In cultured rat dorsal root ganglion neurons, Cerebrolysin attenuated the high-glucose reduction in cell-index area under the curve in a concentration-dependent manner.
In plain wordsIn lab tests with rat neurons, Cerebrolysin reduced the high-glucose loss of cell-index area compared with high glucose alone.
- Peptide
- Cerebrolysin
- Outcome
- IncreaseCell index area under the curve under high glucose
- Study
ratn: not reported in source
Cultured dorsal root ganglion neurons- Comparator
- High glucose without Cerebrolysin
- Analysis
- Primary
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 40 mg/mlAs given in this study (rat).
Source sentences
Co-treatment with Cerebrolysin (40 mg/ml) attenuated this high glucose-induced effect in a concentration-dependent manner.
4 context sentences(design, population, supporting numbers)
Exposure of DRG neurons to high glucose caused a rapid and persistent decrease in the mean AUC values compared to normoglycemic controls.
Cell index (derived from cell viability and neurite outgrowth) was recorded with Real-Time Cell Analyzer and was used as primary outcome measure.
DRG's were obtained from adult rats and the isolated neurons were seeded on E-Plate®'s equipped with gold microelectrodes, and incubated in culture media in a CO2 incubator at 37 C.
DRGs were exposed to high glucose (50 mM) in the absence and presence of different concentrations of Cerebrolysin ® (2-40 mg/ml).