF, Pires-Lima BL, Maronde D, Costa VM, García-Mera X, Cruz L, Brea J, Loza MI, Rodríguez-Borges JE, Sampaio-Dias IE

ACS medicinal chemistry letters14 Nov 2023Cited by 7 (Europe PMC)

PMID38116429 (opens in a new tab)PMCIDPMC10726482 (opens in a new tab)DOI10.1021/acsmedchemlett.3c00264 (opens in a new tab)PepBankPUB-38116429
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In receptor functional assays, MIF‑1 was active only at the highest tested concentration, with dopamine EC50 of 23.64 ± 6.73 nM.

    In plain wordsIn lab tests, MIF‑1 affected dopamine potency only at the highest concentration tested.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    Not applicableDopamine potency EC50
    Study

    n: not reported in source

    human dopamine D2 receptor functional assay
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    1 nMAs given in this study.

    Measurements

    Dopamine EC50
    23.64 nM
    MIF-1 at 1 nM

    Source sentences

    Summary
    In this assay, MIF-1 was only active at the highest concentration tested (EC50 = 23.64 ± 6.73 nM, at 1 nM).
  2. 02LabIn vitro (cells)Safety outcome

    In differentiated SH-SY5Y cells, MIF‑1 caused mild significant toxicity in the MTT reduction assay at 200 μM.

    In plain wordsIn cells, MIF‑1 caused mild toxicity at the tested concentration.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseMTT reduction cytotoxicity
    Study

    n: not reported in source

    differentiated SH-SY5Y cells
    Outcome group
    Adverse events · Pharmacology
    Studied dose
    200 μMAs given in this study.

    Measurements

    MTT assay result
    94.09%
    MIF-1 at 200 μM

    Source sentences

    Summary
    Cytotoxicity assays in differentiated SH-SY5Y cells showed that both MIF-1 (94.09 ± 5.75%, p 2 (89.73 ± 4.95%, p < 0.0001) exhibited mild but statistical significant toxicity (assessed through the MTT reduction assay) at 200 μM

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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