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Study · Animal study (in vivo) · rat · 2024

3 results

Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia.

Jing X, Jia S, Teng M, Day BW, Afolayan AJ, Jarzembowski JA, Lin CW, Hessner MJ, Pritchard KA Jr, Naylor S, Konduri GG, Teng RJ

American journal of respiratory cell and molecular biology1 Feb 2024Cited by 32 (Europe PMC)

PMID37874230 (opens in a new tab)PMCIDPMC12042139 (opens in a new tab)DOI10.1165/rcmb.2023-0038oc (opens in a new tab)PepBankPUB-37874230
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rat pups with hyperoxia-induced BPD, Foxo4‑dri produced outcomes similar to TUDCA and KYC, which decreased cellular senescence.

    In plain wordsIn rat pups with lung injury, Foxo4‑dri had effects similar to two other drugs that reduced cell aging in the lungs.

    Peptide
    FOXO4-DRI
    Outcome
    DecreaseCellular senescence in BPD lungs
    Study

    ratn: not reported in source

    Sprague-Dawley rat pups with hyperoxia-induced BPD (95% oxygen, P1-P10)
    Outcome group
    Aging markers · Respiratory
    Studied dose
    Dose not stated · intraperitoneal · Doses at P4, P6, P8 and P10As given in this study (rat).

    Source sentences

    Summary
    Foxo4 dri administered at P4, P6, P8, and P10 led to outcomes similar to TUDCA and KYC.
    2 context sentences
    Summary · context
    Daily TUDCA or KYC, administered intraperitoneally, effectively decreased cellular senescence, improved alveolar complexity, and partially maintained the numbers of type 2 alveolar cells.
    Summary · context
    Sprague-Dawley rat pups exposed to 95% oxygen between Postnatal Day 1 (P1) and P10 were used as the BPD phenotype.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rat pups with hyperoxia-induced BPD, Foxo4‑dri produced outcomes similar to TUDCA and KYC, which improved alveolar complexity.

    In plain wordsIn rat pups with lung injury, Foxo4‑dri had effects similar to two other drugs that improved lung air sac structure.

    Peptide
    FOXO4-DRI
    Outcome
    IncreaseAlveolar complexity
    Study

    ratn: not reported in source

    Sprague-Dawley rat pups with hyperoxia-induced BPD (95% oxygen, P1-P10)
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · intraperitoneal · Doses at P4, P6, P8 and P10As given in this study (rat).

    Source sentences

    Summary
    Foxo4 dri administered at P4, P6, P8, and P10 led to outcomes similar to TUDCA and KYC.
    2 context sentences
    Summary · context
    Daily TUDCA or KYC, administered intraperitoneally, effectively decreased cellular senescence, improved alveolar complexity, and partially maintained the numbers of type 2 alveolar cells.
    Summary · context
    Sprague-Dawley rat pups exposed to 95% oxygen between Postnatal Day 1 (P1) and P10 were used as the BPD phenotype.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rat pups with hyperoxia-induced BPD, Foxo4‑dri produced outcomes similar to TUDCA and KYC, which partially maintained the numbers of type 2 alveolar cells.

    In plain wordsIn rat pups with lung injury, Foxo4‑dri had effects similar to two other drugs that partly kept the number of type 2 lung cells.

    Peptide
    FOXO4-DRI
    Outcome
    IncreaseType 2 alveolar cell numbers
    Study

    ratn: not reported in source

    Sprague-Dawley rat pups with hyperoxia-induced BPD (95% oxygen, P1-P10)
    Outcome group
    Aging markers · Respiratory
    Studied dose
    Dose not stated · intraperitoneal · Doses at P4, P6, P8 and P10As given in this study (rat).

    Source sentences

    Summary
    Foxo4 dri administered at P4, P6, P8, and P10 led to outcomes similar to TUDCA and KYC.
    2 context sentences
    Summary · context
    Daily TUDCA or KYC, administered intraperitoneally, effectively decreased cellular senescence, improved alveolar complexity, and partially maintained the numbers of type 2 alveolar cells.
    Summary · context
    Sprague-Dawley rat pups exposed to 95% oxygen between Postnatal Day 1 (P1) and P10 were used as the BPD phenotype.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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