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Study · Animal study (in vivo) · 2023

10 results

In situ photo-crosslinkable hyaluronic acid-based hydrogel embedded with GHK peptide nanofibers for bioactive wound healing.

Lee S, Lee SM, Lee SH, Choi WK, Park SJ, Kim DY, Oh SW, Oh J, Cho JY, Lee J, Chien PN, Nam SY and 4 more

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Heo CY, Lee YS, Kwak EA, Chung WJ

Acta biomaterialia11 Oct 2023Cited by 18 (Europe PMC)

PMID37832839 (opens in a new tab)DOI10.1016/j.actbio.2023.10.011 (opens in a new tab)PepBankPUB-37832839
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In in vivo wound healing experiments, the Cu-GHK NF/HA-Ty hydrogel accelerated wound healing.

    In plain wordsIn animal tests, the hydrogel with copper GHK nanofibers sped up wound healing.

    Peptide
    GHK-Cu
    Outcome
    IncreaseWound healing rate in vivo
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, in vivo wound healing experiments revealed that the Cu-GHK NF/HA-Ty hydrogel accelerated wound healing
    1 context sentence
    Summary · context
    In vivo experiments further validate its efficacy, demonstrating significant wound closure, collagen remodeling, and increased fibroblast density.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In in vivo wound healing experiments, the Cu-GHK NF/HA-Ty hydrogel produced densely packed remodeled collagen in the dermis.

    In plain wordsIn animal tests, the hydrogel with copper GHK nanofibers led to denser, remodeled collagen in the skin.

    Peptide
    GHK-Cu
    Outcome
    IncreaseDermal collagen remodeling
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, in vivo wound healing experiments revealed that the Cu-GHK NF/HA-Ty hydrogel accelerated wound healing through densely packed remodeled collagen in the dermis
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In in vivo wound healing experiments, the Cu-GHK NF/HA-Ty hydrogel promoted the growth of denser fibroblasts.

    In plain wordsIn animal tests, the hydrogel with copper GHK nanofibers led to more fibroblasts in the wound.

    Peptide
    GHK-Cu
    Outcome
    IncreaseFibroblast density
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    promoting the growth of denser fibroblasts.
    1 context sentence
    Summary · context
    In vivo experiments further validate its efficacy, demonstrating significant wound closure, collagen remodeling, and increased fibroblast density.
  4. 04LabIn vitro (cells)Efficacy outcome

    The GHK nanofiber hydrogels promoted the proliferation of dermal fibroblasts.

    In plain wordsIn cells, a hydrogel containing GHK nanofibers helped skin fibroblast cells multiply.

    Peptide
    GHK-Cu
    Outcome
    IncreaseDermal fibroblast proliferation
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The hydrogels provided a microenvironment that promoted the proliferation of dermal fibroblasts
    1 context sentence
    Summary · context
    A versatile hydrogel was developed for enhancing bioactive wound healing by introducing the amphiphilic GHK peptide (GHK-C16) into a photo-crosslinkable tyramine-modified hyaluronic acid (HA-Ty).
  5. 05LabOther designEfficacy outcome

    The GHK nanofiber hydrogels promoted the activation of cytokines during wound healing.

    In plain wordsIn lab tests, a hydrogel containing GHK nanofibers raised cytokine activity during wound healing.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCytokine activation
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and the activation of cytokines
    1 context sentence
    Summary · context
    A versatile hydrogel was developed for enhancing bioactive wound healing by introducing the amphiphilic GHK peptide (GHK-C16) into a photo-crosslinkable tyramine-modified hyaluronic acid (HA-Ty).
  6. 06LabOther designEfficacy outcome

    The GHK nanofiber hydrogels led to reduced inflammation during wound healing.

    In plain wordsIn lab tests, a hydrogel containing GHK nanofibers led to less inflammation during wound healing.

    Peptide
    GHK-Cu
    Outcome
    DecreaseInflammation during wound healing
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    leading to reduced inflammation and increased collagen expression during wound healing
    1 context sentence
    Summary · context
    A versatile hydrogel was developed for enhancing bioactive wound healing by introducing the amphiphilic GHK peptide (GHK-C16) into a photo-crosslinkable tyramine-modified hyaluronic acid (HA-Ty).
  7. 07LabOther designEfficacy outcome

    The GHK nanofiber hydrogels led to increased collagen expression during wound healing.

    In plain wordsIn lab tests, a hydrogel containing GHK nanofibers led to more collagen expression during wound healing.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCollagen expression during wound healing
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased collagen expression during wound healing.
    1 context sentence
    Summary · context
    A versatile hydrogel was developed for enhancing bioactive wound healing by introducing the amphiphilic GHK peptide (GHK-C16) into a photo-crosslinkable tyramine-modified hyaluronic acid (HA-Ty).
  8. 08LabOther designEfficacy outcome

    Complexation of Cu2+ into GHK nanofibers gave superior wound healing capabilities compared with non-lipidated GHK peptide at a comparable level of EGF.

    In plain wordsIn lab tests, GHK nanofibers with copper healed wounds better than plain GHK peptide, at a similar growth factor level.

    Peptide
    GHK-Cu
    Outcome
    IncreaseWound healing capability of Cu-GHK nanofibers
    Study

    n: not reported in source

    Comparator
    Non-lipidated GHK peptide
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The complexation of Cu2+ into GHK nanofibers resulted in superior wound healing capabilities compared with non-lipidated GHK peptide with a comparable level of growth factor (EGF).
  9. 09LabOther designEfficacy outcome

    Nanostructured Cu-GHK improved angiogenesis through vascular endothelial growth factor (VEGF) activation.

    In plain wordsIn lab tests, GHK nanofibers with copper improved new blood vessel formation by activating VEGF.

    Peptide
    GHK-Cu
    Outcome
    IncreaseAngiogenesis via VEGF activation
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, nanostructured Cu-GHK improved angiogenesis through vascular endothelial growth factor (VEGF) activation, which exerted a synergistic therapeutic effect.

Studies that did not test the peptide alone1

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 10LabNot a test of GHK-Cu aloneOther designOther

    HA-Ty hydrogels incorporating GHK nanofibers had improved mechanical properties.

    In plain wordsIn lab tests, the hydrogel containing GHK nanofibers had better mechanical properties.

    Peptide
    GHK-Cu
    Outcome
    IncreaseMechanical properties of GHK nanofiber hydrogel
    Study

    n: not reported in source

    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    HA-Ty hydrogels incorporating GHK NF also possessed improved mechanical properties

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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