Local injection of abaloparatide promotes mandibular condyle lengthening in adolescent rats via enhancing chondrogenesis and ossification.

Xu L, Li Y, Mei L, Qi H, Fang J, Li Y

Journal of oral rehabilitation19 Sept 2023Cited by 3 (Europe PMC)

PMID37727017DOI10.1111/joor.13597PepBankPUB-37727017

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In adolescent rats, abaloparatide increased condylar process length versus saline by 1.34 ± 0.59 mm at 6 weeks.
In plain wordsIn rats, abaloparatide increased jaw condyle length more than saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseMandibular condylar process length
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · 6 weeksAs given in this study (rat).
Measurements
Length increase
1.34 mm
6 weeks
Source sentences
Summary
In vivo, compared with the control, the ABL group significantly increased the mandibular condylar process length (by 1.34 ± 0.59 mm at 6 weeks), the thickness of the cartilage layer, and enhanced the matrix synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701701
02AnimalAnimal study (in vivo)Efficacy outcome
In adolescent rats, abaloparatide increased cartilage layer thickness versus saline.
In plain wordsIn rats, abaloparatide increased cartilage thickness more than saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseCartilage layer thickness
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
In vivo, compared with the control, the ABL group significantly increased the mandibular condylar process length (by 1.34 ± 0.59 mm at 6 weeks), the thickness of the cartilage layer, and enhanced the matrix synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701702
03AnimalAnimal study (in vivo)Efficacy outcome
In adolescent rats, abaloparatide enhanced cartilage matrix synthesis versus saline.
In plain wordsIn rats, abaloparatide increased cartilage matrix production more than saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseCartilage matrix synthesis
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
In vivo, compared with the control, the ABL group significantly increased the mandibular condylar process length (by 1.34 ± 0.59 mm at 6 weeks), the thickness of the cartilage layer, and enhanced the matrix synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701703
04AnimalAnimal study (in vivo)Mechanism
In adolescent rats, abaloparatide increased cartilage SOX 9 expression versus saline.
In plain wordsIn rats, abaloparatide increased cartilage SOX 9 expression more than saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseCartilage SOX 9 expression
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
The ABL group had significant up-regulation of SOX 9, COL II, PTHrP and PTH1R, down-regulation of COL X in the cartilage, up-regulation of RUNX 2, and unchanged osteoclastogenesis in the subchondral bone.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701704
05AnimalAnimal study (in vivo)Mechanism
In adolescent rats, abaloparatide increased cartilage COL II expression versus saline.
In plain wordsIn rats, abaloparatide increased cartilage COL II expression more than saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseCartilage COL II expression
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
The ABL group had significant up-regulation of SOX 9, COL II, PTHrP and PTH1R, down-regulation of COL X in the cartilage, up-regulation of RUNX 2, and unchanged osteoclastogenesis in the subchondral bone.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701705
06AnimalAnimal study (in vivo)Mechanism
In adolescent rats, abaloparatide increased cartilage PTHrP expression versus saline.
In plain wordsIn rats, abaloparatide increased cartilage PTHrP expression more than saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseCartilage PTHrP expression
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
The ABL group had significant up-regulation of SOX 9, COL II, PTHrP and PTH1R, down-regulation of COL X in the cartilage, up-regulation of RUNX 2, and unchanged osteoclastogenesis in the subchondral bone.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701706
07AnimalAnimal study (in vivo)Mechanism
In adolescent rats, abaloparatide increased cartilage PTH1R expression versus saline.
In plain wordsIn rats, abaloparatide increased cartilage PTH1R expression more than saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseCartilage PTH1R expression
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
The ABL group had significant up-regulation of SOX 9, COL II, PTHrP and PTH1R, down-regulation of COL X in the cartilage, up-regulation of RUNX 2, and unchanged osteoclastogenesis in the subchondral bone.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701707
08AnimalAnimal study (in vivo)Mechanism
In adolescent rats, abaloparatide decreased cartilage COL X expression versus saline.
In plain wordsIn rats, abaloparatide reduced cartilage COL X expression compared with saline.
Peptide
Abaloparatide (Tymlos)
Outcome
DecreaseCartilage COL X expression
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
The ABL group had significant up-regulation of SOX 9, COL II, PTHrP and PTH1R, down-regulation of COL X in the cartilage, up-regulation of RUNX 2, and unchanged osteoclastogenesis in the subchondral bone.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701708
09AnimalAnimal study (in vivo)Mechanism
In adolescent rats, abaloparatide increased RUNX 2 expression versus saline.
In plain wordsIn rats, abaloparatide increased RUNX 2 expression more than saline.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseRUNX 2 expression
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
The ABL group had significant up-regulation of SOX 9, COL II, PTHrP and PTH1R, down-regulation of COL X in the cartilage, up-regulation of RUNX 2, and unchanged osteoclastogenesis in the subchondral bone.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701709
10AnimalAnimal study (in vivo)Efficacy outcome
In adolescent rats, abaloparatide did not change subchondral osteoclastogenesis versus saline.
In plain wordsIn rats, abaloparatide did not change bone-resorbing cell formation compared with saline.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeSubchondral osteoclastogenesis
Study
ratn: not reported in source
Adolescent male Sprague-Dawley rats
Comparator
Normal saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intra-articular injection into the temporomandibular joint · up to 6 weeksAs given in this study (rat).
Source sentences
Summary
The ABL group had significant up-regulation of SOX 9, COL II, PTHrP and PTH1R, down-regulation of COL X in the cartilage, up-regulation of RUNX 2, and unchanged osteoclastogenesis in the subchondral bone.
1 context sentence(design, population, supporting numbers)
Summary · context
Thirty adolescent male Sprague-Dawley rats were randomly divided into two groups, which received the injection of ABL or normal saline (the control) every 3 days in the temporomandibular joint (TMJ) cavity.
Report a problemFND-3772701710
11LabIn vitro (cells)Efficacy outcome
In cultured mandibular condylar chondrocytes, abaloparatide promoted proliferation versus PBS.
In plain wordsIn cells, abaloparatide increased jaw cartilage cell growth compared with PBS.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseCondylar chondrocyte proliferation
Study
n: not reported in source
Mandibular condylar chondrocytes
Comparator
PBS
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In vitro, the intra-TMJ injection of ABL promoted the MCC proliferation, with up-regulated expression of chondrogenic genes, and enhanced osteogenic differentiation of the pre-osteoblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
Mandibular condylar chondrocytes (MCC) and pre-osteoblasts were treated with ABL or PBS, followed by the CCK-8 detection, IC50, real-time PCR assay, Western Blot and immunofluorescence staining.
Report a problemFND-3772701711
12LabIn vitro (cells)Mechanism
In cultured mandibular condylar chondrocytes, abaloparatide increased chondrogenic gene expression versus PBS.
In plain wordsIn cells, abaloparatide increased cartilage-forming gene expression compared with PBS.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseChondrogenic gene expression
Study
n: not reported in source
Mandibular condylar chondrocytes
Comparator
PBS
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In vitro, the intra-TMJ injection of ABL promoted the MCC proliferation, with up-regulated expression of chondrogenic genes, and enhanced osteogenic differentiation of the pre-osteoblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
Mandibular condylar chondrocytes (MCC) and pre-osteoblasts were treated with ABL or PBS, followed by the CCK-8 detection, IC50, real-time PCR assay, Western Blot and immunofluorescence staining.
Report a problemFND-3772701712
13LabIn vitro (cells)Efficacy outcome
In cultured pre-osteoblasts, abaloparatide enhanced osteogenic differentiation versus PBS.
In plain wordsIn cells, abaloparatide increased development into bone-forming cells compared with PBS.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreasePre-osteoblast osteogenic differentiation
Study
n: not reported in source
Pre-osteoblasts
Comparator
PBS
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
In vitro, the intra-TMJ injection of ABL promoted the MCC proliferation, with up-regulated expression of chondrogenic genes, and enhanced osteogenic differentiation of the pre-osteoblasts.
1 context sentence(design, population, supporting numbers)
Summary · context
Mandibular condylar chondrocytes (MCC) and pre-osteoblasts were treated with ABL or PBS, followed by the CCK-8 detection, IC50, real-time PCR assay, Western Blot and immunofluorescence staining.
Report a problemFND-3772701713

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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