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Study · Randomized controlled trial · n = 87 · 2024

2 results

The effect of Oxytocin administration on patient-therapist alliance congruence: Results from a randomized controlled trial.

Grossman-Giron A, Fisher H, Atzil-Slonim D, Maoz H, Nitzan U, Tzur Bitan D

Psychotherapy research : journal of the Society for Psychotherapy Research19 Oct 2023Cited by 4 (Europe PMC)

PMID37856680 (opens in a new tab)DOI10.1080/10503307.2023.2269300 (opens in a new tab)PepBankPUB-37856680
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In inpatients with mental disorders, intranasal oxytocin lowered the discrepancy between patient and therapist alliance ratings compared with placebo.

    In plain wordsIn inpatients with mental disorders, oxytocin made patient and therapist ratings of their working relationship agree more than placebo did.

    Peptide
    Oxytocin
    Outcome
    DecreasePatient-therapist working alliance discrepancy
    Study

    n = 87

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasal · four weeksAs given in this study (human).

    Source sentences

    Summary
    Oxytocin significantly moderated the level of agreement (b = -0.56, SE = 0.25, t = -2.30, p = 0.02), such that patients receiving OT demonstrated lower discrepancy (b = -0.73, p b = -1.30, p < 0.001).
    1 context sentence
    Summary · context
    Inpatients with mental disorders (N = 87) participating in a randomized controlled trial received OT (n = 44) or placebo (n = 43) intranasally twice a day, for four weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In inpatients with mental disorders, the covariance of patient and therapist ratings across sessions was significant with placebo but not with oxytocin.

    In plain wordsIn inpatients, patient and therapist ratings moved together across sessions with placebo but not with oxytocin.

    Peptide
    Oxytocin
    Outcome
    MixedMutual covariance of patient-therapist alliance ratings
    Study

    n = 87

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasal · four weeksAs given in this study (human).

    Source sentences

    Summary
    On the other hand, the mutual covariance of patient-therapist ratings across sessions was positive and significant for patients receiving placebo (b = 0.26, p = 0.01) but not for patients in the OT group (b = -0.06, p = .56).
    1 context sentence
    Summary · context
    Inpatients with mental disorders (N = 87) participating in a randomized controlled trial received OT (n = 44) or placebo (n = 43) intranasally twice a day, for four weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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