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Study · Randomized controlled trial · n = 202 · 2023

2 results

The effectiveness of cerebrolysin, a multi-modal neurotrophic factor, for treatment of post-covid-19 persistent olfactory, gustatory and trigeminal chemosensory dysfunctions: a randomized clinical trial.

Hamed SA, Ahmed MAA

Expert review of clinical pharmacology1 Jul 2023Cited by 6 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with persistent post-COVID chemosensory disorders, complete recovery occurred in 61.5% with Cerebrolysin plus training, versus no recovery with training alone.

    In plain wordsIn patients with post-COVID sensory disorders, complete recovery occurred in 61.5% with Cerebrolysin plus training, versus none with training alone.

    Outcome
    IncreaseComplete chemosensory recovery
    Study

    n = 202

    Comparator
    Olfactory and gustatory trainings only
    Analysis
    Secondary
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/d, 5d/week · intramuscular · ≥ 8-24 weeksAs given in this study (human).

    Measurements

    Complete recovery
    61.5%
    Cerebrolysin
    Complete recovery
    80 patients
    Cerebrolysin

    Source sentences

    Summary
    Recovery was complete in 61.5% (n = 80) with cerebrolysin therapy and partial in 17% (n = 22). There was no recovery with trainings only.
    2 context sentences
    Summary · context
    Patients were randomized into group 1 (n = 150): received cerebrolysin [5 ml/d (IM), 5d/week] and practiced olfactory and gustatory trainings, and group 2 (n = 100): practiced olfactory and gustatory trainings only, for ≥ 8-24 weeks.
    Summary · context
    Analyses for secondary outcome were done on 202 patients (group 1 = 130; group 2 = 72).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with persistent post-COVID chemosensory disorders, partial recovery occurred in 17% with Cerebrolysin plus training, versus no recovery with training alone.

    In plain wordsIn patients with post-COVID sensory disorders, partial recovery occurred in 17% with Cerebrolysin plus training, versus none with training alone.

    Outcome
    IncreasePartial chemosensory recovery
    Study

    n = 202

    Comparator
    Olfactory and gustatory trainings only
    Analysis
    Secondary
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/d, 5d/week · intramuscular · ≥ 8-24 weeksAs given in this study (human).

    Measurements

    Partial recovery
    17%
    Cerebrolysin
    Partial recovery
    22 patients
    Cerebrolysin

    Source sentences

    Summary
    Recovery was complete in 61.5% (n = 80) with cerebrolysin therapy and partial in 17% (n = 22). There was no recovery with trainings only.
    2 context sentences
    Summary · context
    Patients were randomized into group 1 (n = 150): received cerebrolysin [5 ml/d (IM), 5d/week] and practiced olfactory and gustatory trainings, and group 2 (n = 100): practiced olfactory and gustatory trainings only, for ≥ 8-24 weeks.
    Summary · context
    Analyses for secondary outcome were done on 202 patients (group 1 = 130; group 2 = 72).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials2

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

2 trials · 2 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 4NCT06208540

Clinical Characteristics and Treatment of Anosmia and Ageusia Due to SARS-CoV2 Variants

Sherifa Ahmed Hamedn = 16030 Aug 2021 to 30 May 2024

Post-covid-19 Persistent Smell and Taste Disorders

CompletedPhase 3NCT04830943

Cerebrolycin for Treatment of Covid-related Anosmia and Ageusia

Assiut Universityn = 2501 Aug 2020 to 30 Oct 2022

Covid19 Related Anosmia and Aguesia

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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