Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage.

Chulanova AA, Smakhtin MY, Bobyntsev II, Mishina ES, Artyushkova EB, Smakhtina AM

Bulletin of experimental biology and medicine1 Sept 2023

PMID37861903DOI10.1007/s10517-023-05929-5PepBankPUB-37861903

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymogen (oglufanide).

01AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In experimental hepatopathy, Thymogen and analogue treatments suppressed oxidative peroxidation.
In plain wordsIn an animal liver-injury model, Thymogen and analogue treatments reduced oxidative damage.
Peptide
Thymogen (oglufanide)
Outcome
DecreaseOxidative peroxidation
Study
n: not reported in source
Acute carbon tetrachloride hepatopathy
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Administration of peptides suppressed oxidative peroxidation and stimulated reparative regeneration of hepatocytes;
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3786190301
02AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In experimental hepatopathy, Thymogen and analogue treatments stimulated reparative hepatocyte regeneration.
In plain wordsIn an animal liver-injury model, Thymogen and analogue treatments increased liver-cell repair.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseHepatocyte reparative regeneration
Study
n: not reported in source
Acute carbon tetrachloride hepatopathy
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Administration of peptides suppressed oxidative peroxidation and stimulated reparative regeneration of hepatocytes;
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3786190302
03AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In experimental hepatopathy, Thymogen analogues produced more pronounced hepatotropic effects than Thymogen.
In plain wordsIn an animal liver-injury model, Thymogen analogues had stronger liver effects than Thymogen.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseComparative hepatotropic effect
Study
n: not reported in source
Acute carbon tetrachloride hepatopathy
Comparator
Thymogen
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Thymogen analogues produced more pronounced hepatotropic and antioxidant effects than Thymogen.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3786190303
04AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In experimental hepatopathy, Thymogen analogues produced more pronounced antioxidant effects than Thymogen.
In plain wordsIn an animal liver-injury model, Thymogen analogues had stronger antioxidant effects than Thymogen.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseComparative antioxidant effect
Study
n: not reported in source
Acute carbon tetrachloride hepatopathy
Comparator
Thymogen
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Thymogen analogues produced more pronounced hepatotropic and antioxidant effects than Thymogen.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3786190304
05AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In experimental hepatopathy, D-Ala addition enhanced Thymogen analogue effects on hepatocyte regeneration.
In plain wordsIn an animal liver-injury model, adding D-Ala strengthened liver-cell regeneration effects compared with Thymogen.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseRegeneration after D-Ala addition
Study
n: not reported in source
Acute carbon tetrachloride hepatopathy
Comparator
Thymogen
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Inclusion of D-Ala enhanced the effect of Thymogen on the processes of regeneration in hepatocytes and the antioxidant effect under conditions of acute carbon tetrachloride hepatopathy.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3786190305
06AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Efficacy outcome
In experimental hepatopathy, the C-terminal D-Ala thymogen analogue achieved the highest efficiency.
In plain wordsIn an animal liver-injury model, the C-terminal D-Ala thymogen analogue had the highest efficiency.
Peptide
Thymogen (oglufanide)
Outcome
IncreaseComparative analogue efficiency
Study
n: not reported in source
Acute carbon tetrachloride hepatopathy
Comparator
Other tested peptide structures
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
The highest efficiency was achieved when the amino acid was added to the C-end of the molecule.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy.
In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).
Report a problemFND-3786190306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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