Clomiphene Citrate and Enclomiphene Hydrochloride Exposure Is Associated With Interfrontal Suture Fusion in Zebrafish.

Franz-Odendaal TA, Bezuhly M

Plastic surgery (Oakville, Ont.)6 Dec 2021

PMID37915340PMCIDPMC10617459DOI10.1177/22925503211057526PepBankPUB-37915340

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Safety outcome
In zebrafish exposed at 5.5 mm SL, enclomiphene increased interfrontal suture fusion compared with controls.
In plain wordsIn zebrafish exposed at 5.5 mm SL, enclomiphene increased skull suture fusion compared with controls.
Peptide
Enclomiphene
Outcome
IncreaseInterfrontal suture fusion
Study
Danio rerion: not reported in source
Zebrafish calvarial development
Comparator
Controls
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · five daysAs given in this study (Danio rerio).
Source sentences
Summary
Treatments with CC or enclomiphene at 5.5 mm SL led to increased fusion of the interfrontal suture (p < .01) compared to controls.
1 context sentence(design, population, supporting numbers)
Summary · context
Zebrafish larvae were exposed to clomiphene citrate or its isomer enclomiphene for five days at key points during calvarial development. Larvae were then raised to adulthood in normal rearing water. Zebrafish were analyzed using whole-mount skeletal staining.
Report a problemFND-3791534001

Studies that did not test the peptide alone1

In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Enclomiphene.

02AnimalNot a test of Enclomiphene aloneAnimal study (in vivo)Safety outcome
In zebrafish, clomiphene or enclomiphene treatments had differential effects on survivability, growth and suture formation, without agent-specific details.
In plain wordsIn zebrafish, clomiphene or enclomiphene treatments affected survival, growth and skull sutures differently. The abstract did not separate these effects.
Peptide
Enclomiphene
Outcome
MixedSurvivability, growth and suture formation
Study
Danio rerion: not reported in source
Zebrafish calvarial development
Outcome group
Adverse events · Whole body
Source sentences
Summary
We observed differential effects on survivability, growth and suture formation depending on the treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Zebrafish larvae were exposed to clomiphene citrate or its isomer enclomiphene for five days at key points during calvarial development. Larvae were then raised to adulthood in normal rearing water. Zebrafish were analyzed using whole-mount skeletal staining.
In this study, Enclomiphene was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Enclomiphene.
Report a problemFND-3791534002

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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