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Study · Animal study (in vivo) · mouse · 2023

9 results

Comparative study in estrogen-depleted mice identifies skeletal and osteocyte transcriptomic responses to abaloparatide and teriparatide.

Lv Z, Zhang J, Liang S, Zhou C, Hu D, Brooks DJ, Bouxsein ML, Lanske B, Kostenuik P, Gori F, Baron R

JCI insight23 Oct 2023Cited by 9 (Europe PMC)

PMID37870958 (opens in a new tab)PMCIDPMC10619488 (opens in a new tab)DOI10.1172/jci.insight.161932 (opens in a new tab)PepBankPUB-37870958
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Summary

Osteocytes express parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptors and respond to the PTHrP analog abaloparatide (ABL) and to the PTH 1-34 fragment teriparatide (TPTD), which are used to treat osteoporosis. Several studies indicate overlapping but distinct skeletal responses to ABL or TPTD, but their effects on cortical bone may differ. Little is known about their differential effects on osteocytes. We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice. Administered 7 weeks after ovariectomy for 4 weeks at a dose of 40 μg/kg/d, TPTD and ABL had similar effects on trabecular bone, but ABL showed stronger effects in cortical bone. In cortical osteocytes, both treatments decreased lacunar area, reflecting altered peri-lacunar remodeling favoring matrix accumulation. Osteocyte RNA-Seq revealed that several genes and pathways were altered by ovariectomy and affected similarly by TPTD and ABL. Notwithstanding, several signaling pathways were uniquely regulated by ABL. Thus, in mice, TPTD and ABL induced a positive osteocyte peri-lacunar remodeling balance, but ABL induced stronger cortical responses and affected the osteocyte transcriptome differently. We concluded that ABL affected the cortical osteocyte transcriptome in a manner subtly different from TPTD, resulting in more beneficial remodeling/modeling changes and homeostasis of the cortex.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study9

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, abaloparatide and teriparatide had similar effects on trabecular bone.

    In plain wordsIn mice, abaloparatide and teriparatide had similar effects on trabecular bone.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    No significant changeTrabecular bone response
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Comparator
    Teriparatide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Administered 7 weeks after ovariectomy for 4 weeks at a dose of 40 μg/kg/d, TPTD and ABL had similar effects on trabecular bone, but ABL showed stronger effects in cortical bone.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, teriparatide and abaloparatide had similar effects on trabecular bone.

    In plain wordsIn mice, teriparatide and abaloparatide had similar effects on trabecular bone.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeTrabecular bone response
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Comparator
    Abaloparatide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Administered 7 weeks after ovariectomy for 4 weeks at a dose of 40 μg/kg/d, TPTD and ABL had similar effects on trabecular bone, but ABL showed stronger effects in cortical bone.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, abaloparatide had stronger cortical bone effects than teriparatide.

    In plain wordsIn mice, abaloparatide had stronger cortical bone effects than teriparatide.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseCortical bone response
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Comparator
    Teriparatide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Administered 7 weeks after ovariectomy for 4 weeks at a dose of 40 μg/kg/d, TPTD and ABL had similar effects on trabecular bone, but ABL showed stronger effects in cortical bone.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, teriparatide had weaker cortical bone effects than abaloparatide.

    In plain wordsIn mice, teriparatide had weaker cortical bone effects than abaloparatide.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseCortical bone response
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Comparator
    Abaloparatide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Administered 7 weeks after ovariectomy for 4 weeks at a dose of 40 μg/kg/d, TPTD and ABL had similar effects on trabecular bone, but ABL showed stronger effects in cortical bone.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, abaloparatide decreased cortical osteocyte lacunar area.

    In plain wordsIn mice, abaloparatide decreased cortical osteocyte lacunar area.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseOsteocyte lacunar area
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In cortical osteocytes, both treatments decreased lacunar area, reflecting altered peri-lacunar remodeling favoring matrix accumulation.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice, teriparatide decreased cortical osteocyte lacunar area.

    In plain wordsIn mice, teriparatide decreased cortical osteocyte lacunar area.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseOsteocyte lacunar area
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    40 μg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In cortical osteocytes, both treatments decreased lacunar area, reflecting altered peri-lacunar remodeling favoring matrix accumulation.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In osteocyte RNA-Seq analysis, teriparatide and abaloparatide similarly affected several genes and pathways altered by ovariectomy.

    In plain wordsIn mouse osteocytes, teriparatide and abaloparatide similarly affected several genes and pathways altered by ovariectomy.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    MixedTranscriptomic response
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    40 μg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Osteocyte RNA-Seq revealed that several genes and pathways were altered by ovariectomy and affected similarly by TPTD and ABL.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.

Studies that did not test the peptide alone2

In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Abaloparatide (Tymlos).

  1. 08Computer modelNot a test of Abaloparatide (Tymlos) aloneIn silicoMechanism

    In osteocyte RNA-Seq analysis, abaloparatide uniquely regulated several signaling pathways.

    In plain wordsComputer analysis of mouse osteocytes identified signaling pathways uniquely regulated by abaloparatide.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    MixedTranscriptomic pathway response
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Osteocyte RNA-Seq revealed that several genes and pathways were altered by ovariectomy and affected similarly by TPTD and ABL. Notwithstanding, several signaling pathways were uniquely regulated by ABL.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  2. 09Computer modelNot a test of Abaloparatide (Tymlos) aloneIn silicoMechanism

    In mouse osteocyte RNA-Seq analysis, abaloparatide and teriparatide similarly affected several genes and pathways altered by ovariectomy.

    In plain wordsComputer analysis of mouse osteocytes found similar gene and pathway responses to abaloparatide and teriparatide.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    MixedShared transcriptomic response
    Study

    mousen: not reported in source

    Sham-operated and ovariectomized mice
    Comparator
    Teriparatide
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Osteocyte RNA-Seq revealed that several genes and pathways were altered by ovariectomy and affected similarly by TPTD and ABL.
    1 context sentence
    Summary · context
    We compared cortical osteocyte and skeletal responses to ABL and TPTD in sham-operated and ovariectomized mice.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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