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Study · Randomized controlled trial · 2023

7 results

Bowel preparation efficacy and safety of compound polyethylene glycol electrolyte powder combined with linaclotide for colonoscopy: A randomized controlled trial.

Yang J, Wei Q, Xiang Z, Wu D, Lin Z

JGH open : an open access journal of gastroenterology and hepatology31 Aug 2023Cited by 12 (Europe PMC)

PMID37744708 (opens in a new tab)PMCIDPMC10517441 (opens in a new tab)DOI10.1002/jgh3.12961 (opens in a new tab)PepBankPUB-37744708
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanRandomized controlled trialSafety outcome

    In colonoscopy patients, adverse reaction incidence with 2LPEG plus linaclotide was compatible with 2LPEG alone.

    In plain wordsIn colonoscopy patients, adverse reaction rates were similar with 2LPEG plus linaclotide and 2LPEG alone.

    Peptide
    Linaclotide
    Outcome
    Direction not reportedAdverse reactions
    Study

    n: not reported in source

    Comparator
    2LPEG alone
    Analysis
    Secondary
    Outcome group
    Adverse events · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Patient's sleeping quality and the incidence of adverse reactions of 2LPEG + L group were compatible with 2LPEG group, but it was significantly lower than that in 4LPEG group.
    1 context sentence
    Summary · context
    A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, polyp detection did not differ significantly between 2LPEG plus linaclotide and 2LPEG alone.

    In plain wordsIn colonoscopy patients, polyp detection did not differ significantly between 2LPEG plus linaclotide and 2LPEG alone.

    Peptide
    Linaclotide
    Outcome
    No significant changeColon polyp detection
    Study

    n: not reported in source

    Comparator
    2LPEG alone
    Analysis
    Secondary
    Outcome group
    Bowel Preparation · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There was no statistically significant difference in the detection rate of colon polyps between each group.
    1 context sentence
    Summary · context
    A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, adding linaclotide to 2LPEG increased total colon BBPS score versus 2LPEG alone (P < 0.001).

    In plain wordsIn colonoscopy patients, adding linaclotide to 2LPEG improved total colon cleansing compared with 2LPEG alone.

    Peptide
    Linaclotide
    Outcome
    IncreaseTotal colon BBPS score
    Study

    n: not reported in source

    Comparator
    2LPEG alone
    Outcome group
    Bowel Preparation · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mean BBPS score of the total colon, left hemi-colon, right hemi-colon, and transverse in the 2LPEG + L group was higher than that in the 2LPEG group (P < 0.001).
    1 context sentence
    Summary · context
    A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, adding linaclotide to 2LPEG increased left hemi-colon BBPS score versus 2LPEG alone (P < 0.001).

    In plain wordsIn colonoscopy patients, adding linaclotide to 2LPEG improved left colon cleansing compared with 2LPEG alone.

    Peptide
    Linaclotide
    Outcome
    IncreaseLeft hemi-colon BBPS score
    Study

    n: not reported in source

    Comparator
    2LPEG alone
    Outcome group
    Bowel Preparation · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mean BBPS score of the total colon, left hemi-colon, right hemi-colon, and transverse in the 2LPEG + L group was higher than that in the 2LPEG group (P < 0.001).
    1 context sentence
    Summary · context
    A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide).
  5. 05HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, adding linaclotide to 2LPEG increased right hemi-colon BBPS score versus 2LPEG alone (P < 0.001).

    In plain wordsIn colonoscopy patients, adding linaclotide to 2LPEG improved right colon cleansing compared with 2LPEG alone.

    Peptide
    Linaclotide
    Outcome
    IncreaseRight hemi-colon BBPS score
    Study

    n: not reported in source

    Comparator
    2LPEG alone
    Outcome group
    Bowel Preparation · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mean BBPS score of the total colon, left hemi-colon, right hemi-colon, and transverse in the 2LPEG + L group was higher than that in the 2LPEG group (P < 0.001).
    1 context sentence
    Summary · context
    A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide).
  6. 06HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, adding linaclotide to 2LPEG increased transverse colon BBPS score versus 2LPEG alone (P < 0.001).

    In plain wordsIn colonoscopy patients, adding linaclotide to 2LPEG improved transverse colon cleansing compared with 2LPEG alone.

    Peptide
    Linaclotide
    Outcome
    IncreaseTransverse colon BBPS score
    Study

    n: not reported in source

    Comparator
    2LPEG alone
    Outcome group
    Bowel Preparation · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mean BBPS score of the total colon, left hemi-colon, right hemi-colon, and transverse in the 2LPEG + L group was higher than that in the 2LPEG group (P < 0.001).
    1 context sentence
    Summary · context
    A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide).
  7. 07HumanRandomized controlled trialEfficacy outcome

    In colonoscopy patients, sleeping quality with 2LPEG plus linaclotide was compatible with 2LPEG alone.

    In plain wordsIn colonoscopy patients, sleep quality was similar with 2LPEG plus linaclotide and 2LPEG alone.

    Peptide
    Linaclotide
    Outcome
    Direction not reportedSleeping quality
    Study

    n: not reported in source

    Comparator
    2LPEG alone
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Patient's sleeping quality and the incidence of adverse reactions of 2LPEG + L group were compatible with 2LPEG group, but it was significantly lower than that in 4LPEG group.
    1 context sentence
    Summary · context
    A total of 266 patients who underwent colonoscopy in Shangrao People's Hospital from June 2021 to June 2022 were randomized to 1 of 3 split PEG regimens: 4LPEG, 2LPEG, and 2LPEG + L (linaclotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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